548-83-4
基本信息
高良姜素
高良姜精
3,5,7-三羥基-2-苯基-4H-1-苯并呋喃-4-酮
3,5.7-三羥基黃酮
3,5,7-TRIHYDROXYFLAVONE
GALANGIN
NORIZALPININ
3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on
3,5,7-trihydroxy-flavon
3,5,7-trihydroxy-2-phenyl-4-benzopyrone
3,5,7-Trihydroxyflavone (Galangin)
3,5,7-Trihydroxyflavone,97%
GALANGIN hplc
GALANGIN WITH HPLC
2-Phenyl-3,5,7-trihydroxy-4H-1-benzopyran-4-one
3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Galengin
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
Galangin (Norizalpinin)?inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner.?Galangin?also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth.?Galangin?causes a potent, dose-dependent inhibition of?CYP1A1?activity, as measured by ethoxyresorufin-O-deethylase?activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that?galangin?inhibits CYP1A1?activity?in a noncompetitive manner.?Galangin?causes an increase in the level of?CYP1A1?mRNA, indicating that it may be an?agonist?of the?aryl?hydrocarbon?receptor, but it inhibits the induction of?CYP1A1?mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD).?Galangin?also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the?CYP1A1?promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/11 | XW05488342 | 高良姜素 3,5,7-trihydroxy flavone;3,5,7-trihydroxy-2-phenyl-4-benzopyrone;3,5,7-trihydroxy-2-phenyl-4h-1-benzopyran-4-one;galangin;norizalpinin | 548-83-4 | 100MG | 555元 |
2024/11/08 | L14223 | 3,5,7-三羥基黃酮, 97% 3,5,7-Trihydroxyflavone, 97% | 548-83-4 | 25mg | 1159元 |
2024/11/08 | L14223 | 3,5,7-三羥基黃酮, 97% 3,5,7-Trihydroxyflavone, 97% | 548-83-4 | 100mg | 3224元 |