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Felodipine

Felodipine Struktur
72509-76-3
CAS-Nr.
72509-76-3
Englisch Name:
Felodipine
Synonyma:
FEXOFENADINE HCL;Plendil;Felodipin;Agon;modip;Hydac;Spendil;CGH-869;P|endil;h154/82
CBNumber:
CB4300661
Summenformel:
C18H19Cl2NO4
Molgewicht:
384.25
MOL-Datei:
72509-76-3.mol

Felodipine Eigenschaften

Schmelzpunkt:
142-145°C
Siedepunkt:
471.5±45.0 °C(Predicted)
Dichte
1.3506 (rough estimate)
Brechungsindex
1.6500 (estimate)
storage temp. 
2-8°C
L?slichkeit
DMSO: 28 mg/mL
Aggregatzustand
solid
pka
2.73±0.70(Predicted)
Farbe
light yellow
Wasserl?slichkeit
insoluble
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI
InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey
RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES
C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
CAS Datenbank
72509-76-3(CAS DataBase Reference)
NIST chemische Informationen
Felodipine(72509-76-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 36
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS-Nr. US7968700
HS Code  29333990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

Felodipine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemische Eigenschaften

White or Light Yellow Crystalline Powder

Verwenden

Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Allgemeine Beschreibung

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biologische Aktivit?t

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

Felodipine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Felodipine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 506)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Hebei Jimi Trading Co., Ltd.
+86 319 5273535
bestoneforyou@sina.com CHINA 287 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58

72509-76-3()Verwandte Suche:


  • ,ethylmethylester
  • ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica
  • 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl ethyl ester
  • Fjodil:Hydac
  • P|endil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester
  • CGH-869
  • Spendil
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester
  • Felodipine,4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil
  • Felodipine (300 mg)
  • Felodipine (200 mg)
  • Felodipine/Plendil
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester
  • Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Felodipine, USP
  • Felodipine API
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • 3-ethyl 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Clevidipine Butyrate iMpurity Ⅱ
  • 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • Cleviprex Impurity E
  • Plendil, 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester
  • h154/82
  • modip
  • 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
  • FelodipineUsp25DmfGmp
  • 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil,
  • (RS)-Felodipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester
  • Agon
  • dl-Felodipine
  • Hydac
  • Munobal
  • Splendil
  • Felodipine
  • Felodipine (1269389)
  • FelodipineQ: What is Felodipine Q: What is the CAS Number of Felodipine Q: What is the storage condition of Felodipine Q: What are the applications of Felodipine
  • Felodipine (CGH869)
  • Felodipine USP/EP/BP
  • Hot selling high quality Felodipine
  • 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester
  • odipine
  • Felodipine>
  • Felodipine CRS
  • Felodipine, ≥98.0%
  • Felodipine, 98%, Selective L-type Ca2+ channel blocker
  • Clevidipine Butyrate Impurity 2
  • Felodipine, 98%, a selective L-type Ca2+ channel blocker
  • Clevidipine Impurity E
  • FEXOFENADINE HCL
  • Felodipin
  • Plendil
  • Felodipine in methanol
  • Felodipine in Acetonitrile
  • 72509-76-3
  • 72509-76-3;8618
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