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Rufinamide

Rufinamide Struktur
106308-44-5
CAS-Nr.
106308-44-5
Englisch Name:
Rufinamide
Synonyma:
1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide;E 2080;RUF 331;CS-1133;Inovelon;CGP 33101;Rufinamide;Rufinamide>Rufinamide, >=99%;Rufinamide(E 2080
CBNumber:
CB5972298
Summenformel:
C10H8F2N4O
Molgewicht:
238.19
MOL-Datei:
106308-44-5.mol

Rufinamide Eigenschaften

Schmelzpunkt:
232-234?C
Siedepunkt:
473.8±55.0 °C(Predicted)
Dichte
1.52±0.1 g/cm3(Predicted)
Flammpunkt:
2℃
storage temp. 
-20°C
L?slichkeit
DMSO: soluble9mg/mL
pka
14.37±0.50(Predicted)
Aggregatzustand
powder
Farbe
white
Merck 
14,8293
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,T
R-S?tze: 11-23/24/25-39/23/24/25-48-41-38-28
S-S?tze: 7-16-36/37-45-36/37/39-28-26-24/25
RIDADR  UN 1648 3 / PGII
WGK Germany  3
HS Code  29339900
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten R?umen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Rufinamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Approximately 2.5 million people worldwide are afflicted with epilepsy, a devastating neurological disorder diagnosed by the tendency toward recurrent, unprovoked seizures, often of unknown etiology. Rufinamide has been launched primarily as adjunctive therapy of LGS. Its proposed mechanism of action involves the limitation of firing of sodium-dependent action potentials. The ultimate result is membrane stabilization. Since it does not exhibit measurable binding to monoamine, acetylcholine, histamine, glycine, AMPA/kainate, NMDA, or GABA receptors or systems, these receptor-mediated pathways are not anticipated to be involved in the exertion of rufinamide’s effects. Rufinamide displayed efficacy in several electrical and chemical animal seizure models.

Chemische Eigenschaften

White Solid

Verwenden

Labelled Rufinamide (R701552). Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Anticonvulsant.

Allgemeine Beschreibung

An antiepileptic drug and anticonvulsant, Rufinamide is approved for the treatment of partial seizures associated with Lennox-Gastaut syndrome in adults and children 4 years and older. Rufinamide is marketed as Banzel® in the US and Inovelon® in the EU.

Biologische Aktivit?t

Board spectrum anticonvulsant. Prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons. Displays anticonvulsive activity in a range of animal seizure models.

Nebenwirkungen

Rufinamide was well tolerated with the most common adverse events including fatigue, somnolence, tremors, mild-to-moderate dizziness, nausea, headache, and diplopia. Since rufinamide is not metabolized by the CYP450 system, it is anticipated to have a low potential for interaction with drugs metabolized by the CYP isozymes. Rufinamide, however, does exhibit clinically relevant interactions with other antiepileptic drugs; concomitant treatment with valproate results in a reduction in rufinamide clearance while concomitant treatment with phenytoin, primidone, phenobarbital, carbamazepine, or vigabatrin causes an increase in rufinamide clearance. In these situations, rufinamide dosage adjustment may be required.

Rufinamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Rufinamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 289)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5893 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32024 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
Longyan Tianhua Biological Technology Co., Ltd
0086 18039857276 18039857276
CHINA 2783 58

106308-44-5()Verwandte Suche:


  • 1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE, 1-[(2,6-DIFLUOROPHENYL)METHYL]-
  • Rufinamide
  • Rufinamide (200 mg)
  • RufinaMide(Banzel)
  • CGP 33101
  • E 2080
  • Inovelon
  • RUF 331
  • Rufinamide solution
  • Rufinamide, >=99%
  • Rufinamide, 98%, a sodium channel blocker
  • 1-[(2,6-difluorophenyl)methyl]-4-triazolecarboxamide
  • CS-1133
  • Rufinamide(E 2080
  • CGP 33101; E 2080; INOVELON; RUF 331; BANZEL;E2080
  • Rufinamide>
  • Rufinamide USP/EP/BP
  • Rufinamide (CGP 33101
  • RufinamideQ: What is Rufinamide Q: What is the CAS Number of Rufinamide Q: What is the storage condition of Rufinamide Q: What are the applications of Rufinamide
  • TIANFU CHEM- Rufinamide
  • Rufinamide (1606401)
  • 5R)-Rosuvastatin Lactone
  • 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
  • Rufinamide/E2080/CGP33101/RUF331
  • CGP 33101|||E 2080|||RUF 331
  • 106308-44-5
  • C10H6D2F2N4O
  • C10H6D2F2N315NO
  • Inhibitors
  • Banzel
  • Pharmaceuticals
  • Isotope Labelled Compounds
  • Amines
  • Aromatics
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
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