Spectinomycindihydrochlorid
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- CAS-Nr.
- 21736-83-4
- Bezeichnung:
- Spectinomycindihydrochlorid
- Englisch Name:
- SPECTINOMYCIN DIHYDROCHLORIDE
- Synonyma:
- SPECTINOMYCIN HYDROCHLORIDE;M 141;stanilo;U-18409AE;NSC 248616;Spectacomycin;SPECTINOMYCIN 2HCL;SPECTINOMYCIN DIHYDROC;Spectinomycin (50mg/ml);Methomycin hydrochloride
- CBNumber:
- CB3690961
- Summenformel:
- C14H25ClN2O7
- Molgewicht:
- 368.81
- MOL-Datei:
- 21736-83-4.mol
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Spectinomycindihydrochlorid Eigenschaften
- Schmelzpunkt:
- 194°C
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- H2O: 50 mg/mL, clear, faintly yellow
- Aggregatzustand
- powder
- Farbe
- White to Off-White
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
2 |
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| RTECS-Nr. |
WG7400000 |
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| F |
10 |
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| Toxizit?t |
monkey,LD50,oral,500mg/kg (500mg/kg),Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 7, Pg. 100, 1965. |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P285 |
Bei unzureichender Belüftung Atemschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P304+P341 |
BEI EINATMEN: Bei Atembeschwerden an die frische Luft bringen und in einer Position
ruhigstellen, die das Atmen erleichtert |
| P321 |
Besondere Behandlung |
| P333+P313 |
Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P342+P311 |
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Spectinomycindihydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
SPECTINOMYCIN DIHYDROCHLORIDE is White Powder
Verwenden
SPECTINOMYCIN DIHYDROCHLORIDE is an antibiotic used in the treatment and control of infectious bacterial enteritis in animals. Used in drug testing against nonreplicating mycobacterium tuberculosis.
Definition
SPECTINOMYCIN DIHYDROCHLORIDE is a hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.
Clinical Use
The aminocyclitol antibiotic spectinomycin hydrochloride(Trobicin), isolated from Streptomyces spectabilis andonce called actinospectocin, was first described by Lewisand Clapp. Its structure and absolute stereochemistryhave been confirmed by x-ray crystallography. It occursas the white, crystalline dihydrochloride pentahydrate,which is stable in the dry form and very soluble in water.Solutions of spectinomycin, a hemiacetal, slowly hydrolyzeon standing and should be prepared freshly andused within 24 hours. It is administered by deep intramuscularinjection.
Spectinomycin is a broad-spectrum antibiotic withmoderate activity against many Gram-positive and Gramnegativebacteria. It differs from streptomycin and thestreptamine-containing aminoglycosides in chemical and antibacterialproperties. Like streptomycin, spectinomycininterferes with the binding of transfer RNA (tRNA) to the ribosomesand thus with the initiation of protein synthesis.Unlike streptomycin or the streptamine-containing antibiotics,however, it does not cause misreading of the messenger.Spectinomycin exerts a bacteriostatic action and isinferior to other aminoglycosides for most systemic infections.Currently, it is recommended as an alternative to penicillinG salts for the treatment of uncomplicated gonorrhea.A cure rate of more than 90% has been observed in clinicalstudies for this indication. Many physicians prefer to use atetracycline or erythromycin for prevention or treatment ofsuspected gonorrhea in penicillin-sensitive patients because,unlike these agents, spectinomycin is ineffective againstsyphilis. Furthermore, it is considerably more expensive thanerythromycin and most of the tetracyclines.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx and HCl.
l?uterung methode
The salt is purified by recrystallisation from aqueous Me2CO and is soluble in H2O, MeOH and dilute acid and base, but only slightly soluble in Me2CO, EtOH, CHCl3 and *C6H6. The free base is an amorphous solid, m 184-194o with []D -20o (H2O). [Wiley et al. J Am Chem Soc 93 2652 1963, X-ray: Cochran et al. J Chem Soc Chem Commun 494 1972.] It is an aminoglycoside antibiotic which interacts with 16S ribosomal RNA [Moazet & Noller Nature 327 389 1987] and is used for the treatment of gonorrhea [Rinehart J Infect Dis 119 345 1969].
Spectinomycindihydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Carbamic acid, [4-(acetyloxy)decahydro-4a,7,9-trihydroxy-2-methyl-2H-pyrano[2,3-b][1,4]benzodioxin-6,8-diyl]bis[methyl-, bis(phenylmethyl) ester, [2R-(2α,4β,4aβ,5aβ,6α,7α,8α,9β,9aβ,10aβ)]- (9CI)
Downstream Produkte
Spectinomycindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 286)Lieferanten
21736-83-4(Spectinomycindihydrochlorid)Verwandte Suche:
Hydralazinhydrochlorid
5,6-Dihydro-2-(2,6-xylidino)-4H-1,3-thiazinmonohydrochlorid
Metacyclinhydrochlorid
Betazoldihydrochlorid
Phenylhydraziniumchlorid
Tetracyclin
Metronidazol
Lineomycin Hydrochloride
Doxycyclin
5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, Dinatriumsalz, [6R-[6α,7β(Z)]]-
Amoxicillin
Norfloxacin
Ribostamycinsulfat
Spectinomycin
Spectinomycindihydrochlorid
- 8-beta,9-alpha,9a-alpha,10a-beta))-t
- 8-bis(methylamino)-,dihydrochloride,(2r-(2-alpha,4a-beta,5a-beta,6-beta,7-be
- (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one Hydrochloride
- SpectinoMycinHydrochloride for Injection
- 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-Methyl-6,8-bis(MethylaMino)-, hydrochloride(1:2), (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-
- (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one, hydrochloride (1:2)
- U-18409AE
- SPECTINOMYCIN DIHYDROCHLORIDE
- SPECTINOMYCIN 2HCL
- ACTINOSPECTACIN DIHYDROCHLORIDE
- stanilo
- SPECTINOMYCIN READY MADE SOLUTION
- Spectinomycin2HClpentahydrate
- SPECTINOMYCINHYDROCHLORIDEANHYDROUS
- 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- (9CI)
- 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, dihydrochloride, [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]- (8CI)
- NSC 248616
- M 141
- Raw Material Spectinomycin Dihydrochloride / Spectinomycin HCL CAS 21736-83-4
- Spectinomycin dihydrochloride, >98%
- SPECTINOMYCIN DIHYDROC
- Spectinomycin Hydrochloride and Lincomycin Hydrochloride Soluble Powder
- SPECTINOMYCIN DIHYDROCHLORIDE USP/EP/BP
- (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-benzo[b]pyrano[2,3-e][1,4]dioxin-4-one dihydrochloride
- SPECTINOMYCIN HYDROCHLORIDE
- Methanomycin hydrochloride
- Spectinomycin (50mg/ml)
- Spectacomycin
- (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)octahydro-2H-benzo[b]pyrano[2,3-e][1,4]dioxin-4(3H)-one hydrochloride
- Methomycin hydrochloride
- SPECTINOMYCIN DIHYDROCHLORIDEv
- Gentamicin hydrochloride
- 21736-83-4
- 21736-83-5
- C14H26Cl2N2O7
- C14H24N2O72ClH
- C14H24N2O7HClH2O
- C14H25ClN2O7
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