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6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin

Pentetrazol Struktur
54-95-5
CAS-Nr.
54-95-5
Bezeichnung:
6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin
Englisch Name:
Pentetrazol
Synonyma:
PTZ;pentylenetetrazol;Tetrazol;Pentetrazole;PENTYLENETETRAZOLE;TT87;Su-Zol;Cortis;Corvis;Opticor
CBNumber:
CB4248615
Summenformel:
C6H10N4
Molgewicht:
138.17
MOL-Datei:
54-95-5.mol

6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin Eigenschaften

Schmelzpunkt:
59-61 °C (lit.)
Siedepunkt:
194 °C/12 mmHg (lit.)
Dichte
1.0617 (rough estimate)
Brechungsindex
1.4910 (estimate)
Flammpunkt:
194°C/12mm
storage temp. 
-20°C
L?slichkeit
≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O
Aggregatzustand
solid
pka
1.25±0.20(Predicted)
Farbe
White, crystalline powder
Sensitive 
Hygroscopic
Merck 
14,7141
BRN 
135492
Stabilit?t:
Stable. Incompatible with strong oxidizing agents.
InChIKey
CWRVKFFCRWGWCS-UHFFFAOYSA-N
CAS Datenbank
54-95-5(CAS DataBase Reference)
NIST chemische Informationen
Pentylenetetrazol(54-95-5)
EPA chemische Informationen
Pentetrazol (54-95-5)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25-36/37/38-23/24/25
S-S?tze: 26-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. XF8225000
TSCA  Yes
HazardClass  6.1
PackingGroup  II
Toxizit?t LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.

Chemische Eigenschaften

white crystalline powder

Verwenden

Non-specific CNS stimulant; convulsant; narcotic antagonist.

Definition

ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Allgemeine Beschreibung

White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.

Air & Water Reaktionen

Dust can be explosive when suspended in air at specific concentrations. Water soluble.

Reaktivit?t anzeigen

Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.

Brandgefahr

Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.

Biologische Aktivit?t

CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.

Sicherheitsprofil

A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.

l?uterung methode

pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]

6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 129)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683
mcbio_sales@163.com China 2251 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58

54-95-5(6,7,8,9-Tetrahydro-5H-tetrazolo-(1,5-a)azepin)Verwandte Suche:


  • Leptazole
  • Metalex-P
  • Metrazol
  • Nauranzol
  • Naurazol
  • Nedcardol
  • Neocardol
  • Neurazol
  • Novo cora-vinco
  • novocora-vinco
  • Opticor
  • Pemetesan
  • Penetiazol
  • Penetrasol
  • Penetratsol
  • Pentacard
  • Pentacor
  • Pentamethazol
  • Pentamethazolum
  • Pentamethylene-1,5-tetrazole
  • Pentamethylenetetrazol
  • 5-a)azepine,6,7,8,9-tetrahydro-5h-tetrazolo(
  • 5-a]azepine,6,7,8,9-tetrahydro-5h-tetrazolo[
  • 5H-Tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro-
  • 5H-Tetrazoloazepine, 6,7,8,9-tetrahydro-
  • 6,7,8,9-Tetrahydro-5-azepotetrazole
  • 6,7,8,9-Tetrahydro-5H-tetraazolo[1,5-a]azepine
  • 6,7,8,9-tetrahydro-5h-tetrazoloazepin
  • 7,8,9,10-tetrazabicyclo(5.3.0)-8,10-decadiene
  • 7,8,9,10-Tetrazabicyclo[5.3.0]deca-8,10-diene
  • Angiazol
  • Angioton
  • Angiotonin
  • Cardiazol
  • Cardifortan
  • Cardiol
  • Cardiotonicum
  • Cardosal
  • Cardosan
  • Cenalene-M
  • Cenazol
  • Centrazole
  • Cerebro-nicin
  • Coranormal
  • Coranormol
  • Corasol
  • Coratoline
  • Corazol
  • Corazole
  • Corazole (analeptic)
  • pentamethylene-tetrazol
  • Pentametilentetrazolo
  • Pentazol
  • Pentazolum
  • Pentemesan
  • Pentetrazol
  • Pentrazol
  • Pentrolone
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