Hydroxychloroquine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Hydroxychloroquine is used to treat autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, in addition to malaria.
Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms.
Hydroxychloroquine is used to treat:
rheumatoid arthritis
discoid and systemic lupus erythematosus (SLE)
juvenile idiopathic arthritis (JIA).
Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits.
Definition
ChEBI: An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used
s the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Indications
Hydroxychloroquine (Plaquenil), like chloroquine, is a
4-aminoquinoline derivative used for the suppressive
and acute treatment of malaria. It also has been used for
rheumatoid arthritis and discoid and systemic lupus erythematosus.
Hydroxychloroquine has not been proved
to be more effective than chloroquine. Adverse reactions
associated with its use are similar to those described
for chloroquine.The drug should not be used in
patients with psoriasis or porphyria, since it may exacerbate
these conditions.
Mechanism of action
Hydroxychloroquine, like chloroquine, is also used for treating acute forms of malaria
caused by P. vivax, P. malariae, P. ovale, and also sensitive forms of P. falciparum. It is
also effective and safe like chloroquine, although it does not have obvious advantages. The
only advantage is that it is somewhat better tolerated. Its use is somewhat more limited
than chloroquine. Synonyms of this drug are plaquenil, quensyl, toremonil, and others.
Clinical Use
Hydroxychloroquine is approved for the treatment
of both systemic and cutaneous lupus erythematosus.
Both chloroquine and quinacrine (Atabrine) are also effective
in this skin disease. Low-dose chloroquine is
used for the therapy of porphyria cutanea tarda in patients
in whom phlebotomy has failed or is contraindicated.
Other skin diseases in which the drugs are useful
(after sunscreens and avoidance of sun exposure) include
polymorphous light eruption and solar urticaria.
Hydroxychloroquine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
