1-Methylindazole-3-carboxylic acid
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- CAS-Nr.
- 50890-83-0
- Englisch Name:
- 1-Methylindazole-3-carboxylic acid
- Synonyma:
- 1-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID;Granisetron Related CoMpound D;AKOS BB-9979;3-Dicyclohexylurea;TIMTEC-BB SBB000193;N'-Dicyclohexylurea;N-methylindazolic acid;Granisetron Impurity D;1-Methyl-indazole-3-acid;Granisetron EP impurity D
- CBNumber:
- CB2730011
- Summenformel:
- C9H8N2O2
- Molgewicht:
- 176.17
- MOL-Datei:
- 50890-83-0.mol
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1-Methylindazole-3-carboxylic acid Eigenschaften
- Schmelzpunkt:
- 213 °C
- Siedepunkt:
- 383.7±15.0 °C(Predicted)
- Dichte
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.14±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off White
- Wasserl?slichkeit
- Insoluble in water. Soluble in DMSO and Methanol.
- InChI
- InChI=1S/C9H8N2O2/c1-11-7-5-3-2-4-6(7)8(10-11)9(12)13/h2-5H,1H3,(H,12,13)
- InChIKey
- OVVDFORZEGKEJM-UHFFFAOYSA-N
- SMILES
- N1(C)C2=C(C=CC=C2)C(C(O)=O)=N1
- CAS Datenbank
- 50890-83-0(CAS DataBase Reference)
1-Methylindazole-3-carboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
Off White Solid
Verwenden
1-Methylindazole-3-carboxylic acid is used as important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as a pharmaceutical adjuvant, Granisetron Impurity D.
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 8448, 1998
DOI: 10.1021/jo981557o
Synthese
Calcium oxide (7.0 g, 0.124 mol, 2.0 molar equiv.) was added to technical methanol (150 ml), and the mixture was heated under reflux for 2 hours in a nitrogen atmosphere Indazole-3-carboxylic acid (10 g, 0.062 mol) was then added, and the reflux was continued for 2 hours. Dimethyl sulfate (15.6 g, 11.8 ml, 0.124 mole, 2.0 molar equiv.) was added dropwise under reflux for 2 hours, and the reflux continued for 2 hours. Water (100 ml) and 46% aqueous sodium hydroxide solution were added to produce a pH of about 14. Then, conc. hydrochloric acid was added to the reaction mixture to produce a pH of about 4. Calcium sulfate was collected by filtration and washed on a filter with hot methanol (3×30 ml). The methanol was removed under reduced pressure from the filtrate. The residuary mixture was stirred vigorously for 6 hours with a controlled pH of about 4. The solid product was collected by filtration, washed with water (3×30 ml), and dried in an oven at 50° C. overnight to give crude 1-Methylindazole-3-carboxylic acid.
1-Methylindazole-3-carboxylic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Methylindazole-3-carboxylic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 452)Lieferanten
50890-83-0()Verwandte Suche:
- 1-Methylindazole-3-carbox...
- Granisetron Related Compound D (15 mg) (1-methyl-1H-indazole-3-carboxylic acid)
- 1-Methyl INDAZOLE 3,CARBOXILIC ACID
- Methyl-1H-indazole-3-carboxyl
- 1-Methylindazole-3-carboxylicacid,97%
- 1-Methylindazole-3-carboxylic acid 97%
- 1-Methyl-1H-indazol-3-carboxylic acid
- 1-METHYLINDAZOLE-3-CARBOXYLIC ACID
- 1-METHYL-INDAZOLE-CARBOXYLIC-ACID
- MIC(1-methyl-indozole-3-carboxylicacid)
- METHYL-INDOZOLE-3-CARBOXYLIC ACID
- 1-Methylindazole-3-carboxylic acid ,98%
- 1-Methylindazole-3-carboxylic Acid (Granisetron Impurity D)
- 1-Methyl-indazole-3-acid
- 1-METHYL-3-INDAZOLECARBOXYLIC ACID
- AKOS BB-9979
- TIMTEC-BB SBB000193
- N-METHYL-(1H)INDAZOLE-3-CARBOXYLIC ACID
- N-METHYL-INDAZOLE-3-CARBOXYLIC ACID
- N-METHYL-INDOZOLE-3-CARBOXYLIC ACID
- 1-MethylIndazoleCarboxylicAcid(ForGranisetronHcl)
- 1-methylindazole-3-carboxylic acid (intermediate of granisetron)
- 1H-INDAZOLE-3-CARBOXYLIC ACID, 1-METHYL-
- Granisetron EP impurity D
- Granisetron Impurity 4（Granisetron EP Impurity D）
- Granisetron Impurity D hydrochloride
- N-methylindazolic acid
- Granisetron Impurity D
- 1-Methylindazole-3-carboxylicAcid>
- -methylindozole-3-carboxylic acid
- Granisetron Related Compound D (1-methyl-1H-indazole-3-carboxylic acid) (1298140)
- 3-Dicyclohexylurea
- N'-Dicyclohexylurea
- Granisetron Related CoMpound D
- 1-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID
- Granisetron USP Related Compound D
- Granisetron Hydrochloride EP Impurity D
- 1-Methyl-3-indole-3-carboxylic acid
- Granisetron Hydrochloride Impurity D
- 1-Methylindazole-3-carboxylic acid, 10 mM in DMSO
- 50890-83-0
- Building Blocks
- Heterocyclic Building Blocks
- Indazoles
- Heterocycles, Impurities, Indole Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Impurities
- Indole Derivatives
- Indoles and derivatives
- pharmacetical
- Carboxylic Acids
- Fused Ring Systems
- Building Blocks
- Heterocyclic Building Blocks
- Indazoles
- Benzene derivates
- Organic acids
