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Phenoxybenzaminhydrochlorid

Phenoxybenzamine hydrochloride  Struktur
63-92-3
CAS-Nr.
63-92-3
Bezeichnung:
Phenoxybenzaminhydrochlorid
Englisch Name:
Phenoxybenzamine hydrochloride
Synonyma:
PHENOXYBENZAMINE;dibenzyline;PHENOXYBENZAMINE HCL;688A;Bensylyt;benzylyt;SKF-688A;dibenylin;NSC 37448;dibenzyran
CBNumber:
CB8172020
Summenformel:
C18H22ClNO.ClH
Molgewicht:
340.29
MOL-Datei:
63-92-3.mol

Phenoxybenzaminhydrochlorid Eigenschaften

Schmelzpunkt:
137.5°C
storage temp. 
15-25°C
L?slichkeit
soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
Aggregatzustand
powder
pka
pKa 4.4 (Uncertain)
Farbe
white
Wasserl?slichkeit
<0.01 g/100 mL at 18.5 ºC
Merck 
14,7256
Stabilit?t:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS Datenbank
63-92-3(CAS DataBase Reference)
IARC
2B (Vol. 24, Sup 7) 1987
EPA chemische Informationen
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride (63-92-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-40
S-S?tze: 22-36/37/39-45
WGK Germany  3
RTECS-Nr. DP3750000
HS Code  2922299000
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Phenoxybenzaminhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Phenoxybenzamine hydrochloride (dibenzyline) is an orally effective, long-acting non-selective (alpha1 and alpha2) alpha-adrenoceptor blocking agent. It is used for the control of episodes of hypertension associated withpheochromocytoma. It literally produces a "chemical sympathectomy". It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. The initialdose is 10 mg/day, increased by 10 mg every 4 days till the desired response is attained.The usual dosage range is 20-60mg/day.

Chemische Eigenschaften

white crystalline solid or powder. Odorless. soluble in ethanol, chloroform, propylene glycol, slightly soluble in benzene, slightly soluble in cold water. The melting point of its free base is 38-40 ° C, and it is soluble in benzene.

Verwenden

Phenoxybenzamine (5.0 to 60.0 mg/day) is used in order to control episodes of hypertension and sweating, it has a relatively slow onset and prolonged effect when compared to alternative α-blockers. If tachycardia is excessive, it may also be necessary to use a betablocker concomitantly. In addition, phenoxybenzamine has been tested for its efficacy in micturition disorders resulting from neurogenic bladder, functional outlet obstruction, and partial prostatic obstruction.

Allgemeine Beschreibung

Phenoxybenzamine hydrochloride is a white crystalline powder. Melting point 137.5-140°C. Used as an antihypertensive drug.

Air & Water Reaktionen

Light sensitive and may be sensitive to exposure to air . Insoluble in water.

Mechanism of action

Phenoxybenzamine hydrochloride is a noncompetitive alpha-adrenergicreceptor blocker, and its action cannot be nullified by increasing the amount of agonist, or agonists. It causes epinephrine reversal in that the administration of epinephrine after pretreatment with phenoxybenzamine elicits vasodilation, and, conversely, phenoxybenzamine reverses epinephrine-mediated vasoconstriction to vasodilation. It may inhibit neuronal and extraneuronal uptake mechanisms of norepinephrine. At higher concentrations, it inhibits responses to 5-HT, histamine and acetylcholine.

Clinical Use

Oral phenoxybenzamine is used for the preoperativemanagement of patients with pheochromocytoma and in thechronic management of patients whose tumors are notamenable to surgery. Only about 20% to 30% of an oraldose is absorbed.

Nebenwirkungen

The adverse effects of phenoxybenzamine include nasal congestion, miosis, postural hypotension, tachycardia, and inhibition of ejaculation.

