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Fingolimod hydrochloride

Fingolimod hydrochloride Struktur
162359-56-0
CAS-Nr.
162359-56-0
Englisch Name:
Fingolimod hydrochloride
Synonyma:
Gilenya;FTY720;Fingolimod HCl;Fin;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;FY720;CS-290;FTY-720A;FTY720 . HCl;Fingolimod HC
CBNumber:
CB4244536
Summenformel:
C19H34ClNO2
Molgewicht:
343.93
MOL-Datei:
162359-56-0.mol

Fingolimod hydrochloride Eigenschaften

Schmelzpunkt:
102-107°C
storage temp. 
-20°C
L?slichkeit
water: soluble10mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige
Merck 
14,4083
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI
InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChIKey
SWZTYAVBMYWFGS-UHFFFAOYSA-N
SMILES
C1(C=CC(CCCCCCCC)=CC=1)CCC(N)(CO)CO.Cl
CAS Datenbank
162359-56-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38-52/53
S-S?tze: 26-61
WGK Germany  3
RTECS-Nr. TY3130000
HS Code  29221990
Toxizit?t LD50 orally in rats: 300-600 mg/kg (Troncoso)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P314 Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Fingolimod hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Approved by the U.S. FDA in September 2010, fingolimod (also referred to as FTY720) is the first approved oral therapy for the relapsing-remitting form ofmultiple sclerosis (RRMS). Because of fingolimod’s structural resemblance to sphingosine, a metabolite of sphingolipids that constitutes the cell membrane of all eukaryotic cells, it was hypothesized that fingolimod may be affecting sphingolipid metabolism in cells. A series of elegant in vitro and in vivo studies confirmed that fingolimod is converted to (S)-fingolimod phosphate primarily by sphingosine kinase- 2 and that (S)-fingolimod phosphate mediates multiple biological processes by binding to novel GPCR’s referred to as sphingosine-1-phosphate (S1P) receptors. S1P receptors are divided into five subtypes, S1P1–5, which have varying tissue and cellular distribution. S1P1–3 receptors are ubiquitously expressed in the immune, cardiovascular, and central nervous systems, S1P4 is restricted to the hematopoietic system, and S1P5 is mostly localized in the white matter of CNS. S1P1–3 receptors play important roles in endothelial barrier function, maintaining vascular tone, regulating heart rate and allowing for lymphocyte egress fromsecondary lymphoid organs. The functional role of S1P4 is unknown,while the S1P5 receptor is thought to be involved in natural killer cell trafficking and oligodendrocyte function.

Chemische Eigenschaften

White Solid

Verwenden

Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).

Definition

ChEBI: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).

Clinical Use

Fingolimod hydrochloride is an immunosuppressive drug developed by Novartis and approved in the U.S., Europe, and Australia in 2010 for the treatment of multiple sclerosis. The structure of fingolimod derives from the naturally-occurring myriocin (ISP-1) metabolite of the fungus I. sinclairii and the aminoalcohol functionality within the drug possesses structural similarity to the sphingosine family of natural products.

Fingolimod hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fingolimod hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 452)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd.
+86-0311-67591193 +8613931880626
sales02@dingminpharma.com China 252 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8807 58
Wuhan Haorong Biotechnology Co.,ltd
+86-18565342920; +8618565342920
sales@chembj.net China 289 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 474 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2986 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58

162359-56-0()Verwandte Suche:


  • Fingolimod (FTY720) hydrochloride
  • limod hydrochloride
  • fingolimod hydrochloride
  • 2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE
  • FTY720 HYDROCHLORIDE
  • 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol,HCl
  • Fingolimod HCL(FTY720)
  • 2-AMINO-2-[2-(4-OCTYLPHENYL)-ETHYL]-1,3-PROPANEDIOL
  • FingoliMod FTY120
  • FTY720 . HCl
  • FingoliMod (FTY720) HCl
  • 2-(4-octylphenethyl)-2-aminopropane-1,3-diol hydrochloride
  • 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride Fingolimod (FTY720) HCl
  • Fingolimod hydrochloride 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
  • Fingolimod (FTY-720A, FTY720)
  • FTY-720A
  • 1,3-Propanediol, 2-amino-2-(2-(4-octylphenyl)ethyl)-, hydrochloride
  • Unii-G926ec510t
  • FTY720(Fingolimod)
  • FY720
  • FTY720 B-0720
  • Fingolimod hydrochloride(FTY720)
  • FTY720(FingoliMod HCL)
  • Fingolimod hydrochlorid
  • 2-aMino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride
  • FTY720 hydrochloride, >=99%
  • Fingolimod HC
  • Tianfu Chem Fingolimod
  • Fingolimod hydrochloride USP/EP/BP
  • 2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride
  • 1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, hydrochloride (1:1)
  • Fingolimod Hydrochloride (300 mg)
  • FingolimodHydrochloride>
  • Fingolimod hydrochloride CRS
  • CS-290
  • GILENIA;FTY720;FTY 720
  • Fingolimod HLC
  • Fingolimod hydrochloride, 98%, S1P antagonist
  • Fin
  • FTY720
  • 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
  • Fingolimod HCl
  • Gilenya
  • Phingomode hydrochloride
  • 162359-56-0
  • 62359-55-9
  • C19H34ClNO2
  • C19H33NO2HCl
  • Pharmaceuticals
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Other APIs
  • API
  • Pharmaceutical intermediate
  • Inhibitors
  • Metabolites
  • All Inhibitors
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