5-Hydroxynicotinic acid
|
|
|
- CAS-Nr.
- 27828-71-3
- Englisch Name:
- 5-Hydroxynicotinic acid
- Synonyma:
- AKOS NCG-0022;5-Hydroxynicotinic;Nicotinic acid-004;TIMTEC-BB SBB010273;5-Hydroxynicotinic a;5-hydroxy-nicotinicaci;5-Hydroxy nicotic acid;5-HYDROXYNICOTINIC ACID;Hydroxynicotinicacid 5-;5-HydroxynicotinicAcid>
- CBNumber:
- CB7447677
- Summenformel:
- C6H5NO3
- Molgewicht:
- 139.11
- MOL-Datei:
- 27828-71-3.mol
|
5-Hydroxynicotinic acid Eigenschaften
- Schmelzpunkt:
- 299 °C
- Siedepunkt:
- 519.3±35.0 °C(Predicted)
- Dichte
- 1.485±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- Aggregatzustand
- powder to crystal
- pka
- 2.08±0.10(Predicted)
- Farbe
- White to Yellow
- BRN
- 115847
- InChI
- InChI=1S/C6H5NO3/c8-5-1-4(6(9)10)2-7-3-5/h1-3,8H,(H,9,10)
- InChIKey
- ATTDCVLRGFEHEO-UHFFFAOYSA-N
- SMILES
- C1=NC=C(O)C=C1C(O)=O
- CAS Datenbank
- 27828-71-3(CAS DataBase Reference)
5-Hydroxynicotinic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to off-white to yellow solid
Verwenden
5-Hydroxynicotinic acid is a nicotinic acid analog with potential inhibitory effect on the metabolism nicotinic acid by human platelets. Used in the investigation of the hydroxylation mechanism of the flaovoprotein 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO).
Research
5-hydroxynicotinic acid (5HNA) could be used as a model the following questions were addressed: (i) is it possible to promote the crystallization of a tautomeric form dominant in a specific solvent through solvate formation? (ii) Does that form persist if the memory of solvation is erased through thermal desolvation?
A thermodynamic analysis based on DSC and Calvet drop microcalorimetry results allowed us to rationalize these observations, indicating that (i) 5HNA·H2O is predicted to spontaneously lose water, even for a relative humidity of 100%, hence its robustness is most certainly of kinetical origin; (ii) 5HNA·DMSO is thermodynamically stable when a saturation DMSO pressure can be established over the sample, but becomes unstable when exposed to an atmosphere where the solvent is absent. The kinetically easier desolvation of 5HNA·DMSO compared to 5HNA·H2O may be related to the fact that water is isolated in the crystal lattice (isolated site hydrate) while DMSO is placed in channels (channel solvate)[1].
5-Hydroxynicotinic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-Hydroxynicotinic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 345)Lieferanten
27828-71-3()Verwandte Suche:
- 5-Hydroxypyridine-3-carboxylic acid, 3-Carboxy-5-hydroxypyridine
- 5-Hydroxy-pyridin-3-carboxylic acid
- Nicotinic acid, 5-hydroxy-
- 5-hydroxy-3-pyridinecarboxylicaci
- 5-hydroxy-nicotinicaci
- 3-PYRIDINECARBOXYLIC ACID, 5-HYDROXY-
- 5-HYDROXYNICOTINIC ACID
- 5-HYDROXYPYRIDINE-3-CARBOXYLIC ACID
- 5-HYDROXY-3-PYRIDINECARBOXYLIC ACID
- AKOS NCG-0022
- TIMTEC-BB SBB010273
- 5-Hydroxynicotinic
- 5-Hydroxynicotinic Acid ,98%
- 5-Hydroxy nicotic acid
- Hydroxynicotinicacid 5-
- 5-Hydroxynicotinic a
- 5-HydroxynicotinicAcid>
- 5-hydroxypyridine-3-carboxylicaci
- 5-Hydroxynicotinic acid ISO 9001：2015 REACH
- Nicotinic acid-004
- 27828-71-3
- 27828-77-3
- pharmacetical
- Pyridine series
- Carboxylic Acids
- Pyridine
- Organic acids
- Carboxylic Acids
- blocks
- Carboxes
- Pyridines
- Acids and Derivatives
- Heterocycles
- Nicotine Derivatives
- Pharmaceuticals
- Aromatics
- Intermediates & Fine Chemicals
