3-Chlorpropionylchlorid
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3-Chlorpropionylchlorid Eigenschaften
- Schmelzpunkt:
- -32 °C
- Siedepunkt:
- 143-145 °C(lit.)
- Dichte
- 1.33 g/mL at 25 °C(lit.)
- Dampfdruck
- 10.0 hPa
- Brechungsindex
- n
20/D 1.457(lit.)
- RTECS-Nr.
- UC3934000
- Flammpunkt:
- 146 °F
- storage temp.
- Flammables area
- L?slichkeit
- Chloroform, Ethyl Acetate
- Aggregatzustand
- liquid
- Farbe
- red-brown
- PH
- <7 (H2O)
- Explosionsgrenze
- 8.8-20.2%(V)
- Wasserl?slichkeit
- reacts
- Sensitive
- Moisture Sensitive
- BRN
- 635814
- Stabilit?t:
- Moisture Sensitive
- InChIKey
- INUNLMUAPJVRME-UHFFFAOYSA-N
- CAS Datenbank
- 625-36-5(CAS DataBase Reference)
- NIST chemische Informationen
- Propanoyl chloride, 3-chloro-(625-36-5)
- EPA chemische Informationen
- Propanoyl chloride, 3-chloro- (625-36-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | T+ | ||
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R-S?tze: | 14-22-26-34-35-10 | ||
S-S?tze: | 23-26-36/37/39-45-38-16-8 | ||
RIDADR | UN 3390 6.1/PG 1 | ||
WGK Germany | 1 | ||
F | 21 | ||
TSCA | Yes | ||
HazardClass | 6.1 | ||
PackingGroup | I | ||
HS Code | 29159080 |
Bildanzeige (GHS) | |||||||||||||||||||||||||||||
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Alarmwort | Achtung | ||||||||||||||||||||||||||||
Gefahrenhinweise |
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Sicherheit |
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3-Chlorpropionylchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R14:Reagiert heftig mit Wasser.R22:Gesundheitssch?dlich beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R34:Verursacht Ver?tzungen.
R35:Verursacht schwere Ver?tzungen.
R10:Entzündlich.
S-S?tze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S38:Bei unzureichender Belüftung Atemschutzger?t anlegen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S8:Beh?lter trocken halten.
Beschreibung
3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.Chemische Eigenschaften
Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.Verwenden
3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.synthetische
3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.Reaktionen
(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist.(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported.
(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.
3-Chlorpropionylchlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Dibenzoylperoxid
Propionylchlorid
3-Chlorpropionsure
2-Chlorpropionylchlorid
Tetrachlormethan
Sulfuryldichlorid
Thionyldichlorid
Downstream Produkte
Tetrahydro-4H-pyran-4-ol
3,6-Dihydro-4-methoxy-2H-pyran
Tetrahydro-4H-pyran-4-on
Moracizin
2-Chlorethylisocyanat
CO-1686
4,5-Dihydro-1H-pyrazol
3-CHLORO-1-(2-METHYLPHENYL)-1-OXOPROPANE
2-Propens?ure-2-diethylamino)-ethylester
PYROQUILON
3-Chloro-1-(4-methoxyphenyl)propan-1-one
1 5-DICHLORO-3-PENTANONE
3-chloro-N-(2,4-dimethylphenyl)propanamide
3-CHLORO-N-CYCLOHEXYLPROPANAMIDE
3-Chlorpropionylchlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 442)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
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Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 |
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info@dakenam.com | China | 18751 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1803 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
625-36-5(3-Chlorpropionylchlorid)Verwandte Suche:
Propionylchlorid
2-Chlorpropionylchlorid
2,3-Dichlorpropionylchlorid
3-Chlor-2,2-dimethylpropanoylchlorid
3-Chlorpropionylchlorid
Malonyldichlorid
- 3-CHLOROPROPIONYL CHLORIDE FOR SYNTHESIS
- 3 - chlorine propionyl chloride
- -Chloropropanoylchloride
- Propionyl chloride, 3-chloro-
- BETA-CHLOROPROPIONYL CHLORIDE
- 3-Chloropropionyl chlorode
- 3-CHLOROPROPIONYL CHLORIDE, TECH.
- 3-ChloropropionylChloride,~97%
- 3-CHLOROPROPIONYL CHLORIDE
- 3-CHLOROPROPIONIC ACID CHLORIDE
- Propanoyl chloride, 3-chloro-
- 3-CHLOROPROPIONYL CHLORIDE:SS-CHLOROPROPIONLY CHLORIDE
- 3-Chloropropionoic acid chloranhydride
- b-Chloropropanoyl chloride
- 3-Chloropropinyl chloride
- 3-Chlorpropionylchlorid
- 3-CHLOROPROPIONYL CHLORIDE 99%
- 3-chloro-propanoylchlorid
- beta-Chloropropanoyl chloride
- beta-Chloropropionic acid chloride
- beta-Chloropropionoyl chloride
- 3-Chloropropionyl ch
- 3-Chloropropionyl chloride, 98% 100ML
- 3-Chloropropionyl chloride,98%
- β-Chloropropionly chloride
- oropropionyL
- 3-Chloropropionyl Chloride >
- 3-Chloropropionyl chloride 625-36-5
- Chloropropionyl chloride
- 3-Chloropropanoyl chloride
- 3-Chloropropionyl chloride625-36-5 CAS NO.625-36-5 CAS NO.625-36-5
- 6. 3-Chloropropionyl Chloride
- 3'ChloropropionylChloride
- 625-36-5
- C3H4OCl2
- C3H4CI2O
- ClCH2CH2COCl
- ACID CHLORIDE
- Building Blocks
- Carbonyl Compounds
- Acid Halides
- Organic Building Blocks
- Halogen compounds
- API Intermediate
- Pyridines ,Halogenated Heterocycles
- Acid Halides
- Carbonyl Compounds
- Organic Building Blocks