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Cefprozil

Cefprozil Struktur
92665-29-7
CAS-Nr.
92665-29-7
Englisch Name:
Cefprozil
Synonyma:
Procef;Prozef;Cefrozil;bmy28100;Cefprozi;CEFPROZIL;Cefprozile;Cephprozyl;Cefprozil-d4;cis-Cefprozil
CBNumber:
CB4739649
Summenformel:
C18H19N3O5S
Molgewicht:
389.43
MOL-Datei:
92665-29-7.mol

Cefprozil Eigenschaften

Schmelzpunkt:
215-217°C (dec.)
Siedepunkt:
803℃
Dichte
1.53±0.1 g/cm3(Predicted)
RTECS-Nr.
XI0339000
Flammpunkt:
>110°(230°F)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
DMF: 0.3 mg/ml; DMSO: 2.5 mg/ml; PBS (pH 7.2): 1.25 mg/ml
Aggregatzustand
Powder
pka
2.92±0.50(Predicted)
Wasserl?slichkeit
Soluble in DMSO at 10mg/ml. Insoluble in water.
BCS Class
3
InChIKey
WDLWHQDACQUCJR-PBFPGSCMSA-N
SMILES
N12[C@@]([H])([C@H](NC([C@H](N)C3=CC=C(O)C=C3)=O)C1=O)SCC(C=CC)=C2C(O)=O
CAS Datenbank
92665-29-7(CAS DataBase Reference)

Sicherheit

Cefprozil Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cefprozil is a new orally active cephalosporin useful in the treatment of otitis media, uncomplicated skin and skin structure infections plus upper/lower respiratory tract infections. Although structurally similar to cefadroxil, its spectrum of antibacterial activity is comparable to cefaclor, but exhibits greater activity against S.aureus, S. epidermidis, Listeria monocytogenes, Streptococci, H. influenzae, Propionibacterium acnes. Clostridium perfringens and difficile.

Chemische Eigenschaften

Pale Yellow Solid

Verwenden

Semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial

Definition

ChEBI: A semisynthetic, second-generation cephalosporin, with prop-1-enyl and (R)-2-amino-2-(4-hydroxyphenyl)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It is used to treat bronchitis as well as ear, skin and other bacterial infec ions.

Antimicrobial activity

Activity against Gram-positive cocci and Gram-negative bacilli is better than that of cefadroxil (which it structurally resembles) but is not as good as that of group 5 agents . It is moderately stable to hydrolysis by the common plasmid-mediated β-lactamases, but is hydrolyzed by the chromosomal enzymes of Gram-negative bacilli .

Hazard

Moderately toxic by ingestion. Human sys- temic effects.

Clinical Use

Cefprozil (Cefzil) is an orally active second-generationcephalosporin that is similar in structure and antibacterialspectrum to cefadroxil. Oral absorption is excellent (oralbioavailability is about 95%) and is not affected by antacidsor histamine H2-antagonists. Cefprozil exhibits greater invitro activity against streptococci, Neisseria spp., and S. aureusthan does cefadroxil. It is also more active than thefirst-generation cephalosporins against members of theEnterobacteriaceae family, such as E. coli, Klebsiella spp., P. mirabilis, and Citrobacter spp. The plasma half-life of1.2 to 1.4 hours permits twice-a-day dosing for the treatmentof most community-acquired respiratory and urinary tractinfections caused by susceptible organisms.

Nebenwirkungen

It is well tolerated. Diarrhea and gastrointestinal discomfort may occur. There have been a few reports of pseudomembranous colitis and serum sickness-like reactions.

Cefprozil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cefprozil Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 281)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Lewoo Pharmatech(Shanghai)Co.,Ltd
+86-15800805830 +86-15800805830
miao@lewoopharma.com.cn China 184 58
Shenzhen Excellent Biomedical Technology Co.,Ltd.
+86-0755-26050679 +86-15915472436
sale@ex-biotech.cn China 1031 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8813 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12840 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29884 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Hebei Runbin Biotechnology Co. LTD
13180553332
2179877681@qq.com CHINA 990 58

92665-29-7()Verwandte Suche:


  • (6R,7R)-7-[(2R)-2-AMINO-2-(4-HYDROXYPHENYL)ACETYLAMINO]-8-OXO-3-(1-PRO-PENYL)-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
  • Cefrozil
  • K690 Cefprozil
  • CEFPROZIL
  • bmy28100
  • (6r-(6-alpha,7beta(r*)))-l)acetyl)amino)-8-oxo-3-(1-propenyl)
  • Cefprozil-d4
  • (6R,7R)-7-[(2R)-2-aMino-2-(4-hydroxyphenyl)acetaMido]-8-oxo-3-[(1E)-prop-1-en-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • cis-Cefprozil
  • (6R,7R)-7-[(R)-2-Amino-2-(p-hydroxyphenyl)acetylamino]-8-oxo-3-(1-propenyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 8-[2-Amino-2-(4-hydroxyphenyl)-acetyl]amino-7-oxo-4-prop-1-enyl-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
  • CEFPROZIL:(6R,7R)-7-[(2R)-2-AMINO-2-(4-HYDROXYPHENYL)ACETYLAMINO]-8-OXO-3-(1-PRO-PENYL)-5-THIA-1-AZABICYLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID
  • (6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-(1-propen-1-yl)-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • Cefprozile
  • Cephprozyl
  • Procef
  • Prozef
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-amino(4-hydroxyphenyl)acetylamino-8-oxo-3-(1-propenyl)-, (6R,7R)-
  • (6R,7R)-7-[(2R)-2-Amino-2-(4-hydroxyphenyl) acetylamino]-8-oxo-3-(1-pro-penyl)-5-thia-1-azabicylo [4.2.0]oct-2-ene-2-carboxylic acid
  • (6R-(6alpha,7beta(R*)))-7-((Amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • (6S,7R)-7-((R)-2-Amino-2-(4-hydroxyphenyl)acetamido)-8-oxo-3-((E)-prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-(1-propen-1-yl)-, (6R,7R)-
  • Cefprozil USP/EP/BP
  • Cefprozil DISCONTINUED. Please see C243933.
  • Cefprozi
  • Cefprozil (Mixture of E,Z isomers)Q: What is Cefprozil (Mixture of E,Z isomers) Q: What is the CAS Number of Cefprozil (Mixture of E,Z isomers) Q: What is the storage condition of Cefprozil (Mixture of E,Z isomers) Q: What are the applications of Cefprozil (Mixture of E,Z isomers)
  • (6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-8-oxo-3-[(Z)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cefprozil - mix of Z (92%), and E (7%) isomers
  • Cefazolin propylene
  • Cefprozil (BMY-28100)
  • 92665-29-7
  • 156-1-46
  • 99-0-2
  • C18H19N3SH2O
  • C18H19N3O5S
  • API
  • cephalosporins
  • Aromatics
  • Heterocycles
  • Sulfur & Selenium Compounds
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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