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Spiramycin

Spiramycin Struktur
8025-81-8
CAS-Nr.
8025-81-8
Bezeichnung:
Spiramycin
Englisch Name:
Spiramycin
Synonyma:
LEUCOMYCIN;espiramicin;Spiramycine;Spiramycin Ep;KITASAMYCIN BASE;5337r.p.;r.p.5337;rovamycin;nsc-64393;provamycin
CBNumber:
CB0396400
Summenformel:
C43H74N2O14
Molgewicht:
843.05
MOL-Datei:
8025-81-8.mol

Spiramycin Eigenschaften

Schmelzpunkt:
126-128 °C
Siedepunkt:
914℃
alpha 
D20 -80° (methanol)
Brechungsindex
81 ° (C=2, 10% AcOH)
Flammpunkt:
>110°(230°F)
storage temp. 
2-8°C
L?slichkeit
ethanol: 50 mg/mL, clear to slightly hazy, light-yellow
Aggregatzustand
powder
Farbe
white to light yellow
Optische Aktivit?t
[α]/D -85 to -80° in water (Specific rotation (dry basis))
Wasserl?slichkeit
Soluble in methanol. Slightly soluble in water
Merck 
14,8752
CAS Datenbank
8025-81-8
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36-24/25
WGK Germany  1
RTECS-Nr. WG9400000
10
HS Code  29419090
Giftige Stoffe Daten 8025-81-8(Hazardous Substances Data)
Toxizit?t LD50 in rats (mg/kg): 9400 orally; 1000 s.c.; 170 i.v. (Sous)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
Sicherheit
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P403 An einem gut belüfteten Ort aufbewahren.

Spiramycin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Spiramycin was found in the culture broth of Streptomyces ambofaciens by Rhone Poulenc in 1954 and its acetate was synthesized by Kyowa Hakko Kogyo Co. in 1965. This antibiotic consists of three closely related macrolide components, I, II, and III, whose ratio is 2 : 1 : 1. Spiramycin shows almost the same antimicrobial spectrum and activity as the other macrolides, but its acetate, acetylspiramycin, has much better pharmacokinetic properties and activity in vivo.

Chemische Eigenschaften

An antibiotic substance.

Verwenden

Spiramycin I (foromacidin A) is the major analogue of a complex of 16-membered macrocyclic lactones produced by S. ambofaciens and S. spiramyceticus that have broad spectrum antibiotic activity. Spiramycins are unusual among the macrocyclic lactones in that they contain two basic sugars. Spiramycin complex has been used in both human and animal health but its use has not been widespread.

Antimicrobial activity

Enterobacteriaceae are resistant. Spiramycin is also active against anaerobic species: Actinomyces israelii (MIC 2–4 mg/L), Cl. perfringens (MIC 2–8 mg/L) and Bacteroides spp. (MIC 4–14 mg/L). It is also active against Tox. gondii.

Hazard

Poison; moderately toxic; teratogen; muta- gen; can cause hypermotility, diarrhea, nausea, or vomiting.

Pharmazeutische Anwendungen

A fermentation product of Streptomyces ambofaciens, composed of several closely related compounds. Spiramycin 1 is the major component (c. 63%); spiramycins 2 and 3 are the acetate and monopropionate esters, respectively. It is available for oral administration and as spiramycin adipate for intravenous infusion. Spiramycins are relatively stable in acid conditions. A derivative, acetylspiramycin, is available in Japan.

Pharmakokinetik

Oral absorption: Variable
Cmax 1 g oral: 2.8 mg/L after 2 h
Plasma half-life:4–8h
Volume of distribution :383 L
Plasma protein binding :15%
In healthy volunteers given 2 g orally followed by 1 g every 6 h, peak plasma levels were 1.0–6.7 mg/L. After 1 g orally the AUC was 10.8 mg.h/L, with an apparent elimination halflife of 2.8 h. It is widely distributed in the tissues. It does not reach the CSF. Levels 12 h after a dose of 1 g were 0.25 mg/L in serum, 5.3 mg/L in bone and 6.9 mg/L in pus. Levels of 10.6 mg/L have been found 4 h after dosing in saliva, and concentrations at least equal to those in the serum are seen in bronchial secretions. A concentration of 27 mg/g was found in prostate tissues after repeated dosage. Only 5–15% is recovered from the urine. Most is metabolized, but significant quantities are eliminated via the bile, in which concentrations up to 40 times those in the serum may be found.

Nebenwirkungen

Spiramycin is generally well tolerated, the most common adverse reactions being gastrointestinal disturbances, notably abdominal pain, nausea and vomiting, rashes and sensitization following contact.

Spiramycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Spiramycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 367)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Wuhan Fortuna Chemical Co., Ltd
+86-027-59207850
info@fortunachem.com China 5986 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18232 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410
sales@ichemie.com China 998 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58

8025-81-8(Spiramycin)Verwandte Suche:


  • SPIRAMYCIN
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  • provamycin
  • FORMACIDINE
  • foromacidin
  • sequamycin
  • spiramycin from streptomyces sp.
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  • SPIRAMYCIN VETRANAL, 100 MG
  • SpiramycinBaseEp97
  • 2-[12-[5-(4,5-Dihydroxy-4,6-dimethyl-oxan-2-yl)oxy-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-8-(5-dimethylamino-6-methyl-oxan-2-yl)oxy-14-hydroxy-13-methoxy-2,9-dimethyl-16-oxo-1-oxacyclohexadeca-4,6-dien-11-yl]acetaldehyde
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  • SpiraMycin(SpiraMycin base)
  • SpiraMycin 0.1
  • foromacidine
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  • antibiotic799
  • nsc-64393
  • r.p.5337
  • rovamycine
  • 2-[(4R,6S,7R,9R,10R,11E,13E,16R)-6-[[5-[(4,5-dihydroxy-4,6-dimethyl-2-oxanyl)oxy]-4-(dimethylamino)-3-hydroxy-6-methyl-2-oxanyl]oxy]-10-[[5-(dimethylamino)-6-methyl-2-oxanyl]oxy]-4-hydroxy-5-methoxy-9
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  • LEUCOMYCIN
  • KITASAMYCIN BASE
  • Spiramycine
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  • Dopamine Impurity 60
  • Spiramycin in methanol
  • C16972900 Spiramycin
  • Spiramycin 100 μg/ml Methanol
  • Spiramycin in Acetonitrile
  • 8025-81-8
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  • C43H74N2O14
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