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N,N'-Bis(2-chlorethyl)-nitrosoharnstoff

Carmustine Struktur
154-93-8
CAS-Nr.
154-93-8
Bezeichnung:
N,N'-Bis(2-chlorethyl)-nitrosoharnstoff
Englisch Name:
Carmustine
Synonyma:
BCUN;BCNU;BICNU;fda0345;DTI 015;Gliadel;sri1720;sk27702;BECENUN;nitrumon
CBNumber:
CB0449612
Summenformel:
C5H9Cl2N3O2
Molgewicht:
214.05
MOL-Datei:
154-93-8.mol

N,N'-Bis(2-chlorethyl)-nitrosoharnstoff Eigenschaften

Schmelzpunkt:
30 °C (lit.)
Dichte
1.6948 (rough estimate)
Brechungsindex
1.6100 (estimate)
storage temp. 
-20°C
L?slichkeit
insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH
Aggregatzustand
(Oily liquid to amorphous solid)
pka
10.19±0.46(Predicted)
Farbe
Light-yellow powder
Wasserl?slichkeit
<0.1 g/100 mL at 18 ºC
Merck 
14,1845
Stabilit?t:
Temperature Sensitive
InChIKey
DLGOEMSEDOSKAD-UHFFFAOYSA-N
CAS Datenbank
154-93-8(CAS DataBase Reference)
IARC
2A (Vol. 26, Sup 7) 1987
EPA chemische Informationen
1,3-Bis(2-chloroethyl)-1-nitrosourea (154-93-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T+
R-S?tze: 45-46-60-61-28
S-S?tze: 53-22-36/37/39-45
RIDADR  3249
WGK Germany  3
RTECS-Nr. YS2625000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29241990
Giftige Stoffe Daten 154-93-8(Hazardous Substances Data)
Toxizit?t LD50 in mice (mg/kg): 19-25 orally, 26 i.p., 24 s.c.; in rats (mg/kg): 30-34 orally (Thompson, Larson)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizit?t oral Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
H350 Kann Krebs verursachen. Karzinogenit?t Kategorie 1A Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" />
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

N,N'-Bis(2-chlorethyl)-nitrosoharnstoff Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R45:Kann Krebs erzeugen.
R46:Kann vererbbare Sch?den verursachen.
R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R61:Kann das Kind im Mutterleib sch?digen.
R28:Sehr giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

Chemische Eigenschaften

Carmustine is an orange-yellow crystalline solid or powder.

Verwenden

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

Definition

ChEBI: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.

Allgemeine Beschreibung

Orange-yellow solid.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

Carmustin decomposes rapidly in acid and in solutions above pH 7; most stable in petroleum ether or aqueous solution at pH 4.

Hazard

Extremely toxic, central nervous system depression, pulmonary fibrosis, renal and hepatic damage, cytotoxic, immunosuppressive, carcino- gen.

Brandgefahr

Flash point data for Carmustin are not available. Carmustin is probably combustible.

Sicherheitsprofil

Confirmed carcinogen withexperimental carcinogenic and tumorigenic data. A humanpoison by parenteral route. An experimental poison byingestion, intravenous, intraperitoneal, parenteral, andsubcutaneous routes. Human systemic effects byparenteral, int

m?gliche Exposition

BCNU has been used since 1971 as an antineoplastic agent in the treatment of Hodgkin’slymphoma; multiple meyloma; and primary or metastatic brain tumors. It also has been reported to have antiviral, antibacterial, and antifungal activity, but no evidence was found that it is used in these ways. BCNU is not known to be naturally occurring. Health professionals who handle this drug (for example, pharmacists, nurses, and physicians) may possibly be exposed to BCNU during drug preparation, administration, or cleanup; however, the risks can be avoided through use of containment equipment and proper work practices

Carcinogenicity

Bis(chloroethyl) nitrosourea (BCNU) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

It is generally assumed that BCNU exerts its cytotoxicity through the liberation of alkylating and carbamoylating moieties. An alkylating entity, particularly chloroethyl carbonium ion, is strongly electrophilic and can alkylate a variety of biomolecules, including the purine and pyrimidine bases of DNA. BCNU causes DNA interstrand cross-linking, which is associated with cytotoxicity. The carbamoylation of lysine residues of protein can inactivate certain enzymes, thus interfering with DNA and RNA synthesis and repair processes. The inhibition of glutathione reductase by this carbamoylation further contributes to cytotoxicity.

Versand/Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.

Inkompatibilit?ten

Acids and acid solutions above pH 7 cause rapid decomposition. Most stable at pH 4 in aqueous solution or petroleum ether.

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

N,N'-Bis(2-chlorethyl)-nitrosoharnstoff Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


N,N'-Bis(2-chlorethyl)-nitrosoharnstoff Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 342)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58

154-93-8(N,N'-Bis(2-chlorethyl)-nitrosoharnstoff)Verwandte Suche:


  • Carmustine, >=98%
  • 1,3-BIS(2-CHLOROETHYL)NITROSOUREA
  • 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA
  • DTI 015
  • CarMustine/BCNU
  • Carmustine (75 mg) (COLD SHIPMENT REQUIRED)
  • Carmustinum
  • Gliadel
  • nci-c04773
  • n,n’-bis(2-chloroethyl)-n-nitroso-ure
  • fda0345
  • carmubris
  • bischloroethylnitrosourea
  • bischlorethylnitrosurea
  • 1,3-bis(beta-chloroethyl)-1-nitrosourea
  • NSC-409962
  • N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA
  • sri1720
  • sk27702
  • nitrumon
  • 1,3-bis(2-chloroethyl)-1-nitroso-ure
  • 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU
  • Urea, N,N'-bis(2-chloroethyl)-N'-nitroso-
  • BCNU, N,NBis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun, Bicnu,
  • BCUN
  • CARMUSTINE
  • CARMUSTIN
  • BCNU
  • BECENUN
  • BICNU
  • bis(2-chloroethyl)nitrosourea
  • Carmustine (COLD SHIPMENT REQUIRED) (1096724)
  • Carmustine (BiCNU)
  • Carmustine USP/EP/BP
  • Carmustine >
  • Carmustine, 98%, DNA alkylating agent
  • Carmustine,Bis-chloroethyltrosourea
  • Carmustine[1,3-bis[2-Chloroethyl]-1-nitrosourea
  • Carmustine (75 mg) (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED)
  • Caprylic Acid Impurity 15
  • Camustine
  • 154-93-8
  • C5H9Cl2N3O2
  • BioChemical
  • Apoptosis and Cell Cycle
  • Cell Biology
  • Cell Signaling and Neuroscience
  • DNA metabolism
  • DNA Intercalators and Crosslinkers
  • Pharmaceutical Chemicals
  • SURMONTIL
  • Active Pharmaceutical Ingredients
  • Pharmaceutical Chemicals
  • Mutagenesis Research Chemicals
  • 154-93-8
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