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Mexiletin

1-(2,6-Dimethylphenoxy)-2-propanamine Struktur
31828-71-4
CAS-Nr.
31828-71-4
Bezeichnung:
Mexiletin
Englisch Name:
1-(2,6-Dimethylphenoxy)-2-propanamine
Synonyma:
Mexiletine;C07220;MEXILETIN;Mexilitine;Mexiletene;Mexilitine R;dl-Mexiletine;(RS)-Mexiletine;Mexiletine - API;1-Methyl-2-(2,6-xylyloxy)ethylamine
CBNumber:
CB9497353
Summenformel:
C11H17NO
Molgewicht:
179.26
MOL-Datei:
31828-71-4.mol

Mexiletin Eigenschaften

Schmelzpunkt:
203-205 °C
Siedepunkt:
271.5±28.0 °C(Predicted)
Dichte
0.979±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
ethanol: 50 mg/mL
pka
pKa 9.14± 0.01(H2O,t =25±0.2,I=0.01(NaCl))(Approximate)
Aggregatzustand
powder
Farbe
white
BCS Class
1
CAS Datenbank
31828-71-4(CAS DataBase Reference)
NIST chemische Informationen
Mexiletine(31828-71-4)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 20/21/22
S-S?tze: 36
RIDADR  3249
WGK Germany  3
RTECS-Nr. KR9300000
HazardClass  6.1(b)
PackingGroup  III
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Mexiletin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Verwenden

Cardiac depressant (anti-arrhythmic).

Definition

ChEBI: An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.

Clinical Use

Mexiletine (Mexitil) is an antiarrhythmic agent with pharmacological and antiarrhythmic properties similar to those of lidocaine and tocainide. Like tocainide,mexiletine is available for oral administration.
Mexiletine is useful as an antiarrhythmic agent in the management of patients with either acute or chronic ventricular arrhythmias.While it is not at present an indication for use, there is interest in using mexiletine to treat the congenital long QT syndrome when an abnormality in the SCN5A gene (LQTS 3) has been found.

Nebenwirkungen

A very narrow therapeutic window limits mexiletine use. The first signs of toxicity manifest as fine tremor of the hands, followed by dizziness and blurred vision. Hypotension, sinus bradycardia, and widening of the QRS complex have been noted as the most common unwanted cardiovascular effects of IV mexiletine. The side effects of oral maintenance therapy include reversible upper gastrointestinal distress, tremor, lightheadedness, and coordination difficulties. These effects generally are not serious and can be reduced by downward dose adjustment or administering the drug with meals. Cardiovascular adverse effects, which are less common, include palpitations, chest pain, and angina or anginalike pain.

Arzneimittelwechselwirkung

An upward adjustment in dose may be required when mexiletine is administered with phenytoin or rifampin, since these drugs stimulate the hepatic metabolism of mexiletine, reducing its plasma concentration.

Vorsichtsma?nahmen

Mexiletine is contraindicated in the presence of cardiogenic shock or preexisting second- or third-degree heart block in the absence of a cardiac pacemaker. Caution must be exercised in administration of the drug to patients with sinus node dysfunction or disturbances of intraventricular conduction.

Mexiletin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Mexiletin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 62)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32079 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34553 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15354 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24727 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49979 58

31828-71-4(Mexiletin)Verwandte Suche:


  • 1-(2,6-dimethylphenoxy)-2-propanamin
  • 1-methyl-2-(2,6-xylyloxy)-ethylamin
  • 1-Methyl-2-(2,6-xylyloxy)ethylamine
  • 2-Propanamine, 1-(2,6-dimethylphenoxy)-
  • Ethylamine, 1-methyl-2-(2,6-xylyloxy)-
  • Mexilitine
  • 1-(2,6-xylyloxy)-2-aminopropane hydrochloride
  • MEXILETIN
  • (+-)-2-Amino-1-(2',6'-dimethylphenoxy)propane
  • (RS)-Mexiletine
  • 2-Amino-1-(2,6-dimethylphenoxy)propane
  • 2-Propanamine, 1-(2,6-dimethylphenoxy)- (9CI)
  • dl-Mexiletine
  • Ethylamine, 1-methyl-2-(2,6-xylyloxy)- (8CI)
  • Mexiletine (base and/or unspecified salts)
  • 1-(2,6-Dimethylphenoxy)-2-propanamine
  • (2R)-1-(2,6-Dimethylphenoxy)propane-2-amine
  • (R)-1-Methyl-2-(2,6-xylyloxy)ethylamine
  • Mexilitine R
  • (S)-1-Methyl-2-(2,6-xylyloxy)ethylamine
  • 1-(2,6-Dimethylphenoxy)propane-2-amine
  • C07220
  • 1-(2,6-Dimethylphenoxy)-2-propanamine USP/EP/BP
  • Mexiletene
  • Mexiletine
  • Mexiletine - API
  • 31828-71-4
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