Tolcapone
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- CAS-Nr.
- 134308-13-7
- Englisch Name:
- Tolcapone
- Synonyma:
- Tasmar;TOLCAPONE;TALCAPONE;ro40-7592;TOLOCAPONE;Tolcapone (200 mg);TolcaponeTolcapone;Tolcapone USP/EP/BP;Tolcapone (1670207);(3,4-Dihydroxy-5-nitrophenyl)
- CBNumber:
- CB9302569
- Summenformel:
- C14H11NO5
- Molgewicht:
- 273.24
- MOL-Datei:
- 134308-13-7.mol
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Tolcapone Eigenschaften
- Schmelzpunkt:
- 126-1280C
- Siedepunkt:
- 485.6±45.0 °C(Predicted)
- Dichte
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥15mg/mL
- pka
- 4.78±0.38(Predicted)
- Aggregatzustand
- powder
- Farbe
- yellow
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- CAS Datenbank
- 134308-13-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
N |
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| R-S?tze: |
50 |
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| S-S?tze: |
61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| RTECS-Nr. |
PC4952500 |
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| HS Code |
2914710000 |
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| Toxizit?t |
mouse,LD50,oral,1600mg/kg (1600mg/kg),BEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 24(Suppl, |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Tolcapone Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Yellow Solid
Verwenden
Tolcapone may be used in COMT-mediated cell signaling studies.
Tolcapone has been used in methyltransferase assay in human embryonic kidney 293 cells.
synthetische
preparation by demethylation of 4-hydroxy-3-methoxy-4′-methyl-5-nitrobenzophenone with hydrobromic acid in refluxing aque-ous acetic acid.
Allgemeine Beschreibung
Tolcapone, 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone (Tasmar), is a yellow, odorless, nonhygroscopic,crystalline compound (pK
a＝4.78). Tolcapone israpidly absorbed after oral administration. Tolcapone ishighly bound to plasma albumin (＞98%), and its distributionis therefore restricted. Tolcapone has low first-pass metabolism.It is almost completely metabolized in the liver before excretion, and 60% is excreted by the kidney. The majormetabolite of tolcapone is an inactive glucuronide conjugate.COMT inhibitors increase chronotropic and arrhythmogeniceffects of epinephrine.Tolcapone is indicated as an adjunctto levodopa/carbidopa for the management of signs andsymptoms of PD.
Tolcapone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tolcapone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 226)Lieferanten
134308-13-7()Verwandte Suche:
- TOLOCAPONE
- 3,4-DIHYDROXYL-5-NITROBENZENYL,4-METHYLBENZENYL KETONE, TALCAPONE
- Tolcapone (200 mg)
- Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-Methylphenyl)-
- (3,4-Dihydroxy-5-nitrophenyl)(p-tolyl)methanone
- 3,4-DIHYDROXYL-5-NITROBENZYL,4'-METHYLBENZENYL KETONE
- (3,4-Dihydroxy-5-nitrophenyl)
- TALCAPONE
- TOLCAPONE
- (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-methanon
- (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
- 3,4-dihydroxy-4’-methyl-5-nitrobenzophenone
- ro40-7592
- TolcaponeTolcapone
- Tasmar
- Tolcapone USP/EP/BP
- TolcaponeQ: What is
Tolcapone Q: What is the CAS Number of
Tolcapone Q: What is the storage condition of
Tolcapone Q: What are the applications of
Tolcapone
- Tolcapone (1670207)
- 3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
- 134308-13-7
- Inhibitors
- API
- Inhibitor
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Aromatics
- 134308-13-7
