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2'-Desoxyuridin

2'-Deoxyuridine Struktur
951-78-0
CAS-Nr.
951-78-0
Bezeichnung:
2'-Desoxyuridin
Englisch Name:
2'-Deoxyuridine
Synonyma:
DU;deoxyuridine;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;durd;2'-dU;NSC 23615;Uracildeoxyr;Deoxy-uridin;DEOXYURIDINE-2';2'-deoxy-uridin
CBNumber:
CB3472057
Summenformel:
C9H12N2O5
Molgewicht:
228.2
MOL-Datei:
951-78-0.mol

2'-Desoxyuridin Eigenschaften

Schmelzpunkt:
167-169 °C(lit.)
alpha 
D22 +50° (c = 1.1 in N NaOH)
Siedepunkt:
370.01°C (rough estimate)
Dichte
1.3705 (rough estimate)
Brechungsindex
52 ° (C=1, 1mol/L NaOH)
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
Aggregatzustand
Powder
pka
pKa 9.3(H2O t = 25) (Uncertain)
Farbe
White to off-white
Biologische Quelle
synthetic (organic)
Wasserl?slichkeit
300 g/L (20 ºC)
Sensitive 
Air Sensitive
Merck 
14,2910
BRN 
24433
InChIKey
MXHRCPNRJAMMIM-ATRFCDNQSA-N
CAS Datenbank
951-78-0(CAS DataBase Reference)
EPA chemische Informationen
Uridine, 2'-deoxy- (951-78-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 36/37/38
S-S?tze: 22-24/25-37/39-36/37/39-26
WGK Germany  3
RTECS-Nr. YU7490000
F  10-23
Hazard Note  Air Sensitive
TSCA  Yes
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

2'-Desoxyuridin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

2'-Deoxyuridine is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. It has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-Deoxyuridine has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate. It is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses.

Chemische Eigenschaften

White crystalline powder

Verwenden

2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2'-Deoxyuridines used as labeling substrates include chloro-2'-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2'-deoxyuridine include 5-ethynyl-2'-deoxyuridine (DdU) and 5-hydroxymethyl-2'-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Definition

ChEBI: 2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside having uracil as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a uracil.

2'-Desoxyuridin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-CHLORO-2'-DEOXYURIDINE 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-4-(1,2,4-TRIAZOL-1-YL)-5-METHYLPYRIMIDIN-2-ONE 5-(2-HYDROXYETHYL)-2'-DEOXYURIDINE

2'-Desoxyuridin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 564)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhu Nuowei chemistry Co., Ltd. 		+86-0553-2911116-802 +86-18055311600
 sales1@nuowei-chem.com China 1638 58
SHANGHAI NOVRIBO BIOTECH
17821030819
 June.Liu@Desano.com China 73 58
INNOBIO PHARM CO.,LTD
+8615600141006
 cindyyb@126.com China 271 58
Zhengzhou Youmei Medical Technology Co., Ltd.
+8613526582427
 495737714@qq.com China 7 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531153977
 allison@yan-xi.com China 5854 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325
 sales1@chuanghaibio.com China 5868 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365
 mina@chuanghaibio.com China 18137 58
HangZhou RunYan Pharma Technology Co.,LTD. 		+8618882027439
 sales2@runyanpharma.com China 302 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20234 58
airuikechemical co., ltd. 		+86-18353166132 +86-18353166132
 sales02@airuikechemical.com China 983 58

951-78-0(2'-Desoxyuridin)Verwandte Suche:

  • 1-(2'-DEOXY-BETA-D-RIBOFURANOSYL)URACIL
  • 1-(2-DEOXY-BETA-D-RIBOFURANOSYL)URACIL
  • (+)-2'-DEOXYURIDINE
  • DEOXYURIDINE-2'
  • (+)-2'-DEOXYURIDINE, 99+%
  • Uracildeoxyr
  • 1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil
  • NSC 23615
  • 1-(2-deoxy-á-d-ribofuranosyl)uracil
  • 2'-Deoxy-D-uridine
  • 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • 2'-deoxy-uridin
  • 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
  • 1-(2-Deoxy--D-erythro-pentofuranosyl)uracil
  • 1-((2R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
  • 2-DEOXYURIDINE extrapure
  • 1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside
  • 1-(2-Deoxy-β-D-ribofuranosyl)uracil, 2μ-Deoxyuridine, Uracil deoxyriboside
  • Uridine, 2'-deoxy
  • 2'-dU
  • 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione
  • 2'-Deowyuridine
  • 2'-DEOXYURIDINE 99-100%
  • 1-(2-Deoxy-β-D-ribofuranosyl)uracil
  • Deoxy-uridin
  • 1-(2-Deoxy-beta-D-ribofuranosyl)uracil, Uracil deoxyriboside
  • URACIL DEOXYRIBOSIDE
  • 2’-desoxyuridine
  • deoxyriboseuracil
  • durd
  • uracildesoxyuridine
  • 5-Ethynyl-2&rsquo
  • 5-Hydroxymethyl-2&rsquo
  • 2'-Deoxyuridine(2'-dU)
  • 5-(2-Furanyl)-2&rsquo
  • 5-[N(6-(Trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2&rsquo
  • 2'-Deoxyuridine >
  • 2-Deoxyuridine, 1-(beta-D-ribofuranosyl)-4-pyrimidinone
  • 2'-Deoxyuridine USP/EP/BP
  • -deoxyuridine N-Hydroxysuccinimide Ester
  • Cytarabine Impurity 19（2'-Deoxyuridine）
  • (E)-5-(2-Carboxyvinyl)-2&rsquo
  • (E)-5-(2-Carbomethoxyvinyl)-2&rsquo
  • S4-(2-Cyanoethyl)-4-thio-2&rsquo
  • -deoxyuridine-d1
  • DU
  • 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • deoxyuridine
  • (+)-2`-Deoxyuridine
  • 2‘-dU/ 2'-Deoxyuridine
  • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4(1H,3H)-dione (2’-deoxyuridine)
  • 2'-Deoxyuridine, ≥ 98.0%
  • 2'-Deoxyuridine
  • 2''-Deoxyuridine
  • （2‘-dU） 2'-DeoxyUridine
  • 2'-Deoxyuridine-d
  • 2'-Desoxyuridine
  • Brovudine impurity 4
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