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2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon

Phlorizin Struktur
60-81-1
CAS-Nr.
60-81-1
Bezeichnung:
2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon
Englisch Name:
Phlorizin
Synonyma:
NSC 2833;Floridzin;PHLORIZIN;Phlorinin;phlorhizin;phlorizine;PHLORIDZIN;phloridzine;phlorrhizin;Phlorrhizen
CBNumber:
CB0331801
Summenformel:
C21H24O10
Molgewicht:
436.41
MOL-Datei:
60-81-1.mol

2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Eigenschaften

Schmelzpunkt:
113-114 °C(lit.)
Siedepunkt:
468.89°C (rough estimate)
Dichte
1.3178 (rough estimate)
Brechungsindex
-54 ° (C=3.2, 95% EtOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
7.15±0.40(Predicted)
Farbe
Light Yellow to Tan
Merck 
14,7327
InChIKey
IOUVKUPGCMBWBT-LKLLPNDVNA-N
SMILES
C(C1C(=CC(O)=CC=1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O)(=O)CCC1C=CC(O)=CC=1 |&1:9,10,11,13,15,r|
LogP
0.452 (est)
CAS Datenbank
60-81-1(CAS DataBase Reference)
EPA chemische Informationen
Phlorizin (60-81-1)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  3
RTECS-Nr. UC2080000
3-10-23
HS Code  29389090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Light Yellow Powder

Verwenden

Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes. Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2. It competitively inhibits the initial rate of a-methyl-D-glucopyranoside (a-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively. In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.

Definition

ChEBI: An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage.

l?uterung methode

-D-glucoside] [60-81-1] M 472.5, m 110o, [] 20 -62o (c 3.2, EtOH). Phlorizin crystallises as the dihydrate from water and causes glycosuria. [Brazy & Dennis Am J Physiol 234 1279 1978, Zemplen & Bognár Chem Ber 17B 1040 1943, Beilstein 17/7 V 177.]

2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 340)Lieferanten
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Shaanxi LonierHerb Bio Technology Co Ltd
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18017610038
zheyansh@163.com CHINA 3619 58

60-81-1(2'-(beta-D-Glucopyranosyloxy)-4,'6'-dihydroxy-3-(4-hydroxyphe-nyl)propiophenon)Verwandte Suche:


  • 1-propanone,1-(2-(beta-d-glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyp
  • phlorhizin
  • phloridzine
  • phlorizine
  • phlorizoside
  • 1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-
  • 4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
  • Floridzin
  • 1-(2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propan-1-on
  • phlorrhizin
  • TIMTEC-BB SBB005924
  • PHLORIZIN HYDRATE
  • PHLORETIN-2'-BETA-D-GLUCOPYRANOSIDE DIHYDRATE
  • PHLORETIN-2'-BETA-D-GLUCOSIDE
  • PHLORETIN 2'-BETA-D-GLUCOSIDE DIHYDRATE
  • PHLORETIN-2'-O-GLUCOSIDE DIHYDRATE
  • PHLORIDZIN
  • PHLORIDZIN DIHYDRATE
  • PHLORIZIN
  • 4',6'-DIHYDROXY-2'-(BETA-D-GLUCOSIDO)-3-(4-HYDROXYPHENYL) PROPIOPHENONE
  • 1-[2-(BETA-D-GLUCOPYRANOSYLOXY)-4,6-DIHYDROXYPHENYL]-3-(4-HYDROXYPHENYL)-1-PROPANONE
  • 2'-O-GLUCOSYL-4',6',4-TRIHYDROXYDIHYDROCHALCONE
  • 2'-O-GLUCOSYL-4',6',4-TRIHYDROXYDIHYDROCHALCONE DIHYDRATE
  • 2'-(beta-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
  • 1-[2-(b-D-Glucopyranosyl-oxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
  • Phloretin-2b-glucosid
  • Phlorrhizen
  • 1-(2-(beta-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl)-3-(4-hydroxyphenyl)-propan-1-on
  • phloridzosid
  • PHLORIDZIN(P)
  • 1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one
  • Phlorizin(Phloridzin)
  • 1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
  • Phlorizin 60-81-1
  • Phloridzin n-Hydrate, from Apple
  • NSC 2833
  • Phlorizin,>98%
  • Phlorinin
  • hot selling phloridzin
  • Phlorizin (Floridzin
  • 2'-(beta-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyph...
  • 1-Propanone,1-[2-(b-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
  • 1-(2,4-Dihydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-3-(4-hydroxyphenyl)propan-1-one
  • Phloretin 2'-O-β-D-glucoside
  • Apple Root Extract Phlorizin
  • Floridzin|||NSC 2833|||Phloridzin
  • Allyl Amyl Glycolate,Isogalbanate
  • Phloridzin-RM
  • 60-81-1
  • C21H24O10xH2O
  • C21H24O10
  • C21H24O10H2O
  • Glycosides
  • Sugars
  • Analytical Chromatography Product Catalog
  • BioChemical
  • Biochemicals and Reagents
  • Analytical Standards
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