28282-25-9
中文名稱
BETA-嵐香酮酸
英文名稱
β-Elemonic Acid
CAS
28282-25-9
分子式
C30H46O3
分子量
454.68
MOL 文件
28282-25-9.mol
更新日期
2024/12/20 18:42:31
28282-25-9 結(jié)構(gòu)式
基本信息
中文別名
Β欖香酮酸Β-欖香酮酸
Β-欖香酮酸
Β-嵐香酮酸
Β-欖香酮酸對(duì)照品
Β-欖香酮酸標(biāo)準(zhǔn)品
BETA-嵐香酮酸
Β-嵐香酮酸, 來(lái)源于橄欖
Β-ELEMONIC ACID
BETA-嵐香酮酸、BETA-欖香酮酸
英文別名
β-ElemonicBeta-EleMonic
β-deMonic acid
β-demonic-acid
B-ELEMONIC ACID
β-Elemonic acid
β-Elemonic acid
Elemadienonic acid
BETA-ELEMONIC ACID
3-Oxotirucallic acid
所屬類別
分析化學(xué)：離子色譜試劑物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于乳香。
熔點(diǎn)224-225°C
沸點(diǎn)565.2±50.0 °C(Predicted)
密度1.07
儲(chǔ)存條件2-8°C
溶解度DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml
酸度系數(shù)(pKa)4.65±0.10(Predicted)
形態(tài)A crystalline solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
β-Elemonic acid 是從乳香樹(shù)中分離得到的三萜。β-Elemonic acid 誘導(dǎo)細(xì)胞凋亡，活性氧 (ROS) 和 COX-2 表達(dá)，并抑制脯氨酰內(nèi)肽酶。β-Elemonic acid 具有抗癌和抗炎作用。靶點(diǎn)
|
COX-2
|
體外研究
β-elemonic acid (1, 3, 10, 20 μM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner.
β-elemonic acid (1, 3, 10, 20 μM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC
50
value following a 24-h exposure to β-elemonic acid was 6.92 μM.
β-elemonic acid (20 μM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase.
β-elemonic acid (1, 3, 10, 20 μM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.