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6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on

DIACYLGLYCEROL KINASE INHIBITOR I Struktur
93076-89-2
CAS-Nr.
93076-89-2
Bezeichnung:
6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on
Englisch Name:
DIACYLGLYCEROL KINASE INHIBITOR I
Synonyma:
DKI;DAGK;DGKE;DGKI;DAGK4;DAGK7;DGK-θ;R59022;DKGI-I;DAG KINASE
CBNumber:
CB3335279
Summenformel:
C27H26FN3OS
Molgewicht:
459.58
MOL-Datei:
93076-89-2.mol

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Eigenschaften

Siedepunkt:
619.8±65.0 °C(Predicted)
Dichte
1.26±0.1 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
0.1 M HCl: slightly soluble
Aggregatzustand
solid
pka
7.76±0.20(Predicted)
Farbe
pale yellow
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

S-S?tze: 23-24/25
WGK Germany  3

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

R-59-022 acts as an inducer of apoptosis in glioblastoma cells and avoids apoptosis in non-cancerous cells. This selectivity makes this drug a highly effective anti-cancer agent. Diacylglycerol Kinase inhibitor.

Biologische Aktivit?t

Diacylglycerol (DAG) kinase inhibitor (IC 50 = 2.8 μ M); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 69)Lieferanten
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
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Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
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Sigma-Aldrich 021-61415566 800-8193336
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EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58

93076-89-2(6-(2-(4-((4-Fluorphenyl)phenylme-thylen)-1-piperidinyl)ethyl)-7-methyl-5H-thiazol(3,2-a)pyrimidin-5-on)Verwandte Suche:

  • DIACYLGLYCEROL KINASE
  • DIACYLGLYCEROL KINASE INHIBITOR I
  • DIACYLGLYCEROL KINASE INHIBITOR I (R59 022)
  • DAGK
  • DAG KINASE
  • EC 2.7.1.107
  • EC: 2.7.1.107
  • DKI
  • SN-1,2-DIACYLGLYCEROL KINASE
  • SN-1,2-DIACYLGLYCEROL KINASE, RECOMBINANT, E COLI
  • R59022
  • DIACYLGLYCEROL KINASE FROM E. COLI
  • 6-[2-[4-[(4-fluorophenyl)phenylmethylene]-1-piperidin-yl]ethyl]-7-methyl-5h-thiazolo-[3,2-a]-pyrimidin-5-one
  • DIACYLGLYCEROL KINASE SOLUTION
  • R59022, 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one
  • Diacylglycerol Kinase from Escherichia coli
  • sn-1,2-Diacylglycerol kinase, DAGK
  • 5H-Thiazolo(3,2-A)pyrimidin-5-one, 6-(2-(4-((4-fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-
  • 6-(2-(4-((4-Fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-A)pyrimidine-5-one
  • 6-[2-[4-[(4-Fluorophenyl)phenylMethylene]-1-piperidin-yl]ethyl]-7-Methyl-5H-thiazolo-[3,2-a]-pyriMidin-5-one, R59022
  • DGKE
  • Anti-DGKQ, C-Terminal antibody produced in rabbit
  • DAGK4
  • DAGK7
  • DGK-θ
  • Anti-DGKI, C-Terminal antibody produced in rabbit
  • DGKI
  • Diglyceride kinase κ
  • Anti-DGKD, N-Terminal antibody produced in rabbit
  • 6-[2-[4-[(P-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO(3,2-A)PYRIMIDINE-5-ONE
  • 6-[2-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL)ETHYL]-7-METHYL-5H-THIAZOLO-[3,2-A]-PYRIMIDIN-5-ONE
  • 6-[2-[4-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
  • 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
  • Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem
  • DKGI-I
  • R 59022,R 59 022
  • 93076-89-2
  • Diacylglycerol kinase (DAGK)
  • Enzymes, Inhibitors, and Substrates
  • Signal Transduction
  • Serine/Threonine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cell Signaling Enzymes
  • Application Index
  • Biochemicals and Reagents
  • BioChemical
  • Lipid signaling
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