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Moracizin

Moricizine Struktur
31883-05-3
CAS-Nr.
31883-05-3
Bezeichnung:
Moracizin
Englisch Name:
Moricizine
Synonyma:
Moricizin;Moricizine;TIMTEC-BB SBB005991;Ethmozin:Moricizine;Ethyl (10-(3-Morpholinopropanoyl)-10H-phenothiazin-2-yl)carbaMate;ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate;10-(3-Morpholinopropionyl)phenothiazine-2-carbamic acid ethyl ester;N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamic acid ethyl ester;N-[10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl]carbamic acid ethyl ester;10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl carbaminoic acid, ethyl ester
CBNumber:
CB4493310
Summenformel:
C22H25N3O4S
Molgewicht:
427.52
MOL-Datei:
31883-05-3.mol

Moracizin Eigenschaften

Schmelzpunkt:
156-157°
Siedepunkt:
625.0±55.0 °C(Predicted)
Dichte
1.315±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
Chloroform (Slightly), Methanol (Very Slightly)
pka
6.4(at 25℃)
Aggregatzustand
Solid
Farbe
Pale Orange to Light Orange

Sicherheit

Moracizin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Moricizine, is Phenothiazine (P318040) derivative, which It was used as an Antiarrhythmic agent. It is also shown that moracizine is effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.

Definition

ChEBI: A phenothiazine substituted on the nitrogen by a 3-(morpholin-4-yl)propanoyl group, and at position 2 by an (ethoxycarbonyl)amino group.

Allgemeine Beschreibung

Moricizine, ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate (Ethmozine), is aphenothiazine derivative used for the treatment of malignantventricular arrhythmias. It is categorized as a class ICantiarrhythmic agent, blocking the Na+ channel with 1:1stochiometry. The drug has higher affinity for the inactivatedstate than the activated or resting states. It appearsto bind to a site on the external side of the Na channelmembrane. It has been used to suppress life-threateningventricular arrhythmias.

Clinical Use

Moricizine (Ethmozine) is an antiarrhythmic used to treat documented life-threatening arrhythmias.
Moricizine is indicated for the treatment of documented ventricular arrhythmias, particularly sustained ventricular tachycardia. Moricizine was evaluated in the CAST II clinical trial for the prevention of postinfarction ventricular premature complexes. It was ineffective and found to be proarrhythmic. Patients in the moricizine arm of the trial exhibited a greater incidence of sudden cardiac death than did controls.

Nebenwirkungen

The principal adverse gastrointestinal effect of moricizine is nausea (7%). Abdominal discomfort has also been reported. Dizziness (11%) is the most frequently reported CNS-related adverse effect. Such reactions increase in frequency with prolonged drug administration. As with other antiarrhythmic drugs, moricizine has proarrhythmic activity, which may manifest as new ventricular ectopic beats or a worsening of preexisting ventricular arrhythmias. These effects are most common in patients with depressed left ventricular function and a history of congestive heart failure. Cardiovascular effects requiring drug withdrawal include conduction defects, sinus pauses, junctional rhythm, and A-V block.

Arzneimittelwechselwirkung

Clinically significant interactions with moricizine do not appear to exist.

Vorsichtsma?nahmen

Patients with preexisting second- or third-degree A-V block, cardiogenic shock, or drug hypersensitivity should not be treated with moricizine.

Moracizin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Moracizin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 55)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20283 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19885 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Dandong Yichuang Pharmaceutical Co., Ltd 0415-3124267
China 35 60
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 94657 76

31883-05-3(Moracizin)Verwandte Suche:


  • TIMTEC-BB SBB005991
  • CARBAMIC ACID, [10-[3-(4-MORPHOLINYL)-1-OXOPROPYL]-10H-PHENOTHIAZIN-2-YL]-, ETHYL ESTER
  • Moricizine
  • Moricizin
  • 10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl carbaminoic acid, ethyl ester
  • 10-(3-Morpholinopropionyl)phenothiazine-2-carbamic acid ethyl ester
  • Ethmozin:Moricizine
  • N-[10-(3-Morpholinopropionyl)-10H-phenothiazin-2-yl]carbamic acid ethyl ester
  • ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate
  • N-[10-(3-morpholinopropanoyl)phenothiazin-2-yl]carbamic acid ethyl ester
  • Ethyl (10-(3-Morpholinopropanoyl)-10H-phenothiazin-2-yl)carbaMate
  • Carbamic acid, N-[10-[3-(4-morpholinyl)-1-oxopropyl]-10H-phenothiazin-2-yl]-, ethyl ester
  • 31883-05-3
  • C22H25N3O4S
  • API
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