1919853-46-5
基本信息
5-(N-(4-(N-(2-甲氧基-2-氧代乙基)甲基磺酰氨基)芐基)-1-苯基甲基磺酰氨基)-2-((4-甲基芐基)氧基)苯甲酸甲酯
PTP1B-IN-2
PTP1B inhibitor 2
PTP1B-IN-2
PTP1B INHIBITOR 2
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-100462 | 1919853-46-5 PTP1B-IN-2 | 1919853-46-5 | 1mg | 681元 |
2024/11/08 | HY-100462 | 1919853-46-5 PTP1B-IN-2 | 1919853-46-5 | 5mg | 1200元 |
2024/11/08 | HY-100462 | 1919853-46-5 PTP1B-IN-2 | 1919853-46-5 | 10mg | 1700元 |
常見(jiàn)問(wèn)題列表
Target | Value |
PTP1B
(Cell-free assay) | 50 nM |
PTP1B-IN-2 displays more than 40-fold selectivity for PTP1B over SHP-2 and LAR and 15-fold higher selectivity for PTP1B over the highly homologous TCPTP. PTP1B-IN-2 extends deep into the active site pocket, forming several hydrogen bonds and hydrophobic interactions with key residues of the catalytic site. The binding characteristics between PTP1B domain and ligand shows that PTP1B-IN-2 is an ABC type inhibitor which not only interacted with catalytic site but also B site and C site. PTP1B-IN-2 greatly enhances insulin-mediated IRβ phosphorylation at concentrations of 15 μM and 30 μM. Insulin-stimulated glucose uptake is also significantly increased in L6 myotubes treated with PTP1B-IN-2, and this increase is 16.0%, 19.0% and 38.1% at 5, 10 and 20 μM, respectively .