Interferon alfa-2b
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Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Giftige Stoffe Daten | 98530-12-2(Hazardous Substances Data) |
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Interferon alfa-2b Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Antineoplastic; biological response modifier.Indications
Interferon alfa-2b (Intron A) is a recombinant DNA product derived from the interferon alfa-2b gene of human white blood cells. Its mechanism of antitumor action involves binding to a plasma membrane receptor but is otherwise poorly understood. Its serum half-life is 2 to 3 hours after parenteral administration.Allgemeine Beschreibung
Interferon alfa-2b, Intron A, a water-soluble protein of165 amino acids and an approximate molecular mass of19,200 Da, is expressed from a recombinant strain of E. coli.This interferon molecule possesses an arginine at position23 and a histidine at position 34.Interferon alfa-2b is a broad-spectrum agent. It is indicatedfor hairy cell leukemia, condyloma acuminata (genital or venereal warts), AIDS-related Kaposi sarcoma, and chronichepatitis B and C infections.Intron A can be administered by the SC, IM, or IV routes,by infusion or by intralesional routes. The dose is 1 to 35 millionIU/day, depending on the application. The drug is suppliedas a solution or as a powder for solution, and both formscontain albumin, glycine, and sodium phosphate buffer.Hence, they should not be shaken. Vials of solution should bestored at 2°C to 8°C without freezing. The powder is stablefor 18 months at room temperature or 7 days at 45°C.Clinical Use
Interferon alfa-2b is useful in the treatment of a rare form of chronic leukemia, hairy cell leukemia, in which it produces remissions in 60 to 80% of patients. However, it has minimal antitumor activity in most human cancers.Remissions lasting a few months have been observed in 10 to 20% of patients with lymphomas, multiple myeloma, melanoma, renal cell carcinoma, and ovarian carcinoma.Nebenwirkungen
The adverse effects of interferon alfa-2b include fever and a flulike syndrome of muscle ache, fatigue, headache, anorexia, and nausea. Other less common side effects include leukopenia, diarrhea, dizziness, and skin rash.Interferon alfa-2b Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Interferon alfa-2b Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 9)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
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Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20274 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 |
cooperation@kean-chem.com | China | 40066 | 58 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12335 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 13675144456 |
sean.lv@synzest.com | China | 10784 | 58 |
Hubei Shishun Biotechnology Co. Ltd | 027-59223025 15107168801 |
1718480011@qq.com | China | 9850 | 58 |
Shaanxi Dideu Medichem Co. Ltd | 029-61856358 15229202216 |
1020@dideu.com | China | 10005 | 58 |
98530-12-2()Verwandte Suche:
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INTERFERON ALFA-2B
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- Interferon alfa-2b
- 98530-12-2
- C860H1353N229O255S9
- C16H17Cl3I2N3NaO5S