67416-61-9
67416-61-9 結構式
基本信息
3-乙酰-11酮基乳香酸
11-羰基-Β-乙酰乳香酸
乙?；?11酮-Β-乳香酸
11-羰基-B-乙酰乳香酸
11-羰基-Β-乙酰乳香酸
乙?；?11-酮基-Β-乳香酸
11-羰基-Β-乙酰乳香酸標準品
11-羰基-Β-乙酰乳香酸AKBA
3-乙?；?11-酮基-Β-乳香酸
AK-BETABA
AKBA, >98%
Boswellic Acid Impurity 3
BOSWELLIC ACID, ACETYL KETO
Acetyl-11-keto-b-boswellic acid
11-keto-β-boswellic acid acetate
3-Acetyl-11-keto-(-boswellicacid
3-ACETYL-11-KETO-B-BOSWELLIC ACID
3-acetyl-11-keto-β-Boswellic Acid
物理化學性質
常見問題列表
圖：西黃丸藥制劑
0．27% ，最高為1．05% 。建立薄層色譜法和高效液相色譜法可用于西黃丸中 11-羰基-β-乙酰乳香酸的定性定量檢驗，可作為西黃丸現(xiàn)行法定檢驗標準中乳香顯微鑒別的有益補充。
國中藥雜志，2011，36( 10)1330-1332
【2】崔銳,周金云. 乳香化學和藥理的研究進展 [J]. 中國藥學雜志，2003, 38(6): 407-410
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Human Endogenous Metabolite
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AKBA (Acetyl-11-keto-β-boswellic acid) significantly reduced infarct volumes and apoptotic cells, and also increased neurologic scores by elevating the Nrf2 and HO-1 expression in brain tissues in middle cerebral artery occlusion (MCAO) rats at 48 hours post reperfusion. In primary cultured neurons, AKBA increased the Nrf2 and HO-1 expression, which provided protection against OGD-induced oxidative insult. Additionally, AKBA treatment increased Nrf2 binding activity to antioxidant-response elements (ARE).
AKBA (Acetyl-11-keto-β-boswellic acid) significantly inhibited human colon adenocarcinoma growth, showing arrest of the cell cycle in G1-phase and induction of apoptosis.
AKBA (Acetyl-11-keto-β-boswellic acid) triggered significant lipolysis in 3T3-L1 adipocytes as shown by reduced neutral lipids in cytosol and increased free fatty acids in culture medium. Increased lipolysis by AKBA was accompanied by up-regulation of lipolytic enzymes, adipocyte triglyceride lipase (ATGL) and hormone sensitive lipase (HSL), and a decreased expression of lipid droplet stability regulator perilipin. In addition, AKBA (Acetyl-11-keto-β-boswellic acid) treatment reduced phenotypic markers of mature adipocyte aP2, adiponectin and glut-4 in mature adipocytes.
AKBA (Acetyl-11-keto-β-boswellic acid) significantly prevented the formation of intestinal adenomatous polyps without toxicity to mice. AKBA's activity both in the prevention of small intestinal and colonic polyps was more potently than aspirin. Histopathologic examination revealed that AKBA's effect, that is the reduction of polyp size and degree of dysplasia, was more prominent in larger sized polyps, especially those originating in colon.
AKBA (Acetyl-11-keto-β-boswellic acid) administration in mice effectively delayed the growth of HT-29 xenografts without signs of toxicity. The activity of AKBA was more potent than that of aspirin.
AKBA (Acetyl-11-keto-β-boswellic acid) exhibited anti-cancer activity in vitro and in vivo. With oral application in mice, AKBA significantly inhibited SGC-7901 and MKN-45 xenografts without toxicity.