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N-Ethyl-alpha-methyl-3-(trifluor-methyl)benzolethanamin

FENFLURAMINE Struktur
458-24-2
CAS-Nr.
458-24-2
Bezeichnung:
N-Ethyl-alpha-methyl-3-(trifluor-methyl)benzolethanamin
Englisch Name:
FENFLURAMINE
Synonyma:
EQUINE;Acino;Pesos;S-768;C06996;Obedrex;Adipomin;Ponderex;Pondimin;Rotondin
CBNumber:
CB1325500
Summenformel:
C12H16F3N
Molgewicht:
231.26
MOL-Datei:
458-24-2.mol

N-Ethyl-alpha-methyl-3-(trifluor-methyl)benzolethanamin Eigenschaften

Schmelzpunkt:
170°C
Siedepunkt:
bp12 108-112°
Dichte
1.0950 (estimate)
storage temp. 
-20°C
L?slichkeit
Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand
Oil
pka
pKa 9.10 (Uncertain)
Farbe
Colourless to Pale Yellow
Stabilit?t:
Hygroscopic
CAS Datenbank
458-24-2
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher F,T
R-S?tze: 11-23/24/25-39/23/24/25
S-S?tze: 16-36/37-45
Giftige Stoffe Daten 458-24-2(Hazardous Substances Data)
Toxizit?t LD50 i.p. in mice: 144 mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P321 Besondere Behandlung
P330 Mund ausspülen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

N-Ethyl-alpha-methyl-3-(trifluor-methyl)benzolethanamin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anorexic.

Definition

ChEBI: A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reu take pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding ehavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertensio .

Weltgesundheitsorganisation (WHO)

Fenfluramine, dexfenfluramine and phentermine were approved individually more than 20 years ago in the USA for single-drug, short-term treatment of obesity. The manufacturers of fenfluramine and dexfenfluramine have since voluntarily withdrawn both products from the market worldwide. Phentermine remains available.

N-Ethyl-alpha-methyl-3-(trifluor-methyl)benzolethanamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

458-24-2(N-Ethyl-alpha-methyl-3-(trifluor-methyl)benzolethanamin)Verwandte Suche:


  • FENFLURAMINE
  • AURORA KA-7683
  • AURORA KA-7684
  • 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane
  • 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
  • Acino
  • Adipomin
  • N-Ethyl-1-[3-(trifluoromethyl)phenyl]-2-propanamine
  • N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine
  • Obedrex
  • Pesos
  • Phenethylamine, N-ethyl-alpha-methyl-m-(trifluoromethyl)-
  • Ponderax PA
  • Ponderex
  • Pondimin
  • Rotondin
  • ethyl(alpha-methyl-3-trifluoromethylphenethyl)amine
  • FENCLORIN
  • N-Ethyl-α-methyl-3-(tfifluoromethyl)benzeneethanamine
  • Phenfluoramine
  • n-ethyl-alpha-methyl-m-(trifluoromethyl)-phenethylamin
  • n-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine
  • Fenfluramin
  • N-Ethyl-3-trifluoromethyl-α-methylbenzeneethanamine
  • N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine
  • N-Ethyl-α-methyl-m-(trifluoromethyl)benzeneethanamine
  • dl-Fenfluramine
  • C06996
  • Methanol(Test Fenfluramine, 1.0 mg/mL)
  • Ponderal:Pon-derax
  • S-768
  • FenfluraMine API
  • Fenfluramine solution
  • Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-
  • FENFLURAMINE USP/EP/BP
  • Fenfluramine D6
  • EQUINE
  • 458-24-2
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