Flubendazol
CAS-Nr.
31430-15-6
Bezeichnung:
Flubendazol
Englisch Name:
Flubendazole
Synonyma:
FLUBENDAZOL;Flubendazole Polymorph B;R-17899;R 17889;FLUMOXAL;FLUBENOL;FLUVERNAL;FLUMOXANE;fluvermal;Flubenvet
CBNumber:
CB2669630
Summenformel:
C16H12FN3O3
Molgewicht:
313.28
MOL-Datei:
31430-15-6.mol
Flubendazol Eigenschaften
Schmelzpunkt:
290°C
Dichte
1.3720 (estimate)
storage temp.
2-8°C
L?slichkeit
Practically insoluble in water, in alcohol and in methylene chloride
pka
10.66±0.10(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Merck
14,4118
CAS Datenbank
31430-15-6(CAS DataBase Reference)
Sicherheit
Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)
R-S?tze:
22
S-S?tze:
44
WGK Germany
2
RTECS-Nr.
DD6497500
HS Code
29339900
Toxizit?t
LD50 in mice, rats, guinea pigs (mg/kg): >2560 orally (Thienpont)
Bildanzeige (GHS)
Alarmwort
Warnung
Gefahrenhinweise
Code
Gefahrenhinweise
Gefahrenklasse
Abteilung
Alarmwort
Symbol
P-Code
H361
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen.
Reproduktionstoxizit?t
Kategorie 2
Warnung
P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201
Vor Gebrauch besondere Anweisungen einholen.
P202
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P281
Vorgeschriebene pers?nliche Schutzausrüstung verwenden.
P308+P313
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405
Unter Verschluss aufbewahren.
P501
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.
Flubendazol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Flubendazole is a benzimidazole carbamate anthelmintic. It completely eliminates larvae in a mouse model of
A. cantonensis infection and exhibits a mean larval reduction of 100% in a
T. spiralis infection model when administered at doses of 5 and 50 mg/kg per day, respectively. Flubendazole inhibits mammalian tubulin polymerization (IC
50 = 2.5 μM) and inhibits binding of [
3 H]mebendazole to
H. contortus L3 larval tubulin (IC
50 = 0.17 μM). Flubendazole also inhibits the proliferation of BT-549, SK-BR-3, MDA-MB-231, and MCF-7 breast cancer cells (IC
50 s = 0.72, 1.51, 1.75, and 5.51 μM, respectively) and reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg.
Chemische Eigenschaften
White Solid
Verwenden
An anthelmintic.
Definition
ChEBI: A member of the class of mebendazole in which the benzoyl group is replaced by a p-fluorobenzoyl group. A broad-spectrum anthelmintic, it is used, particularly in veterinary medicine, for the treatment of nematodal infections.
Allgemeine Beschreibung
Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.
Flubendazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Flubendazol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 406)Lieferanten
Americas 1
Belgium 3
Brazil 3
Canada 3
China 301
Czech Republic 1
Europe 4
France 2
Germany 10
India 17
Japan 3
Mexico 1
Poland 1
South Korea 3
Spain 1
Switzerland 3
The Netherlands 1
United Kingdom 12
United States 34
Uruguay 1
Venezuela 1
Global 406
31430-15-6(Flubendazol)Verwandte Suche:
METHYL [5-(4-FLUOROBENZOYL)-1H-BENZIMIDAZOL-2-YL]CARBAMATE
CARBAMIC ACID, [5-(4-FLUOROBENZOYL)-1H-BENZIMIDAZOL-2-YL]-METHYL ESTER
FLUMOXAL
FLUMOXANAL
FLUMOXANE
FLUBENDAZOLE
FLUBENOL
FLUVERNAL
[5-(4-FLUOROBENZOYL)-1H-BENZIMIDAZOL-2-YL]CARBAMIC ACID, METHYL ESTER
(5-(4-fluorobenzoyl)-1h-benzimidazol-2-yl)-carbamicacimethylester
(5-(4-fluorobenzoyl)-1h-benzimidazole-2-yl)carbamicacidmethylester
[5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamic Acid Methyl Ester
Methyl [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamate
Flubendazole (FlutelMiuM)
flubendazole Solution, 100ppm
Flubendazole Imp. (EP)
Flubendazol, >=99%
[5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamic Acid Methyl Ester
Methyl [5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamate
5-(p-fluorobenzoyl)-2-benzimidazolecarbamicacimethylester
fluvermal
methyln-(5-(p-fluorobenzoyl)-2-benzimidazolyl)carbamate
5-(p-fluorobenzoyl)-2-benzimidazolecarbamic acid methyl este
[5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-,methyl ester
Flumoxanal, Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
5-(p-Fluorobenzoyl)-1H-benzimidazole-2-carbamic acid methyl ester
R-17899
5-(p-Fluorobenzoyl)-2-benzimidazolecarbamic acid, Methyl ester
flubendazole standard
Methyl (5-(4-fluorobenzoyl)-1H-benzo[d]iMidazol-2-yl)carbaMate
Flubenvet
Methyl (5-p-Fluorobenzoyl-2-benziMidazolyl)carbaMate
N-[6-(4-Fluorobenzoyl)-1H-benziMidazol-2-yl]carbaMic Acid Methyl Ester
NSC 313680
R 17889
Flubendazole PolyMorph B COS
N-[6-[(4-fluorophenyl)-oxomethyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
Flubendazole for system suitability CRS
Flubendazole CRS
Flubendazole>
ubendazoL
Carbamic acid, N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]-, methyl ester
Flubendazole Solution in DMSO, 1000μg/mL
Flubendazole USP/EP/BP
FLUBENDAZOL
Flubendazole Polymorph B
Flubendazole EP
Flumoxanal|||Flumoxane|||NSC 313680|||Fluvermal
Flubendazole in DMSO
Flubendazole in methanol
Flubendazole in Acetonitrile:DMF=1:1
Flubendazole 100 μg/ml Acetonitrile
C13678000 Flubendazole
31430-15-6
C16H12FN3O3
C16H12N3O3F
Fluorobenzene
Active Pharmaceutical Ingredients
31430-15-6