Methylhydrazin Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE HYGROSKOPISCHE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
PHYSIKALISCHE GEFAHREN
Die D?mpfe mischen sich leicht mit Luft. Bildung explosionsf?higer Gemische.
CHEMISCHE GEFAHREN
Kann beim Erhitzen oder beim Kontakt mit Metalloxiden explodieren. Kann sich beim Kontakt mit Luft und por?sen Materialien wie Erde, Asbest, Holz oder Stoff spontan entzünden. Zersetzung beim Verbrennen unter Bildung giftiger und ?tzender Gase mit Stickstoffoxiden. Starkes Reduktionsmittel. Reagiert sehr heftig mit Oxidationsmitteln unter Feuergefahr. Mittelstarke Base. Reagiert sehr heftig mit starken S?uren.
ARBEITSPLATZGRENZWERTE
TLV: 0.01 ppm (als TWA); Hautresorption; Krebskategorie A3 (best?tigte krebserzeugende Wirkung beim Tier mit unbekannter Bedeutung für den Menschen); (ACGIH 2005).
MAK: IIb (nicht festgelegt, aber Informationen vorhanden); Hautresorption; Sensibilisierung der Haut; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation der D?mpfe, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann sehr schnell eine gesundheitssch?dliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz ver?tzt die Augen, die Haut und die Atemwege. ?tzend beim Verschlucken. M?glich sind Auswirkungen auf Zentralnervensystem, Leber und Blut mit nachfolgenden Lebersch?den und Meth?moglobinbildung. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann zum Tod führen. Die Auswirkungen treten u.U. verz?gert ein. ?rztliche Beobachtung notwendig.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
M?glich sind Auswirkungen auf Leber und Blut. Führt zu Lebersch?den und Meth?moglobinbildung. M?glicherweise krebserzeugend für den Menschen.
LECKAGE
Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Pers?nliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabh?ngigem Atemschutzger?t. NICHT in die Umwelt gelangen lassen.
R-S?tze Betriebsanweisung:
R11:Leichtentzündlich.
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R34:Verursacht Ver?tzungen.
R40:Verdacht auf krebserzeugende Wirkung.
R51/53:Giftig für Wasserorganismen, kann in Gew?ssern l?ngerfristig sch?dliche Wirkungen haben.
R45:Kann Krebs erzeugen.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Beh?lter sind als gef?hrlicher Abfall zu entsorgen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Methyl hydrazine, CH3NHNH2, is a colorless, hygroscopic liquid with an ammonia-like odor. It is soluble in water, with a specific gravity of 0.87, which is lighter than water. Methyl hydrazine is toxic by inhalation and ingestion, and is a suspected human carcinogen. The TLV ceiling is 0.2 ppm in air, and the IDLH is 50 ppm. The target organs are the central nervous system, respiratory system, liver, blood, eyes, and cardiovascular system. The four-digit UN identification number is 1244. The NFPA 704 designation is health 4, flammability 3, and reactivity 2. The primary uses are as a missile propellant and a solvent.
Chemische Eigenschaften
colourless liquid with an ammonia-like odour
Physikalische Eigenschaften
Fuming, clear, colorless liquid with an ammonia-like odor. Odor threshold concentrations ranged
from 1 to 3 ppm (quoted, Keith and Walters, 1992).
Verwenden
Methylhydrazine is used in missile propellants and as a
solvent and chemical intermediate.
Vorbereitung Methode
Methylhydrazine ignites spontaneously on contact with
strong oxidizing agents. It is prepared commercially from
the reaction of monochloroamine and monomethylamine.
Air & Water Reaktionen
Highly flammable. Often ignites spontaneously. Exposure to air on a large surface may result in spontaneous ignition [Def. Res. and Eng. 27. 1963]. Water soluble. Solutions are highly alkaline and generate heat when water is added.
Reaktivit?t anzeigen
Methylhydrazine is a powerful reducing agent. Ignites upon contact with oxidizing agents i.e. dinitrogen tetraoxide, hydrogen peroxide [Hawley]. Water used to extinguish a fire may cause pollution and should be diked for later disposal. Gives basic solutions with water that generate heat when water is added.
Hazard
Flammable, dangerous fire risk, vapors mayexplode, may self-ignite in air and on contact withoxidizing agents. Toxic by ingestion and inhalation.Eye and upper respiratory tract irritant, lung cancerand liver damage. Possible carcinogen.
Health Hazard
Methyl hydrazine vapors are extremely toxic and the liquid is corrosive to skin. Methyl hydrazine is the strongest convulsant and the most toxic of methyl-substituted hydrazine derivatives. It is more toxic than hydrazine. At high doses, it is a strong central nervous system poison that can lead to convulsions and death. Skin rash may be aggravated by skin exposure.
