| Identification | Back Directory | [Name]
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID | [CAS]
67416-61-9 | [Synonyms]
AKBA
AK-BETABA
AKBA, >98%
Boswellic Acid Impurity 3
BOSWELLIC ACID, ACETYL KETO
Acetyl-11-keto-b-boswellic acid
11-keto-β-boswellic acid acetate
3-Acetyl-11-keto-(-boswellicacid
3-ACETYL-11-KETO-B-BOSWELLIC ACID
3-acetyl-11-keto-β-Boswellic Acid
ACETYL-11-KETO-B-BOSWELLIC ACID, 3
ACETYL-11-KETO-BETA-BOSWELLIC ACID
3-O-acetyl-11-keto-β-boswellic acid
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID
Acetyl-11-keto--boswellic acid (AKBA)
3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID
3α-Acetoxy-11-oxo-12-ursen-24-oic acid
Beta-boswellic acid,3-acetyl,11-keto、AKBA
3-Acetyl-11-Keto-Beta-Boswellic Acid (20 mg)
3-ACETYL-11-KETONE-BETA-ACETYLBOSWELLIC ACID
3-ACETYL-11-KETO-BETA-BOSWELLIC ACID USP/EP/BP
Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata
3-O-Acetyl-11-keto--boswellicacid,Boswelliaserrata
Urs-12-en-23-oic acid, 3-(acetyloxy)-11-oxo-, (3a,4b)-
Urs-12-en-23-oic acid, 3-(acetyloxy)-11-oxo-, (3α,4β)-
3-O-Acetyl-11-keto-β-boswellic acid from Boswellia serrata
3-O-ACETYL-11-KETO-BOSWELLIC ACID, BOSWELLIA SERRATA, >99%
3-Acetyl-11-keto-β-boswellic acid, 98%, from Boswellia carterii Birdw | [Molecular Formula]
C32H48O5 | [MDL Number]
MFCD03788777 | [MOL File]
67416-61-9.mol | [Molecular Weight]
512.72 |
| Chemical Properties | Back Directory | [Melting point ]
271℃ | [Boiling point ]
600.3±55.0 °C(Predicted) | [density ]
1.13±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
neat | [pka]
4.28±0.70(Predicted) | [color ]
White to Off-White | [LogP]
7.418 (est) |
| Hazard Information | Back Directory | [Description]
3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense).1 It selectively inhibits 5-lipoxygenase (IC50 = 1.5 μM) in an enzyme-directed, nonredox, and noncompetitive manner.2 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.3,4,5,6 | [Uses]
Shows antitumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topoisomerase I and IIa inhibitor leading to apoptosis. 10-times more potent than 3-O-acetyl-β-boswellic acid . Exhibits in vivo efficacy in tumor growth and inhibition. | [Definition]
ChEBI: 3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid. | [in vitro]
akba exerted a time- and concentration -dependent cytotoxicity on androgen-independent prostate cancer cells. akba blocked proliferation and elicited apoptosis in the chemoresistant and androgen-independent human pc-3 prostate cancer cells by the release of mitochondrial cytochrome c and dna fragmentation. also, akba concentration-dependently inhibited nf-κb signaling, yet it did not directly affect the nf-κb binding to dna. additionally, akba suppressed inhibitor κb kinase and nf-κb-dependent antiapoptotic gene products in pc-3 cells [1]. | [in vivo]
pc-3 xenotransplanted male nmri/nu-nu mice were injected intraperitoneally at 100 μmol/kg daily for three weeks. akba dampened growth and proliferation of pc-3 xenografts in nude mice and elicited apoptosis. moreover, compared with the control group, akba reduced the tumor volume and the invasiveness of the tumor into the surrounding tissues [1]. | [IC 50]
1.5 μm | [References]
[1]. syrovets, t., gschwend, j., buchele, b., laumonnier, y., zugmaier, w., genze, f., & simmet, t. inhibition of iκb kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent pc-3 prostate cancer cells in vitro and in vivo. journal of biological chemistry. 2004; 280(7): 6170-6180. |
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