Fibrinogene
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- CAS-Nr.
- 9001-32-5
- Bezeichnung:
- Fibrinogene
- Englisch Name:
- HUMAN FIBRINOGEN
- Synonyma:
- C00393;factor i;factor 1;Parenogen;FIBRINOGEN;fibrinogens;Fibrinogen HUMAN FIBRINOGEN;FIBRINOGEN TYPE I;BOVINE FIBRINOGEN
- CBNumber:
- CB4683502
- Summenformel:
- C6H14O6
- Molgewicht:
- 182.17176
- MOL-Datei:
- 9001-32-5.mol
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Fibrinogene Eigenschaften
- storage temp.
- -20°C
- L?slichkeit
- 0.9% NaCl: soluble
- Aggregatzustand
- powder
- Farbe
- white
- Biologische Quelle
- r at plasma
- Wasserl?slichkeit
- water: 25mg/mL
- EPA chemische Informationen
- Fibrinogens (9001-32-5)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
B |
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| WGK Germany |
3 |
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| F |
10-21 |
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| TSCA |
Yes |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P280,P302+P352, P312, P322, P363,P501 |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P322 |
Gezielte Ma?nahmen |
| P330 |
Mund ausspülen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Fibrinogene Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or grayish amorphous substance.
Verwenden
Diagnostic aid (vascular patency); radioactive agent.
Definition
A sterile fraction of normal human blood plasma, dried from the frozen state. In solution, it has the property of being converted into insoluble fibrin when thrombin is added. It is an essential factor in the blood-clotting mechanism.
Allgemeine Beschreibung
Fibrinogen, or Factor I, is a blood protein that is involved in clotting and is converted to fibrin by thrombin. Fibrinogen has an approximate molecular weight of 340 kDa
l?uterung methode
A likely impurity is plasminogen. It is purified by glycine precipitation [Mosesson & Sherry Biochemistry 5 2829 1966] to obtain fractions 1-2, then further purified [Blomb.ck & Blomb.ck Arkiv Kemi 10 415 1956] and contaminating plasminogen is removed by passage through a lysine-Sepharose column. Such preparations are at least 95% clottable as determined by Mosesson and Sherry's method (above ref.) in which the OD280 is measured before and after clotting with 5 Units/mL of thrombin (> 3000U/mg). All fibrinogen preparations are treated with calf intestinal alkaline phosphatase to convert any fibrinogen peptide-AP to fibrinogen peptide-A by removing serine-bound phosphate. Solutions are then lyophilised and stored at -20o. [Higgins & Shafer J Biol Chem 256 12013 1981.] It is sparingly soluble in H2O. Aqueous solutions are viscous with isoelectric point at pH 5.5. It is readily denatured by heating above 56o or by chemical agents, e.g. salicylaldehyde, naphthoquinone sulfonates, ninhydrin or alloxan. [Edsall et al. J Am Chem Soc 69 2731 1947, Purification: Cama et al. Naturwissenschaften 48 574 1961, Lorand & Middlebrook Science 118 515 1953, cf. Fuller in Methods Enzymol 163 474 1988.] For plasminogen-deficient fibrinogen from blood plasma, the anticoagulated blood is centrifuged and the plasma is frozen and washed with saline solution. It is treated with charcoal, freeze-thawed and dialysed versus Tris/NaCl buffer. [Maxwell & Nikel Biochemical Preparations 12 16 1968.]
Fibrinogene Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fibrinogene Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 194)Lieferanten
9001-32-5(Fibrinogene)Verwandte Suche:
Methylisocyanacetat
Dichloro(ethylendiamin)platin
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium
(Ethylenbis(nitrilomethylidyn)-2,2'-diphenolato)cobalt(II)
1,1,3,3-Tetramethylbutylisocyanat
(Pentan-2,4-dionato-O,O')silber
Ethylisocyanacetat
Benzylisocyanid
Aluminiumtris(2,4-pentandionato-O,O')
Phenylselenol
Kupfer(II)-4-oxopent-2-en-2-olat
Tris(pentan-2,4-dionato)eisen(II)
N-Butylisocyanid
(p-Toluolsulfonyl)methylisocyanid
Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium
2-Methylpropylisocyanid
- Fibrinogen from Bovine, fraction I
- Fibrinogen from bovine plasma,Factor I
- Fibrinogen froM huMan
- human fibrinogen dried
- Parenogen
- FIBRINOGEN, HUMAN PLASMA
- FIBRINOGEN, MOUSE PLASMA
- FIBRINOGEN, PIG PLASMA
- FIBRINOGEN, PLASMINOGEN-DEPLETED, HUMAN
- FIBRINOGEN, PLASMINOGEN-DEPLETED, HUMAN PLASMA
- FIBRINOGEN, RAT PLASMA
- FIBRINOGEN, DOG PLASMA
- FIBRINOGEN FRACTION 1
- FIBRINOGEN, FRACTION 1, BOVINE
- FIBRINOGEN, CAT PLASMA
- FIBRINOGEN, SALMON
- FIBRINOGEN, SHEEP PLASMA
- FIBRINOGEN TYPE I
- FIBRINOGEN TYPE III
- FIBRINOGEN TYPE I-S, BOVINE
- FIBRINOGEN TYPE IV, BOVINE
- COAGULATION FACTOR I
- COAGULATION FACTOR I, BOVINE
- COAGULATION FACTOR I, HUMAN
- BOVINE FIBRINOGEN
- Blood coagulation factor I
- FIBRINOGEN (BOVINE) (FRACTION 1)
- FIBRINOGEN FROM PIG PLASMA
- FIBRINOGEN, HUMAN (FRACTION I) FROM*HUMA N PLASMA
- FIBRINOGEN, HUMAN TYPE III FROM HUMAN*PL ASMA
- FIBRINOGEN TYPE IV: FROM BOVINE PLASMA
- FIBRINOGEN (FRACTION I) FROM CAT PLASMA
- FIBRINOGEN FROM SHEEP PLASMA
- FIBRINOGEN FROM GUINEA PIG PLASMA
- FIBRINOGEN AUS HUMANPLASMA*
- FIBRINOGEN FROM RAT PLASMA
- FIBRINOGEN FROM BABOON PLASMA
- FIBRINOGEN FROM BOVINE PLASMA
- FIBRINOGEN FROM DOG PLASMA
- FIBRINOGEN FROM MOUSE PLASMA
- FIBRINOGEN, HUMAN TYPE I FROM HUMAN*PLAS MA
- FIBRINOGEN TYPE I-S: FROM BOVINE PLASMA
- fibrinogens
- Fibrinogen
- from Bovine, fraction I
- FIBRINOGEN
- FIBRINOGEN, BOVINE
- FIBRINOGEN(BOVINE),FRACTION I
- FIBRINOGEN, BOVINE PLASMA
- FIBRINOGEN, HUMAN
- Fibrinogen,Bovine95%Clottable
- Fibrinogen,Human65%Clottable
- Fibrinogen,Rat60%Clottable
- Fibrinogen,Horse60%Clottable
- Fibrinogen,Dog60%Clottable
- Fibrinogen,Pig60%Clottable
- Fibrinogen,Bovine75%Clottable
- factor i
