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3-Methyl-1-phenyl-5-pyrazolon

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Struktur
89-25-8
CAS-Nr.
89-25-8
Bezeichnung:
3-Methyl-1-phenyl-5-pyrazolon
Englisch Name:
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
Synonyma:
PMP;EDARAVONE;1-Phenyl-3-methyl-5-pyrazolone;5-METHYL-2-PHENYL-2,4-DIHYDRO-3H-PYRAZOL-3-ONE;3-methyl-1-phenyl-1H-pyrazol-5(4H)-one;Norphenazone;3-METHYL-1-PHENYL-5-PYRAZOLONE;3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE;MONOPYRAZOLONE;PHENYLMETHYLPYRAZOLON
CBNumber:
CB1287462
Summenformel:
C10H10N2O
Molgewicht:
174.2
MOL-Datei:
89-25-8.mol

3-Methyl-1-phenyl-5-pyrazolon Eigenschaften

Schmelzpunkt:
126-128 °C(lit.)
Siedepunkt:
287 °C265 mm Hg(lit.)
Dichte
1,12 g/cm3
Dampfdruck
0.016Pa at 20℃
Brechungsindex
1.6300 (estimate)
Flammpunkt:
191°C/17mm
storage temp. 
2-8°C
L?slichkeit
3.30g/l
Aggregatzustand
Crystalline Powder
pka
2.73±0.50(Predicted)
Farbe
Yellow to beige
PH
4.0-4.4 (H2O, 20℃)(saturated aqueous solution)
Wasserl?slichkeit
3 g/L (20 ºC)
Merck 
14,6713
BRN 
609575
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
LogP
0.75 at 24℃
CAS Datenbank
89-25-8(CAS DataBase Reference)
NIST chemische Informationen
3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-(89-25-8)
EPA chemische Informationen
1-Phenyl-3-methyl-5-pyrazolone (89-25-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  1
RTECS-Nr. UQ9625000
TSCA  Yes
HS Code  29331990
Giftige Stoffe Daten 89-25-8(Hazardous Substances Data)
Toxizit?t LD50 orl-rat: 3500 mg/kg LONZA# 08FEB79
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

3-Methyl-1-phenyl-5-pyrazolon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Edaravone was marketed in Japan for improving neurologic recovery following acute brain infarction. Currently, several agents classified as neuroprotectants and acting by diverse mechanisms (inhibition of glutamate release, blockade of calcium channels, lazaroids) have been marketed for treating the outcomes of brain damage due to trauma, ischemia or cardiac arrest. Edavarone is the first antioxidant with free radical scavenging activity to be introduced for this pathology. This previously described molecule (in particular as norantipyrine, one of three metabolites of antipyrine in mammals) can be simply prepared by direct cyclization of phenylhydrazine with alkylacetoacetate. Edarevone is a lipophilic agent, readily accessible to brain tissue, that is capable of reducing edema in the brain following ischemia by blocking the arachidonic acid cascade triggering peroxidative neurodegeneration. Interestingly, this agent has been shown to quench active oxygen species in endothelial cell homogenate, as well as inhibiting in vitro lipid peroxidative disintegration of membranes, so making this compound effective during reperfusion following ischemic injury. As an additional indication, phase III trials started with edaravone for increasing the chance of recovery after subarachnoid hemorrhage.

Chemische Eigenschaften

Off white to light yellow powder

Verwenden

Edaravone inhibits the disease activity in rheumatoid arthritis.

Definition

ChEBI: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.

Allgemeine Beschreibung

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore.

Hazard

Toxic by ingestion.

Biologische Aktivit?t

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity.

Sicherheitsprofil

Moderately toxic by ingestion andintraperitoneal routes. An eye irritant. When heated todecomposition it emits toxic fumes of NOx.

l?uterung methode

Crystallise the pyrazolone from hot H2O, EtOH or EtOH/water (1:1). It complexes with metals. [Veibel et al. Acta Chim Scand 6 1066 1952, Beilstein 24 II 9, 24 III/IV 71.]

3-Methyl-1-phenyl-5-pyrazolon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3-Methyl-1-phenyl-5-pyrazolon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 898)Lieferanten
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89-25-8(3-Methyl-1-phenyl-5-pyrazolon)Verwandte Suche:


  • 3-METHYL-1-PHENYL-5-PYROZOLENE
  • AKOS B029819
  • developerz
  • Methylphenylpyrazolone
  • NCI-C03952
  • norantipyrine
  • NSC-12
  • NSC-26139
  • NSC-2629
  • 1-Phenyl-3-methyl-5-pyrazolon
  • 1-Phenyl-3-methylpyrazolone
  • 1-Phenyl-3-methylpyrazolone-5
  • 1-Phenyl-3-methyl-2-pyrazolin-5-one
  • 1-Phenyl-3-methyl-5(4H)-pyrazolone
  • 3-Methyl-1-phenyl-5(4H)-pyrazolone
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one,99%
  • 1-Phenyl-3-methyl-5-pyrazalone PMP
  • 1-pheny-3-methyl-5-pyrazolone
  • 1-pheny-3-methyl-5-p
  • 3-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one, 99% 100GR
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one, 99% 5GR
  • 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-o
  • 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE FOR
  • Edaravone (MCI-186)
  • Monopyrazolone Edaravone
  • 1-pheny-3-Methyl-5-pyrazolone (PMP)
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one (Edaravone)
  • 3-Methyl-1-phenyl-2-pyrazoline-5-one 99%
  • ORGANIC DYE INTERMEDIATES 1-PHENYL 3-METHYL-5 PYRAZOLONE (PMP)
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one for synthesis
  • 5-Methyl-2-phenyl-,2-dihydropyrazol-3-one
  • TIMTEC-BB SBB003801
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 3-methyl-1-phenyl-2-pyrazolin-5-on
  • 3-Methyl-1-phenylpyrazol-5-one
  • 3-Methyl-1-phenylpyrazolin-5-one
  • 5-Pyrazolone, 3-methyl-1-phenyl-
  • Developer Z
  • 3-Methyl-1-pehnyl-2-pyrazolin-5-one
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98+%
  • Radicu
  • 3-Methyl-1-phenyl-5-pyrazolido
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • N-demethylantipyrine
  • Radicut
  • 3-Methyl-1-phenylpyrazolin-5(4H)-one
  • 5-Methyl-2-phenyl-1H-pyrazol-3-one
  • MCI-186
  • C.I. Developer 1
  • AURORA KA-3365
  • 2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one
  • 5-METHYL-2-PHENYL-2,4-DIHYDRO-PYRAZOL-3-ONE
  • 2-dihydropyrazol-3-one
  • 5-Methyl-2-phenyl-1
  • 1,3,5- pyrazolone (1- phenyl -3- methyl -5- pyrazolone)
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one, 98%, a strong novel free radical scavenger
  • edaravone-008
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