2'-Desoxyuridin
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- CAS-Nr.
- 951-78-0
- Bezeichnung:
- 2'-Desoxyuridin
- Englisch Name:
- 2'-Deoxyuridine
- Synonyma:
- DU;deoxyuridine;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;durd;2'-dU;NSC 23615;Uracildeoxyr;Deoxy-uridin;DEOXYURIDINE-2';2'-deoxy-uridin
- CBNumber:
- CB3472057
- Summenformel:
- C9H12N2O5
- Molgewicht:
- 228.2
- MOL-Datei:
- 951-78-0.mol
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2'-Desoxyuridin Eigenschaften
- Schmelzpunkt:
- 167-169 °C(lit.)
- alpha
- D22 +50° (c = 1.1 in N NaOH)
- Siedepunkt:
- 370.01°C (rough estimate)
- Dichte
- 1.3705 (rough estimate)
- Brechungsindex
- 52 ° (C=1, 1mol/L NaOH)
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
- Aggregatzustand
- Powder
- pka
- pKa 9.3(H2O
t = 25) (Uncertain)
- Farbe
- White to off-white
- Biologische Quelle
- synthetic (organic)
- Wasserl?slichkeit
- 300 g/L (20 ºC)
- Sensitive
- Air Sensitive
- Merck
- 14,2910
- BRN
- 24433
- InChIKey
- MXHRCPNRJAMMIM-ATRFCDNQSA-N
- CAS Datenbank
- 951-78-0(CAS DataBase Reference)
- EPA chemische Informationen
- Uridine, 2'-deoxy- (951-78-0)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2'-Desoxyuridin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2'-Deoxyuridine is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. It has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-Deoxyuridine has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate. It is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses.
Chemische Eigenschaften
White crystalline powder
Verwenden
2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2'-Deoxyuridines used as labeling substrates include chloro-2'-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2'-deoxyuridine include 5-ethynyl-2'-deoxyuridine (DdU) and 5-hydroxymethyl-2'-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.
Definition
ChEBI: 2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside having uracil as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a uracil.
2'-Desoxyuridin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2'-Desoxyuridin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 564)Lieferanten
951-78-0(2'-Desoxyuridin)Verwandte Suche:
6-Methyluracil
Uridine
Cytidin
1-β-D-Arabinofuranosyl-(1H,3H)-pyrimidin-2,4-dion
Uracil
3-α,12-α-Dihydroxy-5-β-cholan-24-sure
2'-Desoxyguanosin-5'-(dinatriumphosphat)
5'-Thymidylsure, Dinatriumsalz
5'-Uridylsure, 2'-Deoxy-, Dinatriumsalz
DNA polymeraseⅠfrom E.coli
5-Brom-2'-deoxyuridin
[3β(2R,3R),4α,6α,7α,15α(R),16β]-4,9-Epoxycevan-3,4,6,7,14,15,16,20-octol-6,7-diacetat-3-(2,3-dihydroxy-2-methylbutyrat)-15-(2-methylbutyrat)
Doxifluridin
DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS*
BrdU (Bromodeoxyuridine)
5-Fluor-2'-desoxyuridin
5-Methyluridin
Trifluridin
- 1-(2'-DEOXY-BETA-D-RIBOFURANOSYL)URACIL
- 1-(2-DEOXY-BETA-D-RIBOFURANOSYL)URACIL
- (+)-2'-DEOXYURIDINE
- DEOXYURIDINE-2'
- (+)-2'-DEOXYURIDINE, 99+%
- Uracildeoxyr
- 1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil
- NSC 23615
- 1-(2-deoxy-á-d-ribofuranosyl)uracil
- 2'-Deoxy-D-uridine
- 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- 2'-deoxy-uridin
- 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
- 1-(2-Deoxy--D-erythro-pentofuranosyl)uracil
- 1-((2R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
- 2-DEOXYURIDINE extrapure
- 1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside
- 1-(2-Deoxy-β-D-ribofuranosyl)uracil, 2μ-Deoxyuridine, Uracil deoxyriboside
- Uridine, 2'-deoxy
- 2'-dU
- 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione
- 2'-Deowyuridine
- 2'-DEOXYURIDINE 99-100%
- 1-(2-Deoxy-β-D-ribofuranosyl)uracil
- Deoxy-uridin
- 1-(2-Deoxy-beta-D-ribofuranosyl)uracil, Uracil deoxyriboside
- URACIL DEOXYRIBOSIDE
- 2’-desoxyuridine
- deoxyriboseuracil
- durd
- uracildesoxyuridine
- 5-Ethynyl-2&rsquo
- 5-Hydroxymethyl-2&rsquo
- 2'-Deoxyuridine(2'-dU)
- 5-(2-Furanyl)-2&rsquo
- 5-[N(6-(Trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2&rsquo
- 2'-Deoxyuridine >
- 2-Deoxyuridine, 1-(beta-D-ribofuranosyl)-4-pyrimidinone
- 2'-Deoxyuridine USP/EP/BP
- -deoxyuridine N-Hydroxysuccinimide Ester
- Cytarabine Impurity 19(2'-Deoxyuridine)
- (E)-5-(2-Carboxyvinyl)-2&rsquo
- (E)-5-(2-Carbomethoxyvinyl)-2&rsquo
- S4-(2-Cyanoethyl)-4-thio-2&rsquo
- -deoxyuridine-d1
- DU
- 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
- deoxyuridine
- (+)-2`-Deoxyuridine
- 2‘-dU/ 2'-Deoxyuridine
- 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4(1H,3H)-dione (2’-deoxyuridine)
- 2'-Deoxyuridine, ≥ 98.0%
- 2'-Deoxyuridine
- 2''-Deoxyuridine
- (2‘-dU) 2'-DeoxyUridine
- 2'-Deoxyuridine-d
- 2'-Desoxyuridine
- Brovudine impurity 4