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Galantaminhydrobromid

Galantamine Hydrobromide Struktur
1953-04-4
CAS-Nr.
1953-04-4
Bezeichnung:
Galantaminhydrobromid
Englisch Name:
Galantamine Hydrobromide
Synonyma:
GALANTAMINE HBR;GALANTHAMINE HBR;NIVALIN;4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide;NIVALIN, HBR;Galanthamine HCI;GALANTAMINE HYDROBROMIDE;GALANTHAMIDE HYDROBROMIDE;GALANTHAMINE HYDROBROMIDUM
CBNumber:
CB2439815
Summenformel:
C17H22BrNO3
Molgewicht:
368.27
MOL-Datei:
1953-04-4.mol

Galantaminhydrobromid Eigenschaften

Schmelzpunkt:
256 °C
alpha 
D20 -93.1° (c = 0.1015 in 15 ml H2O)
Brechungsindex
-95 ° (C=1.4, H2O)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
Sparingly soluble in water, very slightly soluble in anhydrous ethanol. It dissolves in dilute solutions of alkali hydroxides.
Aggregatzustand
White to off-white crystalline solid.
Farbe
White to Orange to Green
Wasserl?slichkeit
Soluble in water or DMSO
Merck 
14,4340
InChI
InChI=1/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/s3
InChIKey
QORVDGQLPPAFRS-ORFATOSYNA-N
SMILES
[C@@]123CCN(C)CC4=CC=C(OC)C(O[C@H]1C[C@@H](O)C=C2)=C34.Br |&1:0,14,16,r|
LogP
1.750 (est)
CAS Datenbank
1953-04-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45-36/37/39-22
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. DF8075000
HazardClass  6.1
PackingGroup  II
HS Code  29399990
Toxizit?t LD50 i.v. in mice (mg/kg): 5.2 ± 0.2 (Friess)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Galantaminhydrobromid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.

Chemische Eigenschaften

Galantamine hydrobromide is a white to almost white powder and is sparingly soluble in water.

Verwenden

Galantamine hydrobromide (marketed as Reminyl) is one of a group of three drugs for people with Alzheimer's disease called cholinesterase inhibitors. The other two are called donepezil hydrochloride (common brand name Aricept) and rivastigmine (common brand name Exelon). It is a selective acetylcholinesterase inhibitor that for the treatment and prevention of Alzheimer's disease and other diseases resulting from reduced neuronal metabolism.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Galantamine Hydrobromide, a reversible, competitive acetyl cholinesterase inhibitor, is suggested for the remedy of mild to moderate dementia of the Alzheimer′s type.

Biologische Aktivit?t

Long-acting, centrally active acetylcholinesterase inhibitor (IC 50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β -amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Galantaminhydrobromid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Galantaminhydrobromid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 430)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12829 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325
 sales1@chuanghaibio.com China 5893 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971
 deasea125996@gmail.com China 2472 58
Sigma Audley 		+86-15937194204 +86-18126314766
 nova@sh-teruiop.com China 493 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +8613675893055
 info@hyper-chem.com China 295 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649
 sarah@tnjone.com China 1143 58
BINBO BIOLOGICAL CO.,LTD 		+8618629063126
 info@binbobiological.com China 346 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714
 fandachem@gmail.com China 9220 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479
sales@fine-chemtech.com CHINA 885 55

1953-04-4(Galantaminhydrobromid)Verwandte Suche:

  • (-)-Galanthaminium bromide
  • Hydrobromic acid·galanthamine
  • galanthamine hydrobromide from lycoris sp.
  • Galanthamine Hydrobromide Injection
  • GALANTHAMINE HYDROBROMIDUM
  • Lycorisradiata（l'.aher.)herb
  • Galanthamine hydrobromide from Lycoris sp.,Galantamine hydrobromide
  • Galantamine Hydrobromide (200 mg)
  • GALANTHAMINE HYDROBROMIDE(P)
  • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide
  • Galanthamine hydrobromide, >=99%
  • Galanthamine hydrobromide 99.7%
  • galantamine HBr 8% pellets
  • GALANTHAMIDE HYDROBROMIDE
  • NIVALIN, HBR
  • GALANTAMINE HYDROBROMIDE
  • Galantamine Hydrobromide Lycoremine 1953-04-4
  • Galanthamine HCI
  • GalantamineHydrobromide>
  • Galantamine racemic mixture CRS
  • Galantamine synthetic for system suitability CRS
  • Galantamine Hydrobromide,>98%
  • (4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol hydrobromide
  • Galantamine Hydrobromide USP/EP/BP
  • Galantamine Hydrobromide extrapure, 98%
  • Galantamine Hydrobromide (1287755)
  • GALANTAMINE HBR
  • 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-6H-BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-6-OL HYDROBROMIDE
  • NIVALIN
  • GALANTHAMINE HBR
  • (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, Hydrobromide
  • Galantamine hydrobromide in methanol
  • Galanthamine hydrobromide-RM
  • 1953-04-4
  • 4/4/1953
  • 19-45-3
  • C17H22BrNO3
  • C17H21NO3HBr
  • C17H21NO3xHBr
  • C17H21NO3HBrC17H22BrNO3
  • C17H22NO3Br
  • Alkaloids (Others)
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Cholinesterase
  • A to C
  • BioChemical
  • Biochemicals and Reagents
  • Alkaloids
  • Reminyl
  • Other APIs
  • API
  • Chiral Reagents
  • Pharmaceutical intermediates
  • Alkaloids
  • Alkaloids (Others)
  • Biochemistry
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