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CROSCARMELLOSE SODIUM

CROSCARMELLOSE SODIUM Struktur
74811-65-7
CAS-Nr.
74811-65-7
Englisch Name:
CROSCARMELLOSE SODIUM
Synonyma:
Sodiumcroscarmellose;PRIMELLOSE(R);Unii-m28ol1hh48;Ac-Di-Sol SD711;Crosscarmelosesodium;Croscarmelose Sodium;CROSCARMELLOSE SODIUM;MODIFIED CELLULOSE GUM;Croscarmellose natrium;Ropinirole Impurity 11-d4
CBNumber:
CB9418013
Summenformel:
Null
Molgewicht:
0
MOL-Datei:
Mol file

CROSCARMELLOSE SODIUM Eigenschaften

Schmelzpunkt:
>205oC (dec.)
Dichte
Bulk density (g/cc) 0.48
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
L?slichkeit
Practically insoluble in acetone, in anhydrous ethanol and in toluene.
Aggregatzustand
Solid
Farbe
White to Off-White
Geruch (Odor)
at 100.00?%. odorless
EPA chemische Informationen
Croscarmellose sodium (74811-65-7)

Sicherheit

CROSCARMELLOSE SODIUM Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Croscarmellose sodium occurs as an odorless, white or grayishwhite powder.

Verwenden

Croscarmellose Sodiumis a super disintegrant used in pharmaceuticals in the synthesis of tablets for oral administration.

Vorbereitung Methode

Alkali cellulose is prepared by steeping cellulose, obtained from wood pulp or cotton fibers, in sodium hydroxide solution. The alkali cellulose is then reacted with sodium monochloroacetate to obtain carboxymethylcellulose sodium. After the substitution reaction is completed and all of the sodium hydroxide has been used, the excess sodium monochloroacetate slowly hydrolyzes to glycolic acid. The glycolic acid changes a few of the sodium carboxymethyl groups to the free acid and catalyzes the formation ofcrosslinkstoproducecroscarmellosesodium.Thecroscarmellose sodium is then extracted with aqueous alcohol and any remaining sodium chloride or sodium glycolate is removed. After purification, croscarmellose sodium of purity greater than 99.5% is obtained. The croscarmellose sodium may be milled to break the polymer fibers into shorter lengths and hence improve its flow properties.

Pharmazeutische Anwendungen

Croscarmellose sodium is used in oral pharmaceutical formulations as a disintegrant for capsules,tablets, and granules.
In tablet formulations, croscarmellose sodium may be used in bothdirect-compressionandwet-granulationprocesses.Whenused in wet granulations, the croscarmellose sodium should be added in both the wet and dry stages of the process (intra- and extragranularly) so that the wicking and swelling ability of the disintegrant is best utilized. Croscarmellose sodium at concentrations up to 5% w/w may be used as a tablet disintegrant, although normally 2% w/w is used in tablets prepared by direct compression and 3% w/w in tablets prepared by a wet-granulation process.

Sicherheit(Safety)

Croscarmellose sodium is mainly used as a disintegrant in oral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. However, oral consumption of large amounts of croscarmellose sodium may have a laxative effect, although the quantities used in solid dosage formulations are unlikely to cause such problems.
In the UK, croscarmellose sodium is accepted for use in dietary supplements.
The WHO has not specified an acceptable daily intake for the related substance carboxymethylcellulose sodium, used as a food additive, since the levels necessary to achieve a desired effect were not considered sufficient to be a hazard to health.

Lager

Croscarmellose sodium is a stable though hygroscopic material.
A model tablet formulation prepared by direct compression, withcroscarmellosesodiumasadisintegrant,showednosignificant differenceindrugdissolutionafterstorageat30°Cfor14months.
Croscarmellose sodium should be stored in a well-closed container in a cool, dry place.

Inkompatibilit?ten

The efficacy of disintegrants, such as croscarmellose sodium, may be slightly reduced in tablet formulations prepared by either the wet-granulation or direct-compression process that contain hygroscopic excipients such as sorbitol.
Croscarmellose sodium is not compatible with strong acids or with soluble salts of iron and some other metals such as aluminum, mercury, and zinc.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, granules, sublingual tablets, and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

CROSCARMELLOSE SODIUM Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


CROSCARMELLOSE SODIUM Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 208)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jiangxi Alpha Hi-tech Pharmaceutical Co., Ltd
510-85010237
overseamarketing@alphahi-tech.com CHINA 41 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5858 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18155 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 2990 58
airuikechemical co., ltd.
+undefined86-15315557071
sales02@sdzhonghuimaterial.com China 983 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21637 55

74811-65-7()Verwandte Suche:


  • CROSCARMELLOSE SODIUM
  • MODIFIED CELLULOSE GUM
  • PRIMELLOSE(R)
  • Crosscarmelosesodium
  • Croscarmellose natrium
  • Cross-linked carboxymethylcellulose sodium
  • Unii-m28ol1hh48
  • CroscarMellose sodiuM Ph. Eur.
  • Sodiumcroscarmellose
  • 1,4-Pentanediamine,N4-(6-methoxy-13-quinolinyl)-
  • Ropinirole Impurity 11-d4
  • Croscarmelose Sodium
  • Croscarmellose Sodium (20 mg)
  • Ac-Di-Sol SD711
  • 74811-65-7
  • 4811-65-7
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