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548-83-4

中文名稱 高良姜素
英文名稱 Galangin
CAS 548-83-4
EINECS 編號 208-960-4
分子式 C15H10O5
MDL 編號 MFCD00006833
分子量 270.24
MOL 文件 548-83-4.mol
更新日期 2024/12/23 10:25:13
548-83-4 結(jié)構(gòu)式 548-83-4 結(jié)構(gòu)式

基本信息

中文別名
3,5,7-三羥基黃酮
高良姜素
高良姜精
3,5,7-三羥基-2-苯基-4H-1-苯并呋喃-4-酮
3,5.7-三羥基黃酮
英文別名
3,5,7-trihydroxy-2-phenyl-chromen-4-one
3,5,7-TRIHYDROXYFLAVONE
GALANGIN
NORIZALPININ
3,5,7-trihydroxy-2-phenyl-4h-benzopyran-4-on
3,5,7-trihydroxy-flavon
3,5,7-trihydroxy-2-phenyl-4-benzopyrone
3,5,7-Trihydroxyflavone (Galangin)
3,5,7-Trihydroxyflavone,97%
GALANGIN hplc
GALANGIN WITH HPLC
2-Phenyl-3,5,7-trihydroxy-4H-1-benzopyran-4-one
3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Galengin
所屬類別
天然產(chǎn)物:黃酮類化合物

物理化學(xué)性質(zhì)

外觀性質(zhì)微黃色針狀結(jié)晶(乙醇), 尚易溶于乙醇及乙醚。在堿的水溶液中成黃色溶液??缮A。熔點:214-215℃
外觀性狀淡黃色結(jié)晶粉末,易溶于乙醇、乙醚,來源于姜科植物高良姜(Alpinia officinarum Hance)根。
熔點214-215 °C(lit.)
沸點333.35°C (rough estimate)
密度1.2319 (rough estimate)
折射率1.6000 (estimate)
儲存條件room temp
溶解度可溶于丙酮(少許)、乙酸乙酯(少許)
酸度系數(shù)(pKa)6.32±0.40(Predicted)
形態(tài)固體
顏色淡黃色至黃色
Merck14,4339
BRN272179
InChIKeyVCCRNZQBSJXYJD-UHFFFAOYSA-N
LogP3.322 (est)
CAS 數(shù)據(jù)庫548-83-4(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
防范說明P301+P312+P330
危險品標(biāo)志Xi
危險類別碼R36/37/38
安全說明S26-S37/39
WGK Germany3
RTECS號LK9275500
海關(guān)編碼29329990

應(yīng)用領(lǐng)域

用途一
能使鼠傷寒沙門氏菌ta98和ta100發(fā)生誘變。

常見問題列表

用途
高良姜是一種在高良姜、高良姜和蜂膠中發(fā)現(xiàn)的黃烷類物質(zhì)。高良姜已被證明可以抑制雌激素受體陽性的MCF-7人乳腺癌細(xì)胞的增殖,并延緩乳腺腫瘤的發(fā)生。
生物活性
Galangin (Norizalpinin) 是 arylhydrocarbon 受體的調(diào)節(jié)劑,同時抑制 CYP1A1 的活性。
體外研究

Galangin (Norizalpinin)?inhibits the catabolic breakdown of DMBA, as measured by thin-layer chromatography, in a dose-dependent manner.?Galangin?also inhibits the formation of DMBA-DNA adducts, and prevents DMBA-induced inhibition of cell growth.?Galangin?causes a potent, dose-dependent inhibition of?CYP1A1?activity, as measured by ethoxyresorufin-O-deethylase?activity, in intact cells and in microsomes isolated from DMBA-treated cells. Analysis of the inhibition kinetics by double-reciprocal plot demonstrates that?galangin?inhibits CYP1A1?activity?in a noncompetitive manner.?Galangin?causes an increase in the level of?CYP1A1?mRNA, indicating that it may be an?agonist?of the?aryl?hydrocarbon?receptor, but it inhibits the induction of?CYP1A1?mRNA by DMBA or by 2,3,5,7-tetrachlorodibenzo-p-dioxin (TCDD).?Galangin?also inhibits the DMBA- or TCDD-induced transcription of a reporter vector containing the?CYP1A1?promoter. Galangin treatment inhibits cell proliferation and induced autophagy (130 μM) and apoptosis (370 μM). In particular, galangin treatment in HepG2 cells causes (1) an accumulation of autophagosomes, (2) elevated levels of microtubule-associated protein light chain 3, and (3) an increased percentage of cells with vacuoles. p53 expression is also increased. The galangin-induced autophagy is attenuated by the inhibition of p53 in HepG2 cells, and overexpression of p53 in Hep3B cells restored the galangin-induced higher percentage of cells with vacuoles to normal level.

高良姜素價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/11XW05488342高良姜素
3,5,7-trihydroxy flavone;3,5,7-trihydroxy-2-phenyl-4-benzopyrone;3,5,7-trihydroxy-2-phenyl-4h-1-benzopyran-4-one;galangin;norizalpinin
548-83-4100MG555元
2024/11/08L142233,5,7-三羥基黃酮, 97%
3,5,7-Trihydroxyflavone, 97%
548-83-425mg1159元
2024/11/08L142233,5,7-三羥基黃酮, 97%
3,5,7-Trihydroxyflavone, 97%
548-83-4100mg3224元
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