Glibenclamid
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Glibenclamid Eigenschaften
- Schmelzpunkt:
- 173-175°C
- Dichte
- 1.1805 (rough estimate)
- Brechungsindex
- 1.6100 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- ethanol: soluble2mg/mL
- Aggregatzustand
- White solid
- pka
- 5.3(at 25℃)
- Farbe
- White
- Wasserl?slichkeit
- Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.
- Merck
- 14,4478
- BCS Class
- 2
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N
- CAS Datenbank
- 10238-21-8(CAS DataBase Reference)
- NIST chemische Informationen
- Glyburide(10238-21-8)
- EPA chemische Informationen
- Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy- (10238-21-8)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | Xn | ||
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R-S?tze: | 20/21/22 | ||
S-S?tze: | 22-36/37/39-36-24/25 | ||
WGK Germany | 2 | ||
RTECS-Nr. | YS4725200 | ||
HS Code | 29350090 | ||
Toxizit?t | LD50 in rats and mice (g/kg): >20 orally; >12.5 i.p.; >20 s.c. (Mizukami) |
Bildanzeige (GHS) | |||||||||||||||
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Alarmwort | Achtung | ||||||||||||||
Gefahrenhinweise |
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Sicherheit |
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Glibenclamid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powderVerwenden
Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 ?M).Definition
ChEBI: An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.Allgemeine Beschreibung
Glyburide (glibenclamide) is 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide; this compound can also be named asthe urea—see preceding discussion (Diabeta, Glynase,generic). Some tablet formulations contain micronized drug(formerly Micronase, now only generic). Combinations areavailable with metformin in the United States (Glucovance,generic; tablets, mg glipizide/mg metformin as hydrochloride:1.25/250, 2.5/500, 5/500).Biologische Aktivit?t
ATP-dependent K + channel (K ATP ) and CFTR Cl - channel blocker. Inhibits K ATP currents in the pancreas, causing an increase in intracellular Ca 2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC 50 of 20 μ M.Mechanism of action
This drug belongs to the second-generation sulfonylurea derivatives. Like all of the other oral hypoglycemic drugs examined, it is a β-cell stimulant in pancreas; but on the other hand, it increases the sensitivity to insulin, the degree to which it binds with target cells. At the same time, it differs in that it is easier to tolerate. The hypoglycemic effect sets in at significantly lower doses than with first-generation drugs.Glibenclamid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Glibenclamid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 676)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5975 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5889 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Rixing Chemical CO.,LTD | +86-13237129059 -13237129059 |
sales@rixingchemi.com | CHINA | 229 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29880 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
10238-21-8(Glibenclamid)Verwandte Suche:
Glichidon
Acetohexamid
Glycyclamid
Glibenclamid
Formamid
Cyclohexylharnstoff
o-Anisamid
Metahexamid
Glipentid
- LABOTEST-BB LT00244861
- GLIBENCLAMIDE
- GLYBURIDE USP
- GlibenclamideGlibenclamideBp
- 5-CHLORO-N-[4-(CYCLOHEXYLUREIDOSULFONYL)PHENETHYL]-2-METHOXYBENZAMIDE
- 5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]-SULFONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE
- adiab
- azuglucon
- bastiverit
- Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
- Daonil
- Diabiphage
- duraglucon
- euclamin
- Euglucan
- Euglucon
- Euglucon 5
- euglucon5
- Euglykon
- Gilemal
- lederglib
- l-harnstoff
- libanil
- lisaglucon
- Malix
- Maninil
- n-(4-(2-(5-chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-n’-cyclohexylurea
- N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
- n-(4-(beta-(2-methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-n’-cyclohexy
- N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
- praeciglucon
- 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide, Adiab, Azuglucon, Bastiverit, Glibenclamide, Glidiabet, Glimidstada,
- N-{4-[2[(5-Chloro-2-methoxybenzamino)ethyl]-phenysulphonyl}-N-cyclohexyl moyev
- Glyburide, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-Nμ-cyclohexylurea, 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
- Glybenclamide, Glyburide, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-Nμ-cyclohexylurea, 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide
- 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methyoxybenzamide
- 1-[p-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]phenylsulfonyl]-3-cyclohexylurea
- Glybenclamide,5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide, Glyburide, N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea
- Glyburide (200 mg)
- Glyburide (200 mg)G1C3470.990mg/mg(dr)
- Glibenelamide
- Glyburide/GliebenclaMide
- GlybenclaMide, GlibenclaMide, INN, glyburide, 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-MethoxybenzaMide, Glyburide, N-p-[2-(5-Chloro-2-MethoxybenzaMido)ethyl]benzenesulfonyl-N'-cyclohexylurea
- Glyburide(Diabeta)
- 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
- 5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]SULPHONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE
- N-P-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]BENZENESULFONYL-N'-CYCLOHEXYLUREA
- Abbenclamide
- Glibadone
- Glidenclamide
- glidiabet
- glucoremed
- HB 419
- hb419
- HD 419
- hd419
- hemi-daonil
- semi-daonil