Otiloniumbromid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Otilonium is an inhibitor of L-type (IC₅₀ = 2.3 μM) and T-type calcium channels (IC₅₀s = 0.8, 1.1, and 0.4 μM for Ca_v3.1, Ca_v3.2, and Ca_v3.3, respectively). It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC₅₀s = 0.054, 0.4, 0.222, and 0.156 μM for M₁, M₂, M₄, and M₅ muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC₅₀ = 0.0552 μM). Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC₅₀ = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine . It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC₅₀ = 3.7 μM). Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.

Chemische Eigenschaften

White Powder

Verwenden

Otilonium bromide is an antimuscarinic

Allgemeine Beschreibung

Otilonium bromide is an antispasmodic. It contains a red color ACh (acetylcholine) like moiety bound to an aromatic system that ends with an octyl ether.

Sicherheitsprofil

Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Brí and NOx.

Otiloniumbromid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Otiloniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12795	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5858	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850	info@fortunachem.com	China	5986	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21639	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9218	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29886	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Beijing Yibai Biotechnology Co., Ltd	0086-182-6772-3597	sales04@yibaibiotech.com	CHINA	419	58

26095-59-0(Otiloniumbromid)Verwandte Suche:

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• Menoctyl
• N,N-Diethyl-N-methy-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]ethanaminium Bromide
• Pasminox
• SP-63
• Spasen
• Spasmoctyl
• Spasmome
• OTYLONIUMBROMIDE
• diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium bromide
• Aotixiuan
• OtioniuM BroMide
• OtiloniuM broMide(OctyloniuM broMide)
• Octylonium IodideDiscontinued See: O293250
• Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide (1:1)
• ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,p-(o-(octyloxy)benzamido)ben
• diethyl(2-hydroxyethyl)methylammoniumbromidep-(o-(octyloxy)benzamido)benzoa
• ethanaminium,n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)
• octylonium
• ottiloniobromuro
• n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)oxy)-ethanaminium bromide
• OCTYLONIUM IODIDE
• otilonium bromide
• diethyl(2-hydroxyethyl) methylammonium bromide p-(o-(octyloxy)benzamido)-benzoate
• Doralin
• diethyl-[2-[[4-[[(2-heptoxyphenyl)-oxomethyl]amino]phenyl]-oxomethoxy]ethyl]-methylammonium bromide
• aoixijan
• DORALIN;OCTYLONIUM BROMIDE;SP63;SPASMOMEN
• Otilonium bromide USP/EP/BP
• Otilonium bromideQ: What is Otilonium bromide Q: What is the CAS Number of Otilonium bromide Q: What is the storage condition of Otilonium bromide
• Otilonium
• Spasmomen
• OCTYLONIUM BROMIDE
• SPASMONEN
• Isoleucine Impurity 14
• 26095-59-0
• C29H43BrN2O4
• C29H43IN2O4
• C29H43N2O4Br
• BrC29H43N2O4
• Inhibitors
• Intermediates & Fine Chemicals
• Pharmaceuticals