89750-14-1
中文名稱
glucagon-like peptide 1
英文名稱
glucagon-like peptide 1
CAS
89750-14-1
分子式
C149H226N40O45
分子量
3297.63
MOL 文件
89750-14-1.mol
更新日期
2025/01/26 14:20:38
89750-14-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
序列H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
應(yīng)用領(lǐng)域
用途一
GLP-1 stimulates pancreatic β cells to secrete insulin as
an incretin hormone. GLP-1 also has additional actions,
including suppression of glucagon secretion, inhibition of
gastric motility, and promotion of satiety. GLP-1 was first identified in the early 1980s, following
the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the
N-terminal extended forms of GLP-1(1–37 and 1–36
amide). However, these forms were devoid of biological
activity. In the late 1980s, bioactive GLP-1 peptides were
purified from gut extracts and were identified to be GLP-1(7–37) and GLP-1(7–36)-amide. In the current literature,
the unqualified designation of GLP-1 corresponds to the
truncated peptides.