Brandgefahr
Extremely flammable; ignites spontaneously under almost all normal temperature conditions. Water used to extinguish a fire may cause pollution and should be diked for later disposal. Water may be ineffective in extinguishing fires due to the chemical's low flash point. Because of the wide flammability limits, low flash point, and reignition hazard, dry chemicals, carbon dioxide, water spray, and foam may not be as effective as water dilution of fire area. The vapor is heavier than air; thus Methylhydrazine may accumulate sufficiently to flash back. Methylhydrazine fires produce irritating nitrogen oxides. Ignites spontaneously in air when in contact with porous materials (e.g., earth, asbestos, wood, or cloth). Also ignites spontaneously on contact with strong oxidizing agents (e.g., fluorine, chlorine trifluoride, fuming nitric acid, and nitrogen tetroxide). Heat or flame should be avoided because chemical is extremely flammable and explosive.
Sicherheitsprofil
Suspected carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by inhalation, ingestion, skin
contact, intraperitoneal, subcutaneous, and
intravenous routes. Experimental
reproductive effects. Human mutation data
reported. Corrosive to skin, eyes and mucous membranes. May self-ignite in air.
Very dangerous fire hazard when exposed
to heat or flame. To fight fire, use alcohol
foam, CO2, dry chemical. Explosive in the
form of vapor when exposed to heat or
flame. A powerful reducing agent. It is
hypergolic with many oxidants (e.g.,
dinitrogen tetraoxide and hydrogen
peroxide). When heated to decomposition it
emits toxic fumes of NOx.
m?gliche Exposition
MMH has been used as the propellant
in liquid propellant rockets; it is also used as a solvent and
as an organic intermediate.
Carcinogenicity
The carcinogenicity of methylhydrazine
has been extensively investigated. In two studies,
no compound-related increase in tumor incidence was
observed in mice treated orally with methylhydrazine
. In other studies, methylhydrazine produced
lung tumors in mice and malignant histiocytoma of the liver
and cecal tumors in hamsters when administered in drinking
water at concentrations of 0.01%. Potential carcinogenicity
from vapor exposure to methylhydrazine was also
investigated in rats, dogs, hamsters, and mice. Exposures to
methylhydrazine at concentrations of 0.02 ppm (rats and
mice only) and 0.2, 2, and 5 ppm (rats and hamsters only)were conducted for 6 h/day, 5 days/week, for a year, followed
by observation for 1 year.
Environmental Fate
Biological. It was suggested that the rapid disappearance of methylhydrazine in sterile and
nonsterile soil (Arrendondo fine sand) under aerobic conditions was due to chemical oxidation.
Although the oxidation product was not identified, it biodegraded to carbon dioxide in the
nonsterile soil. The oxidation product did not degrade in the sterile soil (Ou and Street, 1988).
Versand/Shipping
UN1244 Methylhydrazine, Hazard class: 6.1;
Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid,
8-Corrosive material, Inhalation Hazard Zone A
l?uterung methode
Dry with BaO, then distil it in a vacuum. Store it under nitrogen. [Beilstein 4 IV 3322.]
Inkompatibilit?ten
May form explosive mixture with air.
Methyl hydrazine is a highly reactive reducing agent and a
medium strong base. May explode if heated. Violent reaction with strong oxidizers, such as fluorine, chlorine, combustibles, nitric acid; hydrogen peroxide. Incompatible with
acids, alcohols, glycols, isocyanates, phenols, cresols;
porous materials, such as earth, asbestos, wood and cloth.
Oxides of iron or copper, manganese, lead, copper or their
alloys can lead to fire and explosions. Attacks cork, some
plastics, coatings and rubber.
Waste disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations
governing storage, transportation, treatment, and waste
disposal. There are 2 alternatives: Dilute with water,
neutralize with sulfuric acid, then flush to sewer with
large volumes of water or incinerate with added flammable solvent in furnace equipped with afterburner and
alkaline scrubber.
Methylhydrazin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-METHYL-3-PHENYL-1H-PYRAZOLE-5-CARBALDEHYDE
ETHYL 1-METHYL-5-PROPYL-1H-PYRAZOLE-3-CARBOXYLATE
(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE
1-Methyl-5-propyl-1H-pyrazole-3-carboxylic acid amide ,97%
1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL
1,5-DIMETHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE
1-Methyl-3-propyl-1H-pyrazole-5-carboxamide ,97%
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE
2,2,2-TRIFLUORO-1-(3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)ETHANONE
4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
1,4,6-Trimethyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine ,97%
1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YLAMINE
1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
ETHYL 2-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
1-Methyl-3-propyl-1H-pyrazole-5-carbohydrazide ,97%
1,5-DIMETHYL-1H-PYRAZOLE-3-CARBONYL CHLORIDE
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE
1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID
5-AMINO-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
3-ETHYL-1-METHYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONITRILE
1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID
N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid
1-METHYL-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
5-Chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde
ETHYL 1-METHYL-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBOXYLATE
4-Bromo-1,3,5-trimethyl-1H-pyrazole
1,3,5-Trimethylpyrazole
1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
1-METHYL-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL
1,3-Dimethyl-5-hydroxypyrazole
Antipyrine
1-METHYL-5-PROPYL-1H-PYRAZOLE-3-CARBOXYLIC ACID
4-BROMO-1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE
Azimsulfuron
