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Zileuton

Zileuton Struktur
111406-87-2
CAS-Nr.
111406-87-2
Englisch Name:
Zileuton
Synonyma:
ZYFLO;Zyfl;Leutml;ABT-077;Leutrol; A-64077;ZILEUTON;CGS-23622;Griluto-CR;AKOS 91253
CBNumber:
CB1344903
Summenformel:
C11H12N2O2S
Molgewicht:
236.29
MOL-Datei:
111406-87-2.mol

Zileuton Eigenschaften

Schmelzpunkt:
157-158°C
Siedepunkt:
449.4±47.0 °C(Predicted)
Dichte
1.401±0.06 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO: ≥20mg/mL at ~60°C (warm up to 60 C for 5min)
pka
pKa 10.3(H2O t undefined I undefined) (Uncertain)
Aggregatzustand
powder
Farbe
white to off-white
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS Datenbank
111406-87-2(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-36
S-S?tze: 26
WGK Germany  1
HS Code  2934990002
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Zileuton Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 μM. Zileuton inhibits leukotriene B4 (LTB4; ) production induced by the calcium ionophore A23187 in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 μM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge. Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.

Chemische Eigenschaften

Crystalline Solid

Definition

ChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT , and LTE4. It is used for the management of chronic asthma.

Biologische Aktivit?t

Orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB 4 synthesis (IC 50 values are 0.56, 2.3 and 2.6 μ M in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC 50 = 6 μ M) and exhibits antiasthmatic activity in vivo . Also weakly inhibits CYP1A2 (K i = 66 - 98 μ M).

Zileuton Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Zileuton Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 354)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58

111406-87-2()Verwandte Suche:


  • Zileuton and its intermediates
  • A-64077
  • Abbott 64077
  • Leutrol
  • Zyfl
  • 1-(1-(BENZO[B]THIOPHEN-2-YL)ETHYL)-1-HYDROXYUREA
  • Leutml
  • N-(1-Benzolb]thien-2-ylethyl)。N-hydroxyurea
  • 1-[1-(1-Benzothiophen-2-yl)ethyl]-1-hydroxyurea
  • 1-Hydroxy-1-[1-(benzo[b]thiophene-2-yl)ethyl]urea
  • ABT-077
  • CGS-23622
  • Zileuton (150 mg)
  • ZYFLO (zileuton)
  • 1-[(1S)-1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
  • N-(1-bezo[b]thien-2-yl-ethyl)-N-hydroxy-urea
  • Griluto-CR
  • Zileuton 1-(1-Benzothiophen-2-ylethyl)-1-hydroxy-urea
  • Zileuton, >=99%
  • Zileuton (Zilpaterol)
  • ZILEUTON
  • AKOS 91253
  • 1-(1-benzothiophen-2-ylethyl)-1-hydroxy-urea
  • Qi Liu Tong
  • High quality USP 39/EP 9.0 /BP 2012 GMP DMF FDA Zileuton producer
  • Zileuton USP/EP/BP
  • Zileuton (A 64077
  • ZileutonQ: What is Zileuton Q: What is the CAS Number of Zileuton Q: What is the storage condition of Zileuton Q: What are the applications of Zileuton
  • "Zileuton-13C2,15N"
  • Zileuton (1724656)
  • ZYFLO
  • 111406-87-2
  • 11406-87-2
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  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Amines
  • Aromatics
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  • Antiasthmatic
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  • API
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