FidaxoMicin
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- CAS-Nr.
- 873857-62-6
- Englisch Name:
- FidaxoMicin
- Synonyma:
- Fidaxomicin Crystalline;Dificid;OPT-80;CS-741;PAR-101;fedamycin;Fentanycin;FidaxoMicin;Fidaxomycin;FidaxoMicinr
- CBNumber:
- CB02582922
- Summenformel:
- C52H74Cl2O18
- Molgewicht:
- 1058.04
- MOL-Datei:
- 873857-62-6.mol
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FidaxoMicin Eigenschaften
- Schmelzpunkt:
- 161 °C
- Siedepunkt:
- 1046.4±65.0 °C(Predicted)
- Dichte
- 1.33
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly)
- Aggregatzustand
- powder
- pka
- 5.09±0.35(Predicted)
- Farbe
- White to Off-White
FidaxoMicin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Fidaxomicin (OPT-80) was approved by the U.S. FDA in May 2011 for
the treatment of Clostridium difficile-associated diarrhea (CDAD), joining
metronidazole and vancomycin as drugs recommended for treatment of
C. difficile infections (CDI). Fidaxomicin, also known as
lipiarmycin and tiacumicin, is an 18-membered macrolide natural
product that was first reported in mid-1970s and is produced by
fermentation. Fidaxomicin and its primary metabolite OP-1118,
which results from hydrolysis of the isobutyryl ester, are narrowspectrum
antibacterial agents with activity against gram-positive aerobic
and anaerobic organisms, but not against gram-negative organisms.
Fidaxomicin and OP-1118 exert their antibacterial activity by inhibiting
bacterial RNA polymerase, thereby inhibiting bacterial protein
synthesis.
The MIC90 (minimum inhibitory concentration to kill 90% of
bacteria) for fidaxomicin against C.difficile is 0.125–0.25 μg/mL; OP-
1118 is 4- to 16-fold less potent than the parent compound.
Fidaxomicin has been reported to spare native intestinal flora such as
Bacteroides spp. and as such, may prevent selection of drug-resistant
bacteria. Fidaxomicin is bactericidal to C. difficile and has a low
propensity for resistance development with no cross-resistance to
existing antibiotics. Fidaxomicin shows minimal systemic absorption following oral administration in preclinical studies and humans.
Verwenden
Fidaxomicin is a recently marketed antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones, isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic with excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.
Definition
ChEBI: An 18-membered macrolide that is a fermentation product obtained from the Actinomycete Dactylosporangium aurantiacum. A narrow spectrum antibiotic used for treatment of Clostridium difficile-related infections.
Pharmazeutische Anwendungen
Formerly known as difimicin. An 18-membered macrocyclic
compound related to the tiacumicin group of antibiotics
rather than conventional macrolides. It is active against
staphylococci (MIC 0.5–2 mg/L) and most anaerobic Grampositive
bacilli and cocci, but Gram-negative bacilli, including
Gram-negative anaerobes, are resistant. It is very poorly
absorbed when given orally and most interest surrounds its
activity against C. difficile (MIC 0.12–0.25 mg/L). Such data
as are presently available from clinical trials suggest that it is
as safe and effective in the treatment of C. difficile-associated
diarrhea as vancomycin.
FidaxoMicin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
FidaxoMicin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 275)Lieferanten
873857-62-6()Verwandte Suche:
- FidaxoMicin
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one
- OPT-80
- PAR-101
- R-Tiacumicin B
- Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,9E,11S,12R,13E,15E,18S)-
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-eth
- Fidaxomicin
R-Tiacumicin B
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-b-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-b-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydro
- Fidaxomycin
- Fidaxomicin, >=98%
- FidaxoMicin(LipiarMycin)
- ClostoMicin B1, LipiarMycin A3, TiacuMicin B, OPT 80
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxy
- 3-(((6-Deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl)oxy)-methyl)-12(R)-[(6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl)oxy]-11(S)-ethyl-8(S)-hydroxy-18(S)-(1(R)-hydroxyethyl)-9,13,15-trimethyloxacyclooctadeca-3,5,9,13,15-pentaene-2-one
- Fidaxomicin (OPT-80)
- Clostomicin B1
- OPT-80;PAR-101;CLOSTOMICIN B1;TIACUMICIN B
- CS-741
- fidaxomicin,Dificid
- Oxacyclooctadeca-3,5,9,13,15-pentaen-2-one, 3-[[[6-deoxy-4-O-(3,5-dichloro-2-ethyl-4,6-dihydroxybenzoyl)-2-O-methyl-β-D-mannopyranosyl]oxy]methyl]-12-[[6-deoxy-5-C-methyl-4-O-(2-methyl-1-oxopropyl)-β-D-lyxo-hexopyranosyl]oxy]-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-, (3E,5E,8S,...
- Lipiarmycin A3
- FidaxoMicin USP/EP/BP
- FidaxoMicinr
- US-DMF No.: 028803
- FidaxomicinQ: What is
Fidaxomicin Q: What is the CAS Number of
Fidaxomicin Q: What is the storage condition of
Fidaxomicin Q: What are the applications of
Fidaxomicin
- Fidaxomicin D7Q: What is
Fidaxomicin D7 Q: What is the CAS Number of
Fidaxomicin D7 Q: What is the storage condition of
Fidaxomicin D7 Q: What are the applications of
Fidaxomicin D7
- Dificid
- Not for drug
- Fidaxomicin Crystalline
- (2R,3S,4S,5S,6R)-6-(((3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-(((2R,3S,4R,5S)-3,4-Dihydroxy-5-(isobutyryloxy)-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-11-ethyl-8-hydroxy-18-((R)-1-hydroxyethyl)-9,13,15-trimethyl-2-oxooxacyclooctadeca-3,5,9,13,15-pentaen-3-yl)methoxy)-4-hydroxy-5-methoxy-2-methyltetrahydro-2H-pyran-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate
- fedamycin
- Fentanycin
- 873857-62-6
- 52H74Cl2O18
- C52H74Cl2O18
- Fidaxomicin and Impurities
- http://www.bocsci.com/fidaxomicin-cas-873857-62-6-item-471588.html
- Antibiotic
- APIs
- Inhibitor
- Inhibitors
- SiChem
