1417700-13-0
中文名稱
ML188
英文名稱
ML188
CAS
1417700-13-0
分子式
C26H31N3O3
分子量
433.54
MOL 文件
1417700-13-0.mol
更新日期
2023/03/20 15:41:21
1417700-13-0 結(jié)構(gòu)式
基本信息
中文別名
(R)-N-(4-(叔丁基)苯基)-N-(2-(叔丁基氨基)-2-氧代-1-(吡啶-3-基)乙基)呋喃-2-甲酰胺 英文別名
ML188(R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide
3-Pyridineacetamide, N-(1,1-dimethylethyl)-α-[[4-(1,1-dimethylethyl)phenyl](2-furanylcarbonyl)amino]-, (αR)-
物理化學(xué)性質(zhì)
沸點(diǎn)630.7±55.0 °C(Predicted)
密度1.142±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO: 250 mg/mL (576.65 mM)
酸度系數(shù)(pKa)14.24±0.46(Predicted)
形態(tài)固體
顏色白色至灰白色
常見問題列表
生物活性
ML188，一種探針，也是一種選擇性非共價(jià) SARS-CoV 3CLpro 抑制劑， IC50 為 1.5 μM。具有抗病毒活性。體外研究
ML188 (0-30 μM; 48 hours) effectively inhibit SARS-CoV replication in cell culture.
Probe ML188 is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action. ML188 yields an antiviral EC
50
value ranging from 12.9 to 13.4 μM in mock-infected and SARS-CoV infected cells.
Cell Viability Assay
| Cell Line: | Vero E6 cells (mock-infected or infected with SARS-CoV) |
| Concentration: | 3, 4, 5, 8,10, 15, 20, 30 μM |
| Incubation Time: | 48 hour |
| Result: | Against mock-infected and SARS-CoV infected cells. |