878978-76-8
878978-76-8 結(jié)構(gòu)式
基本信息
中文別名
化合物ML-098GTP結(jié)合蛋白RAB7激活劑(ML-098)
英文別名
ML-809ML-098
CS-1456
CID7345532
CID 7345532
CID-7345532
ML098
ML 098
CID-7345532
CID 7345532
CID7345532
ML 098
ML098
1-[2-(2,5-dimethylphenoxy)ethyl]-1h-indole-3-carboxylic Acid
1H-Indole-3-carboxylic acid, 1-[2-(2,5-dimethylphenoxy)ethyl]-
所屬類別
生物化工：激動劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)535.5±45.0 °C(Predicted)
密度1.17±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO:53.0(Max Conc. mg/mL);171.45(Max Conc. mM)
酸度系數(shù)(pKa)3.93±0.10(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見問題列表
生物活性
ML-098（CID-7345532）是GTP結(jié)合蛋白Rab7的激活劑，EC50值為77.6nM。靶點(diǎn)
EC50: 77.6 nM (Rab7)
體外研究
Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC 50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).