4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine
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- CAS-Nr.
- 42754-96-1
- Englisch Name:
- 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine
- Synonyma:
- 4,6-dichloro-2H-pyrazolo[3,4-d]pyrimidine;SKL327;6-Dichloro-1H-pyrazolo[3;4,6-dichloropyrrolo[2,3-d]pyrimidine;4,6-Dichloropyrazolo[3,4-d]pyriMidine;4,6-dichloro-1H-pyrazolo[3,4-d]pP03119ine;4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;4,6-Dichloro-1H-pyrazole[3,4-D]pyriMidine;1H-Pyrazolo[3,4-d]pyrimidine,4,6-dichloro-;4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(RS20012005)
- CBNumber:
- CB21215944
- Summenformel:
- C5H2Cl2N4
- Molgewicht:
- 189
- MOL-Datei:
- 42754-96-1.mol
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4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Eigenschaften
- Schmelzpunkt:
- 145 °C (decomp)
- Siedepunkt:
- 251.9±50.0 °C(Predicted)
- Dichte
- 2.02±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- solid
- pka
- 7.90±0.20(Predicted)
- Farbe
- Off-white to yellow
4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Yellow solid
Synthese
To a solution of 2,4,6-trichloropyrimidine-5-carbaldehyde (19.0 g, 990 mmol) in methanol (300 mL) was added drop-wise a solution of hydrazine monohydrate (4.8 mL) in methanol (80 mL) at 0 °C followed by drop-wise addition of triethylamine (13 mL) in methanol (80 mL) at 0 °C. The mixture was stirred at the same temperature for 30 mm. The solvent was removed, and the residue was purified by flash chromatography to afford 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine (10.3 g, 62 % yield) as a yellow solid. ‘H NMR (CDC13, 400IVIHz): 11.56 (br, 1H), 8.43 (s, 1H). MS m/z 190.68 [M+1].
4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 228)Lieferanten
- 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE
- 1H-Pyrazolo[3,4-d]pyrimidine,4,6-dichloro-
- 4,6-dichloropyrrolo[2,3-d]pyrimidine
- 4,6-Dichloro-1H-pyrazole[3,4-D]pyriMidine
- 4,6-Dichloropyrazolo[3,4-d]pyriMidine
- 6-Dichloro-1H-pyrazolo[3
- 4,6-dichloro-1H-pyrazolo[3,4-d]pP03119ine
- 4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE(RS20012005)
- SKL327
- 4,6-dichloro-2H-pyrazolo[3,4-d]pyrimidine
- 42754-96-1
- C5H2N4Cl2
- Aromatics
- Heterocycles
- Building Blocks
- Pyrazolo[x,x-y]pyridine
- Heterocycle-Pyrimidine series
- CHIRAL CHEMICALS
