Eletriptan
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- CAS-Nr.
- 143322-58-1
- Englisch Name:
- Eletriptan
- Synonyma:
- Relpax;UK-116044;ELETRIPTAN;(R)-Eletriptan;Unii-22qoo9B8ki;Relpax free aMine;Eletriptan Free Base;Eletriptan USP/EP/BP;According to triptans;Eletriptan Impurity 6
- CBNumber:
- CB1404591
- Summenformel:
- C22H26N2O2S
- Molgewicht:
- 382.52
- MOL-Datei:
- 143322-58-1.mol
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Eletriptan Eigenschaften
- Schmelzpunkt:
- 168-170?C
- Siedepunkt:
- 613.4±55.0 °C(Predicted)
- Dichte
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 17.14±0.30(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Pale Yellow to Dark Yellow
- Stabilit?t:
- Hygroscopic
- InChI
- InChI=1S/C22H26N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3/t19-/m1/s1
- InChIKey
- PWVXXGRKLHYWKM-LJQANCHMSA-N
- SMILES
- N1C2=C(C=C(CCS(C3=CC=CC=C3)(=O)=O)C=C2)C(C[C@H]2CCCN2C)=C1
- CAS Datenbank
- 143322-58-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Eletriptan Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Yellow Foam
Verwenden
Eletriptan is a selective serotonin 5-HT1B and 5-HT1D receptor agonist and used to treat migraines (1,2,3).
Definition
ChEBI: Eletriptan is an N-alkylpyrrolidine, being N-methylpyrrolidine in which the pro-R hydrogen at position 2 is substituted by a {5-[2-(phenylsulfonyl)ethyl]-1H-indol-3-yl}m
thyl group.
Allgemeine Beschreibung
Eletriptan, introduced into the market in 2002, is the newesttriptan with highest affinity for 5-HT1B, 5-HT
1D, and 5-HT
1Freceptors. It is one of the most lipophilic triptans marketedto date and is well tolerated and safe across its dosing rangeof 20 to 80 mg. However, it is metabolized primarily(>90%) by CYP3A4 isozyme to its active metabolite, theN-desmethyleletriptan, which accounts for approximately10% to 20% of the plasma concentration of that observedfor parent drug. Thus, coadministration of eletriptan withpotent CYP3A4 inhibitors such as ketoconazole, itraconazole,nefazodone, troleandomycin, clarithromycin, ritonavir,and nelfinavir may require dose reduction and closer monitoringfor CNS side effects. Furthermore, becauseeletriptan and its active metabolite, N-desmethyleletriptan,are also substrates for the P-glycoprotein efflux pumps thatare responsible for their removal from the brain, coadministrationof eletriptan with a known P-glycoprotein inhibitorand/or inducer such as digoxin, diltiazem, verapamil, or St.John’s Worth would result in higher brain levels of its activemetabolite, and thus a higher rate of the CNS side effectsreported for this drug.
Eletriptan Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Eletriptan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 145)Lieferanten
143322-58-1()Verwandte Suche:
- (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-Indole
- (R)-5-[2-(Benzenesulfonyl)ethyl]-3-[(N-methylpyrrolidin-2-yl)methyl]-1H-indole
- Eletriptan
Also see: R143400
- Eletriptan Free Base
- Relpax free aMine
- 3-benzyl-5-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indol-3-yl)-1,2,4-oxadiazole
- 5-[2-(benzenesulfonyl)ethyl]-3-{[(2R)-1-Methylpyrrolidin-2-yl]Methyl}-1H-indole
- 1H-Indole,3-[[(2R)-1-Methyl-2-pyrrolidinyl]Methyl]-5-[2-(phenylsulfonyl)ethyl]-
- According to triptans
- 5-[2-(benzenesulfonyl)ethyl]-3-[1-methylpyrrolidin-2(R)-ylmethy] -1H-indole
- (R)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole
- ELETRIPTAN
- 3-[(1-methylpyrrolidin-2-yl)methyl]-5-(2-phenylsulfonylethyl)-1h-indole
- 5-(2-(Benzenesulfoyl)vinyl)-3-(1-Methylpyrrolidin-2(R)-ylmethyl)-1H-Indole
- EletriptanHydrobromide(ForR&DOnly)
- UK-116044,Relpax,3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole
- 5-(2-(BENZENESULFONYL)VINYL)-3-(1-METHYLPYRROLIDIN-2(R)-YLMETHYL)-1H-INDOLE
- 3-[[(R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]indolemonohydrobromide
- 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole
- UK-116044
- 1H-Indole, 3-(((2R)-1-methyl-2-pyrrolidinyl)methyl)-5-(2-(phenylsulfonyl)ethyl)ethyl)-
- Unii-22qoo9B8ki
- (R)-Eletriptan
- Eletriptan USP/EP/BP
- Tianfu Chem Eletriptan
- Eletriptan
(UK 116044)
- 5-[2-(benzenesulfonyl)ethyl]-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole
- Eletriptan Impurity 6
- 5-[2-(benzenesulfonyl)ethyl]-3-[(1-Methylpyrrolidin-2-yl)Methyl]-1H-indole
- Relpax
- UK-116,044-04 [as hydrobromide]
- 143322-58-1
- C22H26N2O2S
- API
- Pfizer compounds
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- APIs
- Pharmaceutical material and intermeidates
