56-34-8
56-34-8 結(jié)構(gòu)式
基本信息
N,N,N-三乙基乙銨氯化物
四乙基氯化銨水合物
氯化四乙胺
四乙基氯化銨(TEAC)
氯化四乙銨
氯化四乙基銨
四乙銨化氯
四乙胺氯化物
四乙基氯化胺
TEA
TEA CHLORIDE
TETRAETHYLAMMONIUM CHLORIDE
Ethanaminium,N,N,N-triethyl-,chloride
n,n,n-triethyl-ethanaminiuchloride
n,n,n-triethylethanaminiumchloride
teac
tetraethyl-ammoniuchloride
Tetraethylammonium choride
TETRAETHYLAMMONIUM CHLORIDE SOLUTION
TETRAETHYLAMMONIUM CHLORIDE, FOR MOLECUL AR BIOLOGY
TETRAETHYLAMMONIUM CHLORIDE, ELECTRO-CHE MICAL GRADE
TETRAETHYLAMMONIUM CHLORIDE NICOTINIC BL OCKING AG
Tetraethylammonium
TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL,REAGENT
AMMONIUM,TETRAETHYL-,CHLORIDE
TETRAETHYLAMINEHYDROCHLORIDE
Tetraethylammonium chloride monohydrate, 99+%
Tetraethylammonium chloride ,98%
物理化學(xué)性質(zhì)
λ: 280 nm Amax: 0.03
安全數(shù)據(jù)
應(yīng)用領(lǐng)域
常見問題列表
(1) 將45g氯乙烷溶于300g二甲苯中，待用； (2) 將10g三乙胺、50g乙醚、150g二甲苯加入高壓反應(yīng)爸中，于70°C下，向高壓反應(yīng)爸 中滴加250g氯乙烷-二甲苯溶液，滴加完畢后，保溫反應(yīng)半小時后，通入氣體保持高壓釜內(nèi) 壓力為3MPa，于120°C下反應(yīng)12小時后，停止通氣，緩慢打開放氣閥，降溫至室溫； (3) 將步驟⑵所得反應(yīng)液過濾，得58.3g濾餅A為四乙基氯化銨粗品，將四乙基氯化銨 粗品加入100g水中，于45°C下攪拌至大部分粗品溶解，趁熱過濾，得20.2g濾液加入80g乙 腈、120g戊二醇混合溶劑中，攪拌靜置半小時后，過濾，濾餅B烘干即得15.9g四乙基氯化銨， 純度為99.7%，收率為95.5%。
四乙基氯化銨是一種非選擇性的鉀通道 (potassium channel) 阻滯劑，它是有機(jī)陽離子轉(zhuǎn)運(yùn)蛋白的良好底物，并具有抗腫瘤特性。
Tetraethylammonium (0.2-60 mM; 24-72 hours; C6 and 9L glioma cells) treatment inhibits the proliferation of C6 and 9L cells in a dose- and time-dependent manner.
Tetraethylammonium (40 mM; 24-72 hours; C6 and 9L glioma cells) treatment significantly increases apoptosis in cells.
Tetraethylammonium (40 mM; 12-48 hours; C6 and 9L glioma cells) treatment significantly elevates Bax/Bcl-2 protein ratio in a time-dependent manner.
The generation of intracellular ROS increased in C6 and 9L cells by the addition of 20 and 40 mM Tetraethylammonium.
Cell Proliferation Assay
| Cell Line: | Rat C6 and 9L glioma cells |
| Concentration: | 0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM |
| Incubation Time: | 24 hours, 48 hours and 72 hours |
| Result: | Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner. |
Apoptosis Analysis
| Cell Line: | Rat C6 and 9L glioma cells |
| Concentration: | 40 mM |
| Incubation Time: | 24 hours, 48 hours and 72 hours |
| Result: | Significantly increased apoptosis in cells. |
Western Blot Analysis
| Cell Line: | Rat C6 and 9L glioma cells |
| Concentration: | 40 mM |
| Incubation Time: | 12 hours, 24 hours, 48 hours |
| Result: | The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h. |
四乙基氯化銨（1 mM、3 mM 和 5 mM）顯著增加大鼠結(jié)腸和直腸在縱向和環(huán)形方向上的收縮幅度和頻率。 5 mM 和 15 mM 的四乙基氯化銨對從肛門向結(jié)腸腔內(nèi)局部施用四乙基銨的大鼠的結(jié)腸和直腸組織學(xué)沒有影響 10 天。