Sicherheitsprofil

Confumed carcinogen with experimental carcinogenic and teratogenic data. Poison by intraperitoneal,intravenous, and subcutaneous routes. Human systemic effects by ingestion: changes in tubules, including acute renal failure, acute tubular necrosis. Moderately toxic by ingestion. Other experimental reproductive effects. Mutation data reported. A long-acting adrenergic blocker. When heated to decomposition it emits very toxic fumes of NOx and Cl-.

Carcinogenicity

Phenoxybenzamine hydrochloride is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Dosage

Initially, 10 mg of Dibenzyline (phenoxybenzamine hydrochloride) twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.

Phenoxybenzaminhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Phenoxybenzaminhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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63-92-3(Phenoxybenzaminhydrochlorid)Verwandte Suche:


  • benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride
  • dibenzyran
  • n-phenoxyisopropyl-n-benzyl-beta-chloroethylaminehydrochloride
  • phenoxybenzamidehydrochloride
  • BENZENE METHANAMINE HYDROCHLORIDE
  • DIBENZYLINE HYDROCHLORIDE
  • N-PHENOXYISOPROPYL-N-BENZYL-2-CHLOROETHYLAMINE HYDROCHLORIDE
  • PHENOXYBENZAMINE HYDROCHLORIDE
  • n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride
  • N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)BENZYLAMINE HYDROCHLORIDE
  • N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)- benzenemethanamine, hydrochloride (1:1)
  • C18H23ClNOphenoxybenzamine hydrochloride
  • PHENOXYBENZAMINE HCL;DIBENZYLINE HYDROCHLORIDE
  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
  • PHENOXYBENZAMINEHYDROCHLORIDE,USP
  • Bensylyt
  • BENZYLAMINE,N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)-HYDROCHLORIDE
  • fenossibenzamina
  • fenoxybenzamin
  • n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzenemethanaminhydrochlo
  • n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzylaminhydrochloride
  • n-2-phenoxyisopropyl-n-benzyl-chloroethylaminehydrochloride
  • n-benzyl-n-phenoxyisopropyl-beta-chlorethylaminehydrochloride
  • nci-c01661
  • 2-(n-benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
  • PHENOXYBENZAMINE HYDROCHLORIDE >97% SELE CTIVE A-ADRENERGI
  • PHENYOXYBENZAMINE HYDROCHLORIDE
  • 688A
  • benzylyt
  • dibenylin
  • Phenoxybenzamide, HCl
  • N-2-Phenoxyisopropyl-N-benzyl-b-chloroethylamine hydrochloride
  • Dibenyline hydrochloride
  • SKF-688A
  • N-Benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-aMine hydrochloride
  • Dibenzyline Chloride
  • NSC 37448
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine Hydrochloride Dibenzyline Hydrochloride N-Phenoxyisopropyl-N-benzyl-2-chloroethylamine Hydrochloride
  • Phenoxybenzamine Hydrochloride (250 mg)
  • bensylytnen
  • Phenoxybenzamide
  • Phenoxybenzamine Hydrochloride >
  • Phenoxybenzamine hydrochloride USP/EP/BP
  • Phenoxybenzamine HydrochlorideQ: What is Phenoxybenzamine Hydrochloride Q: What is the CAS Number of Phenoxybenzamine Hydrochloride Q: What is the storage condition of Phenoxybenzamine Hydrochloride Q: What are the applications of Phenoxybenzamine Hydrochloride
  • Phenoxybenzamine Hydrochloride (1526007)
  • PHENOXYBENZAMINE
  • PHENOXYBENZAMINE HCL
  • dibenzyline
  • Phenoxybenzamie Hydrochloride (Dibenzyline)
  • Phenoxybenzamine Hydrochloride, ≥ 95.0%
  • 63-92-3
  • C18H23ClNOCl
  • C18H23Cl2NO
  • C18H22ClNOHCl
  • C18H22ClNOClH
  • C18H23ClNO
  • DIBENZYLINE
  • Amines
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