Mexiletin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
Cardiac depressant (anti-arrhythmic).
Definition
ChEBI: An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
Clinical Use
Mexiletine (Mexitil) is an antiarrhythmic agent with
pharmacological and antiarrhythmic properties similar
to those of lidocaine and tocainide. Like tocainide,mexiletine
is available for oral administration.
Mexiletine is useful as an antiarrhythmic agent in the
management of patients with either acute or chronic
ventricular arrhythmias.While it is not at present an indication
for use, there is interest in using mexiletine to
treat the congenital long QT syndrome when an abnormality
in the SCN5A gene (LQTS 3) has been found.
Nebenwirkungen
A very narrow therapeutic window limits mexiletine
use. The first signs of toxicity manifest as fine tremor of
the hands, followed by dizziness and blurred vision.
Hypotension, sinus bradycardia, and widening of the
QRS complex have been noted as the most common
unwanted cardiovascular effects of IV mexiletine. The
side effects of oral maintenance therapy include reversible
upper gastrointestinal distress, tremor, lightheadedness,
and coordination difficulties. These effects
generally are not serious and can be reduced by downward
dose adjustment or administering the drug with
meals. Cardiovascular adverse effects, which are less
common, include palpitations, chest pain, and angina or
anginalike pain.
Arzneimittelwechselwirkung
An upward adjustment in dose may be required when
mexiletine is administered with phenytoin or rifampin,
since these drugs stimulate the hepatic metabolism of
mexiletine, reducing its plasma concentration.
Vorsichtsma?nahmen
Mexiletine is contraindicated in the presence of cardiogenic
shock or preexisting second- or third-degree heart
block in the absence of a cardiac pacemaker. Caution
must be exercised in administration of the drug to patients
with sinus node dysfunction or disturbances of intraventricular
conduction.
Mexiletin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2,6-Xylenol
Hydroxylamin
Benzene, 1,3-dimethyl-2-(2-propyn-1-yloxy)-
Carbamic acid, N-[2-(2,6-dimethylphenoxy)-1-methylethyl]-, 1,1-dimethylethyl ester
1-Methyl-2-(2,6-xylyloxy)ethylammoniumchlorid
1-(2,6-DIMETHYLPHENOXY)-2-PROPANOL
1-(2,6-Dimethylphenoxy)aceton
Downstream Produkte