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9050-30-0

中文名稱 硫酸類肝素
英文名稱 Heparitin, sulfate
CAS 9050-30-0
分子式 C14H23NO21S3
更新日期 2024/12/17 15:32:15
9050-30-0 結(jié)構(gòu)式 9050-30-0 結(jié)構(gòu)式

基本信息

中文別名
硫酸類肝素
硫酸乙酰肝素
英文別名
C00925
Tavidan
Heparitin
Alpha-Idosane
Heparan, sulfate
Heparatan sulfate
Heparan N-sulfate
Heparitin monosulfate
N-Acetylheparan sulfate
Duodenum Heparinoid USP/EP/BP
所屬類別
生物化工:多糖

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度可溶于酸性水溶液(輕微)、水(輕微)
形態(tài)固體
顏色白色至灰白色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H332-H302-H317

常見問題列表

用途

硫酸類肝素是一種復(fù)雜的線性多糖。它作為硫酸乙酰肝素蛋白聚糖的一部分出現(xiàn),在細(xì)胞表面和細(xì)胞外基質(zhì)中表達(dá)豐富。

生物活性
Heparan sulfate是一種復(fù)雜的線性多糖。它作為硫酸乙酰肝素蛋白聚糖的一部分出現(xiàn),在細(xì)胞表面和細(xì)胞外基質(zhì)中表達(dá)豐富。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

Heparan sulfate is a linear polysaccharide and belongs to the family of glycosaminoglycans. Heparan sulfate is composed of glucuronic acid (GlcA) and iduronic acid (IdoA) residues as well as N-acetyl glucosamines (GlcNAc) with various sulfation modifications, and is typically 50-200 disaccharides in length. Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to maintenance of morphogen gradients and co-receptor functions. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.

體內(nèi)研究

Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning. FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate.

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