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19992-50-8

中文名稱 ML329
英文名稱 ML329
CAS 19992-50-8
分子式 C16H12N2O4S
分子量 328.34
MOL 文件 19992-50-8.mol
更新日期 2023/03/20 15:41:23
19992-50-8 結(jié)構(gòu)式 19992-50-8 結(jié)構(gòu)式

基本信息

中文別名
化合物ML329
4-((1,4-二氧代-1,4-二氫萘-2-基)氨基)苯磺酰胺
英文別名
ML329
ML329
ML 329
4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide
Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

儲存條件Keep in dark place,Sealed in dry,2-8°C
溶解度DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.1 mg/ml
形態(tài)結(jié)晶固體
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
海關(guān)編碼2935909099

常見問題列表

生物活性
ML329 是一種 micropthalmia-associated transcription factor (MITF) 的抑制劑,可抑制 TRPM-1 promoter 的活性,其IC50值為1.2 μM。
靶點
TargetValue
MITF
()
TRPM-1 promoter
(Cell-free assay)
1.2 μM
體外研究

ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, ML329 will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

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