78824-30-3
中文名稱
山竹子素
英文名稱
garcinol
CAS
78824-30-3
分子式
C38H50O6
分子量
602.8
MOL 文件
78824-30-3.mol
更新日期
2023/03/20 15:41:21
78824-30-3 結(jié)構(gòu)式
基本信息
中文別名
山竹子素 英文別名
garcinolCamboginol
(1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione
(1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione
Bicyclo[3.3.1]non-3-ene-2,9-dione, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (1R,5R,7R)-
(1R,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxy-methylidene]-8,8-dimethyl-1,7-bis(3-methylbut-2-enyl)-5-[(2S)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點132 °C
沸點710.8±60.0 °C(Predicted)
密度1.114±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度可溶于DMSO（高達25mg/ml）或乙醇（高達25mg/ml）。
酸度系數(shù)(pKa)4.50±1.00(Predicted)
形態(tài)黃色固體
顏色黃色
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲存1個月。Garcinol容易氧化。防止暴露在空氣中。
LogP11.546 (est)
山竹子素價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-107569 | 山竹子素 Garcinol | 78824-30-3 | 1mg | 800元 |
| 2024/08/19 | HY-107569 | 山竹子素 Garcinol | 78824-30-3 | 5mg | 2450元 |
| 2024/08/19 | HY-107569 | 山竹子素 Garcinol | 78824-30-3 | 10mM * 1mLin DMSO | 3315元 |
常見問題列表
生物活性
Garcinol 是一種從印度藤黃提取的聚異戊二烯基二苯甲酮，對乙酰膽堿酯酶 (AChE) 和丁酰膽堿酯酶 (BChE) 具有抗膽堿酯酶的特性，IC50 分別為 0.66 μM 和 7.39 μM。Garcinol 還抑制組蛋白乙酰轉(zhuǎn)移酶 (HATs, IC50=7 μM) 和 p300/CPB 相關(guān)因子 (PCAF, IC50=5 μM)。Garcinol 具有抗炎和抗癌活性。靶點
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Human Endogenous Metabolite
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體外研究
Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells.
Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
Cell Proliferation Assay
| Cell Line: | CAL27 and UMSCC1 cells |
| Concentration: | 10, 25, 50 μM |
| Incubation Time: | 24, 48, and 72 hours |
| Result: | Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner. |
Apoptosis Analysis
| Cell Line: | CAL27 and UMSCC1 cells |
| Concentration: | 10, 25, 50 μM |
| Incubation Time: | 24, 48, and 72 hours |
| Result: | Induced apoptosis in HNSCC cells. |
Western Blot Analysis
| Cell Line: | CAL27 cells |
| Concentration: | 50 μM |
| Incubation Time: | 1, 2, 4, 6 hours |
| Result: | Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner. |
體內(nèi)研究
Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth.
| Animal Model: | Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors |
| Dosage: | 1 and 2 mg/kg |
| Administration: | I.p.; five times/week for 4 consecutive weeks |
| Result: | Induced significant inhibition of tumor growth. |