Fingolimod hydrochloride
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Fingolimod hydrochloride Eigenschaften
- Schmelzpunkt:
- 102-107°C
- storage temp.
- -20°C
- L?slichkeit
- water: soluble10mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to beige
- Merck
- 14,4083
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
- InChIKey
- SWZTYAVBMYWFGS-UHFFFAOYSA-N
- SMILES
- C1(C=CC(CCCCCCCC)=CC=1)CCC(N)(CO)CO.Cl
- CAS Datenbank
- 162359-56-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xi | ||
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R-S?tze: | 36/37/38-52/53 | ||
S-S?tze: | 26-61 | ||
WGK Germany | 3 | ||
RTECS-Nr. | TY3130000 | ||
HS Code | 29221990 | ||
Toxizit?t | LD50 orally in rats: 300-600 mg/kg (Troncoso) |
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Fingolimod hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Approved by the U.S. FDA in September 2010, fingolimod (also referred to as FTY720) is the first approved oral therapy for the relapsing-remitting form ofmultiple sclerosis (RRMS). Because of fingolimod’s structural resemblance to sphingosine, a metabolite of sphingolipids that constitutes the cell membrane of all eukaryotic cells, it was hypothesized that fingolimod may be affecting sphingolipid metabolism in cells. A series of elegant in vitro and in vivo studies confirmed that fingolimod is converted to (S)-fingolimod phosphate primarily by sphingosine kinase- 2 and that (S)-fingolimod phosphate mediates multiple biological processes by binding to novel GPCR’s referred to as sphingosine-1-phosphate (S1P) receptors. S1P receptors are divided into five subtypes, S1P1–5, which have varying tissue and cellular distribution. S1P1–3 receptors are ubiquitously expressed in the immune, cardiovascular, and central nervous systems, S1P4 is restricted to the hematopoietic system, and S1P5 is mostly localized in the white matter of CNS. S1P1–3 receptors play important roles in endothelial barrier function, maintaining vascular tone, regulating heart rate and allowing for lymphocyte egress fromsecondary lymphoid organs. The functional role of S1P4 is unknown,while the S1P5 receptor is thought to be involved in natural killer cell trafficking and oligodendrocyte function.Chemische Eigenschaften
White SolidVerwenden
Fingolimod Hydrochloride is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. Fingolimod is reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).Definition
ChEBI: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).Clinical Use
Fingolimod hydrochloride is an immunosuppressive drug developed by Novartis and approved in the U.S., Europe, and Australia in 2010 for the treatment of multiple sclerosis. The structure of fingolimod derives from the naturally-occurring myriocin (ISP-1) metabolite of the fungus I. sinclairii and the aminoalcohol functionality within the drug possesses structural similarity to the sphingosine family of natural products.Fingolimod hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fingolimod hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 452)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. | +86-0311-67591193 +8613931880626 |
sales02@dingminpharma.com | China | 252 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8807 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 |
sales@chembj.net | China | 289 | 58 |
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 |
sales@sjar-tech.com | China | 474 | 58 |
Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 |
niki@zlchemi.com | China | 2986 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32956 | 60 |
Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
162359-56-0()Verwandte Suche:
Ethylacrylat
Ethanol
1-Methoxypropan-2-ol
Poly(propylene glycol)
ISOXADIFEN-ETHYL
Ethylacetat
Ethyl-4-hydroxybenzoat
Propan-1,2-diol
2,2'-(Propan-1,3-diyldiimino)bis[2-(hydroxymethyl)propan-1,3-diol]
Topotecan hydrochloride
2-Methoxy-1-methylethylacetat
Propane
Propan-1,3-diol
Hydrogenchlorid
Fingolimod hydrochloride
- Fingolimod (FTY720) hydrochloride
- limod hydrochloride
- fingolimod hydrochloride
- 2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE
- FTY720 HYDROCHLORIDE
- 2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol,HCl
- Fingolimod HCL(FTY720)
- 2-AMINO-2-[2-(4-OCTYLPHENYL)-ETHYL]-1,3-PROPANEDIOL
- FingoliMod FTY120
- FTY720 . HCl
- FingoliMod (FTY720) HCl
- 2-(4-octylphenethyl)-2-aminopropane-1,3-diol hydrochloride
- 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride Fingolimod (FTY720) HCl
- Fingolimod hydrochloride 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
- Fingolimod (FTY-720A, FTY720)
- FTY-720A
- 1,3-Propanediol, 2-amino-2-(2-(4-octylphenyl)ethyl)-, hydrochloride
- Unii-G926ec510t
- FTY720(Fingolimod)
- FY720
- FTY720 B-0720
- Fingolimod hydrochloride(FTY720)
- FTY720(FingoliMod HCL)
- Fingolimod hydrochlorid
- 2-aMino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride
- FTY720 hydrochloride, >=99%
- Fingolimod HC
- Tianfu Chem Fingolimod
- Fingolimod hydrochloride USP/EP/BP
- 2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride
- 1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, hydrochloride (1:1)
- Fingolimod Hydrochloride (300 mg)
- FingolimodHydrochloride>
- Fingolimod hydrochloride CRS
- CS-290
- GILENIA;FTY720;FTY 720
- Fingolimod HLC
- Fingolimod hydrochloride, 98%, S1P antagonist
- Fin
- FTY720
- 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride
- Fingolimod HCl
- Gilenya
- Phingomode hydrochloride
- 162359-56-0
- 62359-55-9
- C19H34ClNO2
- C19H33NO2HCl
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