L-DIHYDROOROTIC ACID
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- CAS-Nr.
- 5988-19-2
- Englisch Name:
- L-DIHYDROOROTIC ACID
- Synonyma:
- DNTPS;Dihydroorotic acid;DIHYDRO-L-OROTIC ACID;L-HYDROOROTIC ACID;(S)-Dihydroorotate;(S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid;DI-H-OROTATE;(S)-di-H-orotate;L-4,5-dihydroorotic;L-DIHYDROOROTIC ACID
- CBNumber:
- CB0386533
- Summenformel:
- C5H6N2O4
- Molgewicht:
- 158.11
- MOL-Datei:
- 5988-19-2.mol
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L-DIHYDROOROTIC ACID Eigenschaften
- Schmelzpunkt:
- 254-255 °C (dec.)(lit.)
- Siedepunkt:
- 283.16°C (rough estimate)
- Dichte
- 1.523
- Brechungsindex
- 1.5090 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- DMSO (Slightly), Water (Slightly, Heated, Sonicated)
- pka
- 2.82±0.20(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble in water (partly), and dimethyl formamide.
- InChIKey
- UFIVEPVSAGBUSI-REOHCLBHSA-N
- CAS Datenbank
- 5988-19-2(CAS DataBase Reference)
- NIST chemische Informationen
- Orotic acid, dihydro-, l-(5988-19-2)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36/37/38 |
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| S-S?tze: |
26-36 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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L-DIHYDROOROTIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to off-white crystalline powder
Verwenden
L-Dihydroorotic acid a metabolite.
Biochem/physiol Actions
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
L-DIHYDROOROTIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
L-DIHYDROOROTIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 299)Lieferanten
5988-19-2()Verwandte Suche:
- L-DIHYDROOROTIC ACID
- (S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
- 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
- L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
- (S)-(+)-HYDROOROTIC ACID
- (4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid
- L-4,5-dihydroorotic acid
- (S)-4,5-dihydroorotate
- (S)-4,5-dihydroorotic acid
- (S)-4-pyrimidinecarboxylic acid
- (S)-di-H-orotate
- 4,5-dihydro-L-orotate
- DI-H-OROTATE
- L-4,5-dihydroorotate
- 4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-, (4S)-
- L-4,5-dihydroorotic
- Adenosine-5-triphosphoric acid Na2
- Adenosine-5'-diphosphoric acid Na2
- Deoxyribonucein acid(fish sperm)
- Guanosine-5-diphosphate disodiun
- Guanosine-5-monophosphate disodiun
- Guanosine-5'-triphosphate disodiun
- t-Ribonuclein acid,yeast
- 4-Pyrimidinecarboxylic acid, hexahydro-2,6-dioxo-
- 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid, L-Hydroorotic acid, Dihydro-L-orotic acid
- (4S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid
- (6S)-Hexahydro-2,4-dioxopyrimidine-6β-carboxylic acid
- (S)-Dihydroorotic acid
- Hexahydro-2,6-dioxopyrimidine-4α-carboxylic acid
- Inosine-5-triphosphate trisodium
- Ribonuclein acid,yeast
- Deoxyribonucleoside- 5′-triphosphate
- (4S)-2,6-dioxo-1,3-diazinane-4-carboxylate
- L-5,6-Dihydroorotic acid
- L-DIHYDROOROTIC ACID USP/EP/BP
- (S)-2,6-Dioxohexahydropyrimidine-4-carboxylic acid,L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid,L-Dihydroorotic acid,L-Dihydroorotic Acid
- L-HYDROOROTIC ACID
- DIHYDRO-L-OROTIC ACID
- (S)-Dihydroorotate
- (S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid
- DNTPS
- Dihydroorotic acid
- (S)-dihydrooroticaci
- L-4, 5-dihydrowhey acid
- L-DihydrooroticacidL-Dihydrooroticacid
- Cytidine-5-phosphate disodium salt (CMP)
- Guanosine Phosphate Disodium Salt (GMP)
- 5988-19-2
- BioChemical
- Nucleotide
- Metabolomics
- Metabolites and Cofactors on the Metabolic Pathways Chart
- Metabolic Pathways
- Heterocycles
- Miscellaneous Biochemicals
- Amino Acid Derivatives
- 5988-19-2
