842148-40-7
中文名稱
AKT 激酶抑制劑
英文名稱
AKT Kinase Inhibitor
CAS
842148-40-7
分子式
C16H19N7O3
分子量
357.37
MOL 文件
842148-40-7.mol
842148-40-7 結(jié)構(gòu)式
基本信息
中文別名
AKT 激酶抑制劑AKT抑制劑(AKT KINASE INHIBITOR)
英文別名
3-[2-(4-amino-15-c]pyridin-4-yl]-
AKT Kinase Inhibitor
AKT Kinase Inhibitor USP/EP/BP
5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4
3-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-propyn-1-ol
2-Propyn-1-ol, 3-[2-(4-aMino-1,2,5-oxadiazol-3-yl)-7-(3-aMinopropoxy)-1-ethyl-1H-iMidazo[4,5-c]pyridin-4-yl]-
AKT Kinase Inhibitor (2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-)
所屬類別
生物化工：Akt 抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)678.8±65.0 °C(Predicted)
密度1.50
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 16.67 mg/mL (46.65 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
酸度系數(shù)(pKa)12.98±0.10(Predicted)
形態(tài)粉末
顏色White to light yellow
常見(jiàn)問(wèn)題列表
生物活性
AKT Kinase Inhibitor 是一種具有抗腫瘤活性的 Akt 抑制劑。靶點(diǎn)
|
Akt
|
體外研究
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion.
體內(nèi)研究
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus.