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7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin Struktur
86639-52-3
CAS-Nr.
86639-52-3
Englisch Name:
7-Ethyl-10-hydroxycamptothecin
Synonyma:
SN38;7-ETHYL-10-HYDROXYCAMPTOTHECINE;Irinotecan Related CoMpound B;(S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione;(S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Irinotecan EP Impurity E/ Irinotecan Related Compound B (7-Ethyl-10-Hydroxy Camptothecin/ 11-Ethyl-9-Hydroxy Camptothecin);EHCPT;NK 012;SN-38:SN38;2H5]-SN-38
CBNumber:
CB5320664
Summenformel:
C22H20N2O5
Molgewicht:
392.4
MOL-Datei:
86639-52-3.mol

7-Ethyl-10-hydroxycamptothecin Eigenschaften

Schmelzpunkt:
217 °C
Siedepunkt:
810.3±65.0 °C(Predicted)
Dichte
1.51±0.1 g/cm3(Predicted)
Brechungsindex
21.5 ° (C=0.2, THF)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble1mg/mL
Aggregatzustand
powder
pka
9.13±0.40(Predicted)
Farbe
Off-white
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI
InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey
FJHBVJOVLFPMQE-QFIPXVFZSA-N
SMILES
N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS Datenbank
86639-52-3(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45
RIDADR  2811
WGK Germany  3
RTECS-Nr. UQ0491000
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  29399990
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H372 Sch?digt bei Hautkontakt und Verschlucken die Organe bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P314, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

7-Ethyl-10-hydroxycamptothecin Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Light-Yellow Solid

Verwenden

7-ethyl-10-hydroxycamptothecin (SN 38) is a metabolite of Irinotecan, a DNA topoisomerase inhibitor. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.

Definition

ChEBI: SN-38 (7-Ethyl-10-hydroxycamptothecin) is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an apoptosis inducer, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a drug metabolite and an antineoplastic agent. It is a pyranoindolizinoquinoline, a delta-lactone, a tertiary alcohol and a member of phenols.

Biologische Aktivit?t

Active metabolite of CPT-11 that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

7-Ethyl-10-hydroxycamptothecin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Irinotecan

7-Ethyl-10-hydroxycamptothecin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 651)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
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+8618381337976
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Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 +86-17332992504
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Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
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Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
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Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3009 60

86639-52-3()Verwandte Suche:

  • 7-10-hydroxycamptothecin
  • (4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
  • EHCPT
  • 7-Ethyl-10-hydroxy-CPT (Camptothecine), SN-38
  • 10-Hydroxycamptothecin acetate salt ,99%
  • Irinotecan Related Compound B (10 mg) ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
  • SN 38(7-Ethyl-10-hydroxycaMptothecin)
  • CaMptothecin, 7-ethyl-10-hydroxy (SN-38)
  • 7-Ethyl-10-hydroxy-20(S)-caMptothecin
  • (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 7-ETHYL-10-HYDRO(20)S-CAMPTOTHECIN
  • 7-Ethyl-10-Hydroxy Campothecin
  • 7-Ethyl-10-hydroxycamptothecin (TECANS)
  • 7-ethyl-10-hydrol-Camptothecin
  • 7-ETHYL-10-HYDROXYCAMPTTHECIN(SN38)
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-, (4S)-
  • 7-Ethyl-10-hydroxycamptothecin 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-7-Ethyl-10-hydroxycamptothecin
  • 7-Ethyl-10-hydroxycamptothecin, >=99%
  • Crude Glycyrrhetinic Acid
  • SN-38:SN38
  • NK 012
  • 7-etyl-10-hydroxycaMptothecin
  • 7,11-Diethyl-10- hydroxy-caMptothecin
  • Ethyl-10-hydroxycaMptoth
  • 11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • CaMptothecin 7-Ethyl-10-Hydroxy IMpurity
  • 7-ETHYL-10-HYDROXY-CPT
  • CAMPTOTHECIN, 7-ETHYL-10-HYDROXY
  • 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 10-dihydroxy-
  • 4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4,7-diethyl-1h-pyrano(3
  • 7-ethyl-10-hydroxy-captotheci
  • 7-Ethyl-10-hydroxycamptothecin(SN-38)
  • SN 38 Lactone
  • Irinotecan USP RC B
  • (4S)-4,11-Diethyl-4,9-Dihydroxy-1H-Pyrano[3,4
  • 6,7]Indolizino[1,2-B]Quinoline-3,14(4H,12H)-Dione
  • Irinotecan Impurity 15
  • 7-Ethyl-10-hydroxycamptothecin 86639-52-3
  • Irinotecan EP Impurity E
  • SN-38(NK-012)
  • (S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY E)
  • IRINOTECAN EP IMPURITY E ((S)-7-ETHYL-10-HYDROXY CAMPTOTHECIN)
  • (S)-4,11-diethyl-4,9-dihydroxy-1H-benzo[f]pyrano[4',3':4,5]pyrido[2,1-a]isoindole-3,14(4H,12H)-dione
  • (S)-7-Ethyl-10-hydroxy campthothecin
  • 7-ethyl-10-hydroxycamptothecin 80-98%
  • 7-Ethyl-10-hydroxycamptothecin>
  • 7-Ethyl-10-hydroxycamptothecin USP/EP/BP
  • SN-38 （Synonyms: NK012）
  • 7-Ethyl-1-hydroxycamptothecin
  • 7-Ethyl-10-HydroxycamptothecinQ: What is 7-Ethyl-10-Hydroxycamptothecin Q: What is the CAS Number of 7-Ethyl-10-Hydroxycamptothecin Q: What is the storage condition of 7-Ethyl-10-Hydroxycamptothecin Q: What are the applications of 7-Ethyl-10-Hydroxycamptothecin
  • 7-Ethyl-10-hydroxy-20(S)-campthothecin
  • Irinotecan Related Compound B ((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b] (1347631)
  • Irinotecan EP Impurity E/ Irinotecan Related Compound B (7-Ethyl-10-Hydroxy Camptothecin/ 11-Ethyl-9-Hydroxy Camptothecin)
  • SN38
  • 7-ETHYL-10-HYDROXYCAMPTOTHECINE
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