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Methoxamin

methoxamine Struktur
390-28-3
CAS-Nr.
390-28-3
Bezeichnung:
Methoxamin
Englisch Name:
methoxamine
Synonyma:
Methoxamin;Methoxamedrine;Methoxamine (6CI);Pseudomethoxamine;methoxamine USP/EP/BP;(2S)-Methoxamine oxalate salt;2-Amino-1-(2,5-dimethoxyphenyl)propan-1-ol;a-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol;α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol;α-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol
CBNumber:
CB0882136
Summenformel:
C11H17NO3
Molgewicht:
211.26
MOL-Datei:
390-28-3.mol

Methoxamin Eigenschaften

Schmelzpunkt:
85-86 °C
Siedepunkt:
368.4±42.0 °C(Predicted)
Dichte
1.117±0.06 g/cm3(Predicted)
pka
11.87±0.45(Predicted)

Sicherheit

Methoxamin Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Vasoxyl ,Burroughs-Wellcome,US,1949

Manufacturing Process

2,5-Dimethoxypropiophenone is treated in absolute ether with methyl nitrite and hydrogen chloride. The hydrochloride of 2,5-dimethoxy-αisonitrosopropiophenone crystallizes out of the solution. It is removed, the base is liberated and crystallized from benzene-heptane forming yellow leaflets that melt at about 97° to 98°C. This isonitrosoketone is dissolved in absolute alcohol containing an excess of hydrogen chloride and is hydrogenated with palladized charcoal, yielding β-(2,5-dimethoxyphenyl)-βketoisopropylamine hydrochloride, a salt that melts at about 176°C with decomposition.
12.3 g (1/20 mol) of β-(2,5-dimethoxyphenyl)-β-ketoisopropylamine hydrochloride (MP 176°C) is dissolved in 50 cc of water and hydrogenated with platinum oxide platinum black in the customary Adams-Burgess Parr apparatus. About 1/20 mol of hydrogen is absorbed, after which the solution is filtered off from the catalyst, evaporated to dryness in vacuo and recrystallized from absolute alcohol, absolute ether being added to decrease solubility. The hydrochloride is thus obtained in substantially theoretical yield. It crystallizes in plates and melts at 215°C.

Therapeutic Function

Hypertensive

Methoxamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Methoxamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 21)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30238 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49978 58
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9457 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12335 58
SynAsst Chemical. 021-60343070
China 12740 55
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 17691182729 18161915376
1046@dideu.com China 10001 58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. +86-027-59232304 15387063101
2881924050@qq.com China 9956 58

390-28-3(Methoxamin)Verwandte Suche:


  • Methoxamedrine
  • 2-Amino-1-(2,5-dimethoxyphenyl)propan-1-ol
  • a-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol
  • Benzenemethanol, a-(1-aminoethyl)-2,5-dimethoxy- (9CI)
  • Benzyl alcohol, a-(1-aminoethyl)-2,5-dimethoxy- (8CI)
  • Methoxamine (6CI)
  • Methoxamin
  • α-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol
  • α-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol
  • alpha-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol
  • Benzenemethanol, α-(1-aminoethyl)-2,5-dimethoxy-
  • methoxamine USP/EP/BP
  • (2S)-Methoxamine oxalate salt
  • Pseudomethoxamine
  • 390-28-3
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