| Identification | Back Directory | [Name]
BETA-ELEMONIC ACID | [CAS]
28282-25-9 | [Synonyms]
β-Elemonic
Beta-EleMonic
β-deMonic acid
β-demonic-acid
β-Elemonic acid
B-ELEMONIC ACID
β-Elemonic acid
BETA-ELEMONIC ACID
Elemadienonic acid
3-Oxotirucallic acid
3-Oxotirucallenoic acid
3-Oxo-8,24-tirucalledien-21-oic acid
3-OXOTIRUCALLA-8,24-DIEN-21-OIC ACID
3-Ketotirucalla-8,24-dien-21-oic acid
(20S)-3-Oxoeupha-8,24-diene-21-oic acid
3-Oxo-5α-tirucalla-8,24-dien-21-oic acid
(13α,14β,17α,20S)-3-Oxolanosta-8,24-dien-21-oic acid
(13α,14β,17α,20S)-3-Oxo-5α-lanosta-8,24-dien-21-oic acid
Lanosta-8,24-dien-21-oic acid, 3-oxo-, (13α,14β,17α,20S)-
β-Elemonic acid, 98%, from Canarium album (Lour.) Raeusch.
(13alpha,14beta,17alpha,20S)-3-Oxolanosta-8,24-dien-21-oic acid | [EINECS(EC#)]
300-005-5 | [Molecular Formula]
C30H46O3 | [MDL Number]
MFCD00467083 | [MOL File]
28282-25-9.mol | [Molecular Weight]
454.68 |
| Chemical Properties | Back Directory | [Melting point ]
224-225°C | [Boiling point ]
565.2±50.0 °C(Predicted) | [density ]
1.07 | [storage temp. ]
2-8°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
4.65±0.10(Predicted) | [color ]
White to off-white |
| Questions And Answer | Back Directory | [Description]
β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 μM) in vitro. β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 μM) in vitro. | [Uses]
beta-Elemonic acid is found in herbs and spices. beta-Elemonic acid is a constituent of elemi resin. beta-Elemonic acid is a flavouring agent. |
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